25-hydroxyvitamin D levels are low but not associated with disease activity in chronic spontaneous urticaria and depression

AIM: To evaluate vitamin D levels in patients with chronic spontaneous urticaria (CSU), depression and both of them, thus to fi nd out whether vitamin D may be a common causative factor of CSU and depression. METHODS: Thirty patients with CSU, 30 patients with depression, 30 patients with both CSU and depression and 30 healthy volunteers as control group were involved in the study. Serum 25-hydroxyvitamin D (25(OH) D) levels of these groups were measured and compared. Correlations between 25(OH)D levels and the activity of CSU and depression were analyzed. RESULTS: Healthy controls' 25(OH)D levels (17.2±8.8 ng/mL) were higher than patients with CSU (9.1±5.1 ng/mL), depression (8.9±6.1 ng/mL) and CSU with depression (7.7±4.7 ng/mL) (p<0.001, p<0.001 and p<0.001, respectively). There were no differences in 25(OH)D levels between CSU patients with and without depression, between depression patients and CSU patients with and without depression (p=0.43, p=0.82 and p=0.92, respectively). There were no correlations between 25(OH)D levels and the activity of CSU or depression (p=0.99 and p=0.76, respectively). CONCLUSION: Lower 25(OH)D levels in CSU and/or depression may appear as a secondary phenomenon, which means being result of these diseases rather than the cause (Tab. 1, Fig. 2, Ref. 41). © 2020 Comenius University.2-s2.0-85090930348PubMed: 3299001

Examination of IL-1β level as an inflammasome marker in Alzheimer's disease

Objective: Interleukin (IL)-1 beta is believed to be responsible for the neurotoxicity of amyloid plaques in Alzheimer's disease (AD). In the present study, serum levels of IL-1 beta, and correlations with clinical features and neuropsychiatric test results were examined

CCD UBV photometric study of five open clusters-Dolidze 36, NGC 6728, NGC 6800, NGC 7209, and Platais 1

In this study, we present CCD UBV photometry of poorly studied open star clusters, Dolidze 36, NGC 6728, NGC 6800, NGC 7209, and Platais 1, located in the first and second Galactic quadrants. Observations were obtained with T100, the 1-m telescope of the TBA degrees TAK National Observatory. Using photometric data, we determined several astrophysical parameters such as reddening, distance, metallicity and ages and from them, initial mass functions, integrated magnitudes and colours. We took into account the proper motions of the observed stars to calculate the membership probabilities. The colour excesses and metallicities were determined independently using two-colour diagrams. After obtaining the colour excesses of the clusters Dolidze 36, NGC 6728, NGC 6800, NGC 7209, and Platais 1 as , , , , and mag, respectively, the metallicities are found to be , , , , and dex, respectively. Furthermore, using these parameters, distance moduli and age of the clusters were also calculated from colour-magnitude diagrams simultaneously using PARSEC theoretical models. The distances to the clusters Dolidze 36, NGC 6728, NGC 6800, NGC 7209, and Platais 1 are , , , , and pc, respectively, while corresponding ages are , , , , and Myr, respectively. Our results are compatible with those found in previous studies. The mass function of each cluster is derived. The slopes of the mass functions of the open clusters range from 1.31 to 1.58, which are in agreement with Salpeter's initial mass function. We also found integrated absolute magnitudes varying from -4.08 to -3.40 for the clusters