Nuclear gas dynamics in Arp 220 - sub-kiloparsec scale atomic hydrogen disks

We present new, high angular resolution (~0.22") MERLIN observations of neutral hydrogen (HI) absorption and 21-cm radio continuum emission across the central ~900 parsecs of the ultraluminous infrared galaxy, Arp220. Spatially resolved HI absorption is detected against the morphologically complex and extended 21-cm radio continuum emission, consistent with two counterrotating disks of neutral hydrogen, with a small bridge of gas connecting the two. We propose a merger model in which the two nuclei represent the galaxy cores which have survived the initial encounter and are now in the final stages of merging, similar to conclusions drawn from previous CO studies (Sakamoto, Scoville & Yun 1999). However, we suggest that instead of being coplanar with the main CO disk (in which the eastern nucleus is embedded), the western nucleus lies above it and, as suggested by bridge of HI connecting the two nuclei, will soon complete its final merger with the main disk. We suggest that the collection of radio supernovae (RSN) detected in VLBA studies in the more compact western nucleus represent the second burst of star formation associated with this final merger stage and that free-free absorption due to ionised gas in the bulge-like component can account for the observed RSN distribution. (Abridged)Comment: 26 pages including 8 figures and 1 table; accepted for publication in Ap

Optical Imaging of Very Luminous Infrared Galaxy Systems: Photometric Properties and Late Evolution

A sample of 19 low redshift (0.03$<$z$<$0.07) very luminous infrared galaxy (VLIRG: $10^{11}L_\odot<$ L[8-1000 $\mu$m] $< 10^{12} L_\odot$) systems (30 galaxies) has been imaged in $B$, $V$, and $I$. These objects cover a luminosity range that is key to linking the most luminous infrared galaxies with the population of galaxies at large. We have obtained photometry for all of these VLIRG systems, the individual galaxies (when detached), and their nuclei, and the relative behavior of these classes has been studied in optical color-magnitude diagrams. The photometric properties of the sample are also compared with previously studied samples of ULIRGs. The mean observed photometric properties of VLIRG and ULIRG samples, considered as a whole, are indistinguishable at optical wavelengths. This suggests that not only ULIRG, but also the more numerous population of VLIRGs, have similar rest-frame optical photometric properties as the submillimeter galaxies (SMG), reinforcing the connection between low-{\it z} LIRGs -- high-{\it z} SMGs. When the nuclei of the {\it young} and {\it old} interacting systems are considered separately, some differences between the VLIRG and the ULIRG samples are found. In particular, the old VLIRGs are less luminous and redder than old ULIRG systems. If confirmed with larger samples, this behavior suggests that the late-stage evolution is different for VLIRGs and ULIRGs. Specifically, as suggested from spectroscopic data, the present photometric observations support the idea that the activity during the late phases of VLIRG evolution is dominated by starbursts, while a higher proportion of ULIRGs could evolve into a QSO type of object.Comment: 27 pages, 5 figures (degraded to reduce space). Figures 1 and 2 are multiple page figures (i.e. Fig 1a,b and Fig2a-g

Topology of the Galaxy Distribution in the Hubble Deep Fields

We have studied topology of the distribution of the high redshift galaxies identified in the Hubble Deep Field (HDF) North and South. The two-dimensional genus is measured from the projected distributions of the HDF galaxies at angular scales from $3.8''$ to $6.1''$. We have also divided the samples into three redshift slices with roughly equal number of galaxies using photometric redshifts to see possible evolutionary effects on the topology. The genus curve of the HDF North clearly indicates clustering of galaxies over the Poisson distribution while the clustering is somewhat weaker in the HDF South. This clustering is mainly due to the nearer galaxies in the samples. We have also found that the genus curve of galaxies in the HDF is consistent with the Gaussian random phase distribution with no significant redshift dependence.Comment: 14 pages, 4 figures, submitted to Ap

Modeling the growth of multicellular cancer spheroids in a\ud bioengineered 3D microenvironment and their treatment with an\ud anti-cancer drug

A critical step in the dissemination of ovarian cancer cells is the formation of multicellular spheroids from cells shed from the primary tumor. The objectives of this study were to establish and validate bioengineered three-dimensional (3D) microenvironments for culturing ovarian cancer cells in vitro and simultaneously to develop computational models describing the growth of multicellular spheroids in these bioengineered matrices. Cancer cells derived from human epithelial ovarian carcinoma were embedded within biomimetic hydrogels of varying stiffness and cultured for up to 4 weeks. Immunohistochemistry was used to quantify the dependence of cell proliferation and apoptosis on matrix stiffness, long-term culture and treatment with the anti-cancer drug paclitaxel.\ud \ud Two computational models were developed. In the first model, each spheroid was treated as an incompressible porous medium, whereas in the second model the concept of morphoelasticity was used to incorporate details about internal stresses and strains. Each model was formulated as a free boundary problem. Functional forms for cell proliferation and apoptosis motivated by the experimental work were applied and the predictions of both models compared with the output from the experiments. Both models simulated how the growth of cancer spheroids was influenced by mechanical and biochemical stimuli including matrix stiffness, culture time and treatment with paclitaxel. Our mathematical models provide new perspectives on previous experimental results and have informed the design of new 3D studies of multicellular cancer spheroids

Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach

We have integrated a bioengineered three-dimensional platform by generating multicellular cancer spheroids in a controlled microenvironment with a mathematical model to investigate\ud confined tumour growth and to model its impact on cellular processes