Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. Moreover, there was no correlation (r = <0.10) between oxytocin plasma and CSF concentrations. Together, these data provide crucial insights into the plasma and CSF kinetics of intranasally administered oxytocin

Технологические решения для строительства разведочной вертикальной скважины глубиной 2520 метров на нефтяном месторождении (Томская область)

Данная работа содержит следующие ключевые слова: буровая установка, бурение, буровой раствор, заканчивание скважин, скважина, нефть охрана окружающей среды, ресурсоффективность. Объектом исследования является разведочная вертикальная скважина глубиной 2540 метров на нефтегазовом месторождении (Томская область). Целью работы является – спроектировать технологические решения для бурения вертикальной разведочной скважины глубиной 2540 м на месторождении Томской области.This work contains the following keywords: rig, drilling, drilling mud, well completion, well, oil, environmental protection, resource efficiency. The object of the study is a vertical exploration well with a depth of 2540 meters in an oil and gas field (Tomsk region). The aim of the work is to design technological solutions for drilling a vertical exploration well with a depth of 2540 m in the field of the Tomsk region

The quest for companions to post-common envelope binaries: I. Searching a sample of stars from the CSS and SDSS

As part of an ongoing collaboration between student groups at high schools and professional astronomers, we have searched for the presence of circum-binary planets in a bona-fide unbiased sample of twelve post-common envelope binaries (PCEBs) from the Catalina Sky Survey (CSS) and the Sloan Digital Sky Survey (SDSS). Although the present ephemerides are significantly more accurate than previous ones, we find no clear evidence for orbital period variations between 2005 and 2011 or during the 2011 observing season. The sparse long-term coverage still permits O-C variations with a period of years and an amplitude of tens of seconds, as found in other systems. Our observations provide the basis for future inferences about the frequency with which planet-sized or brown-dwarf companions have either formed in these evolved systems or survived the common envelope (CE) phase.Comment: accepted by A&