Nuclear Physics Neutrino PreTown Meeting: Summary and Recommendations

In preparation for the nuclear physics Long Range Plan exercise, a group of 104 neutrino physicists met in Seattle September 21-23 to discuss both the present state of the field and the new opportunities of the next decade. This report summarizes the conclusions of that meeting and presents its recommendations. Further information is available at the workshop's web site. This report will be further reviewed at the upcoming Oakland Town Meeting.Comment: Latex, 31 pages. This version has been updated to include final Comments from the working group

The uncertainties on the EFT coupling limits for direct dark matter detection experiments stemming from uncertainties of target properties

Direct detection experiments are still one of the most promising ways to unravel the nature of dark matter. To fully understand how well these experiments constrain the dark matter interactions with the Standard Model particles, all the uncertainties affecting the calculations must be known. It is especially critical now because direct detection experiments recently moved from placing limits only on the two elementary spin independent and spin dependent operators to the complete set of possible operators coupling dark matter and nuclei in non-relativistic theory. In our work, we estimate the effect of nuclear configuration-interaction uncertainties on the exclusion bounds for one of the existing xenon-based experiments for all fifteen operators. We find that for operator number 13 the $\pm1\sigma$ uncertainty on the coupling between the dark matter and nucleon can reach more than 50% for dark matter masses between 10 and 1000 GeV. In addition, we discuss how quantum computers can help to reduce this uncertainty.Comment: 12 pages, 6 figures; submitted to Phys. Rev. D, May 17, 202

Soluble fms-Like Tyrosine Kinase 1 (sFlt1), Endoglin and Placental Growth Factor (PlGF) in Preeclampsia among High Risk Pregnancies

Background: Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women. The objective of this study was to investigate whether similar changes can be detected in pregnant women at high-risk to develop the syndrome.Methods: This study is a secondary analysis of the NICHD MFMU trial of aspirin to prevent preeclampsia in high-risk pregnancies. Serum samples were available from 194 women with pre-existing diabetes, 313 with chronic hypertension, 234 with multifetal gestation, and 252 with a history of preeclampsia in a previous pregnancy. Samples collected across pregnancy were analyzed in a blinded fashion for sFlt1, sEng and PlGF.Results: The odds of developing preeclampsia were significantly increased among women with multiple fetuses for each 2-fold elevation in sFlt1, sEng and the ratio of angiogenic factors (e.g. OR 2.18, 95% CI 1.46-3.32), and significantly decreased for each 2-fold elevation in circulating PlGF (OR 0.50, 95% CI 0.30-0.82) between 7 and 26 weeks' gestation. Cross-sectional analysis of the angiogenic factors across gestation showed significant differences during the third trimester in women who develop preeclampsia compared with appropriate controls in all high-risk groups. However, when data were examined in relation to the gestational week when preeclampsia was diagnosed only sFlt1 was significantly higher 2 to 5 weeks before the clinical onset of preeclampsia and only in women with previous preeclampsia.Conclusions: The pattern of elevated concentrations of sFlt1 and sEng, and low PlGF in high-risk pregnant subjects who develop preeclampsia is similar to that reported in low-risk pregnant women. However, differences in these factors among high-risk women who do and do not develop preeclampsia are modest, and do not appear to be clinically useful predictors in these high-risk pregnant women.</p

Radially dependent stray field signature of chiral magnetic skyrmions

Magnetic skyrmions are topological spin structures that arise in chiral magnetic systems which exhibit broken inversion symmetry and high spin-orbit coupling resulting in a sizable Dzyaloshinskii-Moriya interaction. Understanding the local spin texture of skyrmions is a vital metrological step in the development of skyrmionic technologies required for novel logic or storage devices in addition to providing fundamental insight into the nanoscale chiral interactions inherent to these systems. Here, we propose that there exists a radially dependent stray field signature that emanates from magnetic skyrmions. We employ quantitative magnetic force microscopy to experimentally explore this stray field signature. To corroborate the experimental observations a semianalytical model is developed which is validated against micromagnetic simulations. This unique approach provides a route to understand the unique radially dependent field signature from skyrmions, which allows an understanding of the underlying local magnetization profile to be obtained. From a practical standpoint, our results provide a rapid approach to validate outputs from numerical or micromagnetic simulations. This approach could be employed to optimize the complex matrix of magnetic parameters required for fabricating and modeling skyrmionic systems, in turn accelerating the technology readiness level of skyrmionic based devices

Editorial of Special Issue of National Identities: Alevism as an ethno-religious identity: Contested boundaries

No abstract for editorial but this is the opening paragraph: This special issue on Alevism and trans/national Alevi identity critically engages with the relationship between religion, ethnicity and national identity. The core issues are as follows: • how ethnicity and religion are conceptualised for a relatively invisible ethnic group in different national contexts; • how religion and ethnicity intersect when Alevism is both a faith and an ethnic identity, especially when conceptions of that identity are contested; • how identity is shaped through state policies within different national policy contexts and how etic definitions of minority communities are constructed by the state or other agencies with the power to impose them on the community in contrast to the emic or self-definitions of Aleviness from within the Alevi community; • how despite the fragmented, heterogeneous nature of Alevi communities, there is also a sense of a single, transnational imaginary community, at least for the purposes of political assimilation/integration and activism; • how education and other arenas of political, religious and cultural engagement at local, national and transnational levels create the possibilities, both positively and negatively, for future action/policy to situate minority ethnic communities

Mucocèle Frontale avec extension orbito -palpébrale - Cas historique -

Introduction : La mucocèle est une tumeur kystique bénigne et rare. Elle se développe aux dépens des muqueuses sinusiennes et envahit l’orbite par destruction osseuse. son traitement chirurgical consiste en une exérèse du kyste et un drainage du sinus causal.Matériels et méthodes :Nous rapportons l’observation d’un patient âgé de 62 ans, ayant comme antécédent un traumatisme oculaire contusif droit y’a 2 ans, qui présente depuis 18 mois une tuméfaction palpébrale supérieure droite cachant et refoulant le globe oculaire en bas et en dehors.Résultats :L’examen ophtalmologique objective une tuméfaction palpébrale droite cachant et refoulant le globe oculaire en bas et en dehors avec exophtalmie non axile indolore non pulsatile, une motilité oculaire réduite dans les 9 positions du regard, une acuité visuelle chiffrée à 1/10ème, l’examen du segment antérieur trouve une kératite ponctuée superficielle, l’examen du fond de l’oeil est impossible à réaliser. La TDM orbito cérébrale objective une masse tissulaire du toit de l’orbite avec lyse osseuse par endroits probablement en rapport avec une mucocèle du sinus frontal droit. Le patient a été opéré par voie externe (voie sourcilière de Jacques) par une exérèse de la membrane mucocélique sans drainage du sinus. Le diagnostic est confirmé par un examen histologique.Discussion : La mucocèle frontale est une tumeur bénigne lentement évolutive. Elle peut s’étendre en absence du traitement soit vers l’endocrâne soit vers la région oculo-orbitaire en arrière du septum responsable d’une extension intra-orbitaire, ou en avant du septum orbitaire donnant la forme palpébrale supérieure prépondérante comme pour ce patient. Le traitement consiste à une exérèse chirurgicale du kyste avec drainage du sinus causal, qui n’a pas été réalisé pour ce patient compte tenu de la destruction de la paroi antérieure et d’un amincissement très important de la paroi postérieure du sinus frontal avec dure-mère mise à nu, par crainte du risque infectieux.Conclusion : La mucocèle est une tumeur rare, qui touche surtout l’adulte. Le diagnostic tardif explique l’étendue des lésions vers l’endocrâne ou l’orbite. Le traitement est chirurgical, consiste à une exérèse du kyste avec drainage du sinus causal

10-Year cardiovascular event risks for women who experienced hypertensive disorders in late pregnancy: the HyRAS study

ABSTRACT: BACKGROUND: Cardiovascular disease is the cause of death in 32% of women in the Netherlands. Prediction of an individual's risk for cardiovascular disease is difficult, in particular in younger women due to low sensitive and specific tests for these women. 10% to 15% of all pregnancies are complicated by hypertensive disorders, the vast majority of which develop only after 36 weeks of gestation. Preeclampsia and cardiovascular disease in later life show both features of "the metabolic syndrome" and atherosclerosis. Hypertensive disorders in pregnancy and cardiovascular disease may develop by common pathophysiologic pathways initiated by similar vascular risk factors. Vascular damage occurring during preeclampsia or gestational hypertension may contribute to the development of future cardiovascular disease, or is already present before pregnancy. At present clinicians do not systematically aim at the possible cardiovascular consequences in later life after a hypertensive pregnancy disorder at term. However, screening for risk factors after preeclampsia or gestational hypertension at term may give insight into an individual's cardiovascular risk profile. METHODS: Women with a history of preeclampsia or gestational hypertension will be invited to participate in a cohort study 2,5 years after delivery. Participants will be screened for established modifiable cardiovascular risk indicators. The primary outcome is the 10-year cardiovascular event risk. Secondary outcomes include differences in cardiovascular parameters, SNP's in glucose metabolism, and neonatal outcome. DISCUSSION: This study will provide evidence on the potential health gains of a modifiable cardiovascular risk factor screening program for women whose pregnancy was complicated by hypertension or preeclampsia. The calculation of individual 10-year cardiovascular event risks will allow identification of those women who will benefit from primary prevention by tailored interventions, at a relatively young age. Trail registration The HYPITAT trial is registered in the clinical trial register as ISRCTN08132825

Soluble fms-Like Tyrosine Kinase 1 (sFlt1), Endoglin and Placental Growth Factor (PlGF) in Preeclampsia among High Risk Pregnancies

Background: Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women. The objective of this study was to investigate whether similar changes can be detected in pregnant women at high-risk to develop the syndrome. Methods: This study is a secondary analysis of the NICHD MFMU trial of aspirin to prevent preeclampsia in high-risk pregnancies. Serum samples were available from 194 women with pre-existing diabetes, 313 with chronic hypertension, 234 with multifetal gestation, and 252 with a history of preeclampsia in a previous pregnancy. Samples collected across pregnancy were analyzed in a blinded fashion for sFlt1, sEng and PlGF. Results: The odds of developing preeclampsia were significantly increased among women with multiple fetuses for each 2- fold elevation in sFlt1, sEng and the ratio of angiogenic factors (e.g. OR 2.18, 95% CI 1.46-3.32), and significantly decreased for each 2-fold elevation in circulating PlGF (OR 0.50, 95% CI 0.30-0.82) between 7 and 26 weeks' gestation. Cross-sectional analysis of the angiogenic factors across gestation showed significant differences during the third trimester in women who develop preeclampsia compared with appropriate controls in all high-risk groups. However, when data were examined in relation to the gestational week when preeclampsia was diagnosed only sFlt1 was significantly higher 2 to 5 weeks before the clinical onset of preeclampsia and only in women with previous preeclampsia. Conclusions: The pattern of elevated concentrations of sFlt1 and sEng, and low PlGF in high-risk pregnant subjects who develop preeclampsia is similar to that reported in low-risk pregnant women. However, differences in these factors among high-risk women who do and do not develop preeclampsia are modest, and do not appear to be clinically useful predictors in these high-risk pregnant women