2,099 research outputs found
Stretched exponential relaxation in a diffusive lattice model
We studied the single dimer dynamics in a lattice diffusive model as a
function of particle density in the high densification regime. The mean square
displacement is found to be subdiffusive both in one and two dimensions. The
spatial dependence of the self part of the van Hove correlation function
displays as function of a single peak and signals a dramatic slow down of
the system for high density. The self intermediate scattering function is
fitted to the Kohlrausch-Williams-Watts law. The exponent extracted
from the fits is density independent while the relaxation time follows a
scaling law with an exponent 2.5.Comment: 5 pages, 3 figures, to be published in Phys. Rev.
Brownian forces in sheared granular matter
We present results from a series of experiments on a granular medium sheared
in a Couette geometry and show that their statistical properties can be
computed in a quantitative way from the assumption that the resultant from the
set of forces acting in the system performs a Brownian motion. The same
assumption has been utilised, with success, to describe other phenomena, such
as the Barkhausen effect in ferromagnets, and so the scheme suggests itself as
a more general description of a wider class of driven instabilities.Comment: 4 pages, 5 figures and 1 tabl
Time dependence of breakdown in a global fiber-bundle model with continuous damage
A time-dependent global fiber-bundle model of fracture with continuous damage
is formulated in terms of a set of coupled non-linear differential equations. A
first integral of this set is analytically obtained. The time evolution of the
system is studied by applying a discrete probabilistic method. Several results
are discussed emphasizing their differences with the standard time-dependent
model. The results obtained show that with this simple model a variety of
experimental observations can be qualitatively reproduced.Comment: APS style, two columns, 4 figures. To appear in Phys. Rev.
The filamentation instability driven by warm electron beams: Statistics and electric field generation
The filamentation instability of counterpropagating symmetric beams of
electrons is examined with 1D and 2D particle-in-cell (PIC) simulations, which
are oriented orthogonally to the beam velocity vector. The beams are uniform,
warm and their relative speed is mildly relativistic. The dynamics of the
filaments is examined in 2D and it is confirmed that their characteristic size
increases linearly in time. Currents orthogonal to the beam velocity vector are
driven through the magnetic and electric fields in the simulation plane. The
fields are tied to the filament boundaries and the scale size of the
flow-aligned and the perpendicular currents are thus equal. It is confirmed
that the electrostatic and the magnetic forces are equally important, when the
filamentation instability saturates in 1D. Their balance is apparently the
saturation mechanism of the filamentation instability for our initial
conditions. The electric force is relatively weaker but not negligible in the
2D simulation, where the electron temperature is set higher to reduce the
computational cost. The magnetic pressure gradient is the principal source of
the electrostatic field, when and after the instability saturates in the 1D
simulation and in the 2D simulation.Comment: 10 pages, 6 figures, accepted by the Plasma Physics and Controlled
Fusion (Special Issue EPS 2009
Sex differences in life history, behavior, and physiology along a slow-fast continuum: a meta-analysis
Tarka M, Günther A, Niemelae PT, Nakagawa S, Noble DWA. Sex differences in life history, behavior, and physiology along a slow-fast continuum: a meta-analysis. BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY. 2018;72(8): UNSP 132.The pace-of-life syndrome (POLS) hypothesis predicts that behavior and physiology covary with life history. Evidence for such covariation is contradictory, possibly because systematic sources of variation (e.g. sex) have been neglected. Sexes often experience different selection pressures leading to sex-specific allocation between reproduction and self-maintenance, facilitating divergence in life-history. Sex-specific differences in means and possibly variances may therefore play a key role in the POLS framework. We investigate whether sexes differ in means and variances along the fast-slow pace-of-life continuum for life history and physiological and behavioral traits. In addition, we test whether social and environmental characteristics such as breeding strategy, mating system, and study environment explain heterogeneity between the sexes. Using meta-analytic methods, we found that populations with a polygynous mating system or for studies conducted on wild populations, males had a faster pace-of-life for developmental life-history traits (e.g., growth rate), behavior, and physiology. In contrast, adult life-history traits (e.g., lifespan) were shifted towards faster pace-of-life in females, deviating from the other trait categories. Phenotypic variances were similar between the sexes across trait categories and were not affected by mating system or study environment. Breeding strategy did not influence sex differences in variances or means. We discuss our results in the light of sex-specific selection that might drive sex-specific differences in pace-of-life and ultimately POLS
Clostridioides difficile binary toxin binding component (cdtb) increases virulence in a hamster model
Background
Clostridioides difficile is the leading cause of hospital-acquired gastrointestinal infection, in part due to the existence of binary toxin (CDT)-expressing hypervirulent strains. Although the effects of the CDT holotoxin on disease pathogenesis have been previously studied, we sought to investigate the role of the individual components of CDT during in vivo infection.
Methods
To determine the contribution of the separate components of CDT during infection, we developed strains of C difficile expressing either CDTa or CDTb individually. We then infected both mice and hamsters with these novel mutant strains and monitored them for development of severe illness.
Results
Although expression of CDTb without CDTa did not induce significant disease in a mouse model of C difficile infection, we found that complementation of a CDT-deficient C difficile strain with CDTb alone restored virulence in a hamster model of C difficile infection.
Conclusions
Overall, this study demonstrates that the binding component of C difficile binary toxin, CDTb, contributes to virulence in a hamster model of infection
Recommended from our members
Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes
We show that natural products target proteins with a high number of protein−protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.Chemistry and Chemical Biolog
Cumulants of the three state Potts model and of nonequilibrium models with C3v symmetry
The critical behavior of two-dimensional stochastic lattice gas models with
C3v symmetry is analyzed. We study the cumulants of the order parameter for the
three state (equilibrium) Potts model and for two irreversible models whose
dynamic rules are invariant under the symmetry operations of the point group
C3v. By means of extensive numerical analysis of the phase transition we show
that irreversibility does not affect the critical behavior of the systems. In
particular we find that the Binder reduced fourth order cumulant takes a
universal value U* which is the same for the three state Potts model and for
the irreversible models. The same universal behavior is observed for the
reduced third-order cumulant.Comment: gzipped tar file containing: 1 latex file + 6 eps figure
Shear stress fluctuations in the granular liquid and solid phases
We report on experimentally observed shear stress fluctuations in both
granular solid and fluid states, showing that they are non-Gaussian at low
shear rates, reflecting the predominance of correlated structures (force
chains) in the solidlike phase, which also exhibit finite rigidity to shear.
Peaks in the rigidity and the stress distribution's skewness indicate that a
change to the force-bearing mechanism occurs at the transition to fluid
behaviour, which, it is shown, can be predicted from the behaviour of the
stress at lower shear rates. In the fluid state stress is Gaussian distributed,
suggesting that the central limit theorem holds. The fibre bundle model with
random load sharing effectively reproduces the stress distribution at the yield
point and also exhibits the exponential stress distribution anticipated from
extant work on stress propagation in granular materials.Comment: 11 pages, 3 figures, latex. Replacement adds journal reference and
addresses referee comment
Clustering and Non-Gaussian Behavior in Granular Matter
We investigate the properties of a model of granular matter consisting of
Brownian particles on a line subject to inelastic mutual collisions. This model
displays a genuine thermodynamic limit for the mean values of the energy and
the energy dissipation. When the typical relaxation time associated with
the Brownian process is small compared with the mean collision time
the spatial density is nearly homogeneous and the velocity probability
distribution is gaussian. In the opposite limit one has
strong spatial clustering, with a fractal distribution of particles, and the
velocity probability distribution strongly deviates from the gaussian one.Comment: 4 pages including 3 eps figures, LaTex, added references, corrected
typos, minimally changed contents and abstract, to published in
Phys.Rev.Lett. (tentatively on 28th of October, 1998
- …