Prapovijesno naselje na Kosovcu kod Bregane (Samobor)

U radu se donose rezultati pokusnog iskopavanja na gradini Bregana-Kosovac koje je proveo Odsjek za arheologiju Filozofskog fakulteta Sveučilišta u Zagrebu 1996. godine. Preliminarno se datiraju nalazi i ponovo se vrednuju ranije donešeni zaključci u starijoj literaturi

Nalazi kalupa s lokaliteta Kalnik-Igrišće kao primjer metalurške djelatnosti kasnog brončanog doba u sjeverozapadnoj Hrvatskoj

U radu je obrađena grupa nalaza koja ukazuje na postojanje metalurške djelatnosti na lokalitetu Kalnik-Igrišće. U istraženome dijelu kasnobrončanodobnog naselja iz vremena grupe Zagreb (12. i 11. st. pr. Kr.) pronađeno je nekoliko ulomaka kamenih kalupa za lijevanje metala, troska i kanelirani kamen. Svi nalazi koncentrirani su oko 7 ognjišta

Tipološka klasifikacija kasnobrončane keramike iz naselja Kalnik-Igrišče (SZ Hrvatska)

Rad donosi rezultate tipološke i statističke obrade keramičkih nalaza iz kasnobrončanodobnog naselja Kalnik-Igrišče. Uz pomoć računala stvoren je sistem dokumentacije, analize i tipološke klasifikacije keramike. Definirani tipovi uspoređuju se sa srodnim nalazima u srednjoj Evropi, posebno s nalazima iz Transdanubije, Donje Austrije i Gradišća, jugozapadne Slovačke i Moravske

Automatic Generation Control Application for Transmission and Generation Centres

Recently, a new Emergency Control Centre for Albanian Transmission System Operator (TSO), which includes Supervisory control and data acquisition (SCADA) and Automatic Generation Control (AGC) applications, has been commissioned. Nowadays, an AGC application is being prepared for the biggest generation company in Croatia, as part of control centre for hydropower plants within western part of Croatia. Both of these implementations use the same AGC application, which is presented in this paper. Although AGC for TSO and AGC for Generation Centre (GC) have many similarities, their main goals are different. AGC for TSO must mainly regulate system’s frequency and area’s active power interchange to their desired values, using only power plants engaged in load-frequency control (LFC). However, AGC for GC must ensure that power production of each power unit not engaged in LFC tracks its planned value, while also ensuring that centre’s share in LFC is being respected. Albeit the AGC is standalone application, in both afore-mentioned implementations it is affiliated with SCADA application, from which it obtains all required input measurements and indications and to which it delivers calculated setpoints. Additionally, all AGC pictures are integrated into SCADA pictures as well, in order to simplify operation and monitoring functionalities. AGC for Albanian TSO controls active power generation of six hydro power plants engaged in LFC. AGC for GC West in Croatia controls active power generation of ten hydro power plants. In both implementations, communication with remote objects is done using IEC 60870-5-104 communication protocol, while communication with other control centres is done using ICCP communication protocol. Power production plans are sent to AGC either from Market Management Systems (in TSO case) or from scheduling and optimization application (in GC case

New Mediterranean Biodiversity Records (December 2017)

The “New Mediterranean Biodiversity Records” series includes new records of marine species found in the Mediterranean basin and/or information on the spatial distribution of already established species of particular interest. The current article presents information on 20 marine taxa classified per country according to their geographic position in the Mediterranean, from west to east. The new records per ecoregion are as follows: Algeria: the first record of the fish Etrumeus golanii is reported along the Algerian coast. Tunisia: the alien jellyfish Phyllorhiza punctata is reported for the first time in the Gulf of Gabès. Italy: the first record of Siganus rivulatus in the Strait of Sicily and a new record of Katsuwonus pelamis from the central Tyrrhenian Sea are reported. The establishment of the isopod of the genus Mesanthura in the northern Tyrrhenian with some notes on its ecology are also included. Croatia: signs of establishment of the Lessepsian Siganus luridus and the occurrence of the alien mollusc Rapana venosa are reported. Albania: the first record of the elasmobranch Alopias superciliosus and a recent sighting of the rare monk seal Monachus monachus in Albanian waters are given. Greece: signs of the establishment of the fish Parupeneus forsskali and of the ascidian Hermania momus in Hellenic Aegean waters are reported. Turkey: a new record of the fish P. forsskali and of the Acarea of the genus Acaromantis and Simognathus are given, while the first case of Remora australis in association with delphinids and the occurrence of the sea star Coscinasterias tenuispina are reported. Also, the establishment of the two alien species Isognomon legumen and Viriola sp. [cf. corrugata] are presented. Egypt: the fish Bathygobius cyclopterus is reported for the first time in Mediterranean Sea waters. Also, a new record of Pagellus bogaraveo and a first record of Seriola fasciata in Egyptian Mediterranean waters are reported. Lebanon: the first record of Dondice banyulensis is presented

Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice

BACKGROUND: Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculature, however the stratum corneum (SC), must be breached for successful vaccination. This has been achieved by removing the SC by abrasion or scarification or by delivering the vaccine intradermally (ID) with traditional needle-and-syringes or with long microneedle devices. Microneedle patch-based transdermal vaccine studies have predominantly focused on antibody induction by inactivated or subunit vaccines. Here, our principal aim is to determine if the design of a microneedle patch affects the CD8(+) T cell responses to a malaria antigen induced by a live vaccine. METHODOLOGY AND FINDINGS: Recombinant modified vaccinia virus Ankara (MVA) expressing a malaria antigen was percutaneously administered to mice using a range of silicon microneedle patches, termed ImmuPatch, that differed in microneedle height, density, patch area and total pore volume. We demonstrate that microneedle arrays that have small total pore volumes induce a significantly greater proportion of central memory T cells that vigorously expand to secondary immunization. Microneedle-mediated vaccine priming induced significantly greater T cell immunity post-boost and equivalent protection against malaria challenge compared to ID vaccination. Notably, unlike ID administration, ImmuPatch-mediated vaccination did not induce inflammatory responses at the site of immunization or in draining lymph nodes. CONCLUSIONS/SIGNIFICANCE: This study demonstrates that the design of microneedle patches significantly influences the magnitude and memory of vaccine-induced CD8(+) T cell responses and can be optimised for the induction of desired immune responses. Furthermore, ImmuPatch-mediated delivery may be of benefit to reducing unwanted vaccine reactogenicity. In addition to the advantages of low cost and lack of pain, the development of optimised microneedle array designs for the induction of T cell responses by live vaccines aids the development of solutions to current obstacles of immunization programmes