Circuit minimizes current drain caused by neon indicator lamps

Circuit lights neon lamp by back leakage current of the driving transistor, rather than by the transistors saturation or ''on-state'' current, thereby eliminating lowering of the voltage necessary for indication. Circuit has operating speed greater than indication circuit using a saturation principle and aids in power rationing

"Go, tell them: thoughts towards a theology of preaching" by Robert Hendrie

Review of Robert Hendrie, Go, tell them: thoughts towards a theology of preaching (London: St Paul’s Publishing, 2006)Publisher PD

Optical enhancement of sensitivity in laser Doppler velocity systems

Utilization of optical enhancement techniques prevents loss of light by reflections at the photocathode of a photomultiplier and increases signal detection sensitivity

Solid state microwave source development program Final report

Microstrip oscillator for solid state microwave sourc

The Local Effects of Cosmological Variations in Physical 'Constants' and Scalar Fields I. Spherically Symmetric Spacetimes

We apply the method of matched asymptotic expansions to analyse whether cosmological variations in physical `constants' and scalar fields are detectable, locally, on the surface of local gravitationally bound systems such as planets and stars, or inside virialised systems like galaxies and clusters. We assume spherical symmetry and derive a sufficient condition for the local time variation of the scalar fields that drive varying constants to track the cosmological one. We calculate a number of specific examples in detail by matching the Schwarzschild spacetime to spherically symmetric inhomogeneous Tolman-Bondi metrics in an intermediate region by rigorously construction matched asymptotic expansions on cosmological and local astronomical scales which overlap in an intermediate domain. We conclude that, independent of the details of the scalar-field theory describing the varying `constant', the condition for cosmological variations to be measured locally is almost always satisfied in physically realistic situations. The proof of this statement provides a rigorous justification for using terrestrial experiments and solar system observations to constrain or detect any cosmological time variations in the traditional `constants' of Nature.Comment: 30 pages, 3 figures; corrected typo

Indications for liver transplantation in the cyclosporine era

One hundred seventy orthotopic liver transplants were performed under conventional immunosuppression with azathioprine and steroids with 1- and 5-year survivals of 32.9% and 20.0%, respectively. Since the introduction of cyclosporine-prednisone therapy in March 1980, 313 primary orthotopic liver transplants have been performed. Actuarial survivals at 1 and 5 years have improved to 69.7% and 62.8%, respectively. Biliary atresia is now the most common indication for liver replacement. In adults, primary biliary cirrhosis and sclerosing cholangitis have become more common indications for transplantation, and alcoholic cirrhosis and primary liver malignancy as indications have declined. Early enthusiasm for liver transplantation in patients with hepatic cancer has been tempered by the finding that recurrence is both common and rapid. An increasing number of patients with inborn errors of metabolism originating in the liver are receiving transplants, including patients with Wilson's disease, tyrosinemia, alpha-1-antitrypsin deficiency, glycogen storage disease, familial hypercholesterolemia, and hemochromatosis. Survival in this group of patients has been excellent (74.4% at 1 and 5 years). A hemophiliac who received a transplant for postnecrotic cirrhosis has survived and may have been cured of his hemophilia. About 20% of patients require retransplantation for rejection, technical failure, or primary graft failure. Only 4 of the patients receiving retransplants under conventional immunosuppression survived beyond 6 months, and all died within 14 months of retransplantation. Sixty-eight patients have received retransplants under cyclosporine-prednisone. Thirty-one patients are surviving, all for at least 1 year. Six of the 12 patients requiring a third transplant are alive 2 to 3 years after the primary operation. An aggressive approach to retransplantation in the patient with a failed graft is justified

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells.

CD8+ T cells responding to infection differentiate into a heterogeneous population composed of progeny that are short-lived and participate in the immediate, acute response and those that provide long-lasting host protection. Although it is appreciated that distinct functional and phenotypic CD8+ T cell subsets persist, it is unclear whether there is plasticity among subsets and what mechanisms maintain subset-specific differences. Here, we show that continued Id2 regulation of E-protein activity is required to maintain the KLRG1hi CD8+ T cell population after lymphocytic choriomeningitis virus infection. Induced deletion of Id2 phenotypically and transcriptionally transformed the KLRG1hi "terminal" effector/effector-memory CD8+ T cell population into a KLRG1lo memory-like population, promoting a gene-expression program that resembled that of central memory T cells. Our results question the idea that KLRG1hi CD8+ T cells are necessarily terminally programmed and suggest that sustained regulation is required to maintain distinct CD8+ T cell states

A low-luminosity soft state in the short period black hole X-ray binary Swift J1753.5-0127

We present results from the spectral fitting of the candidate black hole X-ray binary Swift J1753.5-0127 in an accretion state previously unseen in this source. We fit the 0.7-78 keV spectrum with a number of models, however the preferred model is one of a multi-temperature disk with an inner disk temperature $\mathrm{k}T_\mathrm{in}=0.252\pm0.003$ keV scattered into a steep power-law with photon index $\Gamma=6.39^{+0.08}_{-0.02}$ and an additional hard power law tail ($\Gamma=1.79\pm0.02$). We report on the emergence of a strong disk-dominated component in the X-ray spectrum and we conclude that the source has entered the soft state for the first time in its ~10 year prolonged outburst. Using reasonable estimates for the distance to the source ($3$ kpc) and black hole mass ($5M_{\odot}$), we find the unabsorbed luminosity (0.1-100 keV) to be $\approx0.60$% of the Eddington luminosity, making this one of the lowest luminosity soft states recorded in X-ray binaries. We also find that the accretion disk extended towards the compact object during its transition from hard to soft, with the inner radius estimated to be $R_{\mathrm{in}}=28.0^{+0.7}_{-0.4} R_g$ or ~$12R_g$, dependent on the boundary condition chosen, assuming the above distance and mass, a spectral hardening factor $f=1.7$ and a binary inclination $i=55^{\circ}$.Comment: 10 pages, 5 figures, accepted for publication in MNRA