842 research outputs found

    Sequence variation among heavy chains from inulin-binding myeloma proteins

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    Model-independent resonance parameter extraction using the trace of K and T matrices

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    A model-independent method for the determination of Breit-Wigner resonance parameters is presented. The method is based on eliminating the dependence on the choice of channel basis by analyzing the trace of the K and T matrices in the coupled-channel formalism, rather than individual matrix elements of the multichannel scattering matrix.Comment: 6 pages, 16 figure

    The reaction pi N to pi pi N in a meson-exchange approach

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    A resonance model for two-pion production in the pion-nucleon reaction is developed that includes information obtained in the analysis of pion-nucleon scattering in a meson-exchange model. The baryonic resonances Delta(1232), N*(1440), N*(1520), N*(1535), and N*(1650) are included. The model reproduces the total cross sections up to kinetic energies of the incident pion of 350 MeV and obtains the shapes of the differential cross sections in reasonable agreement with the data.Comment: 7 pages, 7 figures, 2 table

    Gene expression changes following extinction testing in a heroin behavioral incubation model

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    <p>Abstract</p> <p>Background</p> <p>A number of gene expression studies have investigated changes induced by drug exposure, but few reports describe changes that persist following relapse. In this study, genome-wide analysis of gene expression was conducted following an extinction session (90 min) in rats that expressed behavioral incubation of heroin-seeking and goal-directed behavior. As an important modulator of goal-directed behavior, the medial prefrontal cortex (mPFC) was the target of genomic analysis. Rats were trained to self-administer heroin during 3 h daily sessions for 14 d. Following the self-administration period, rats were reintroduced to the self-administration chambers for a 90-minute extinction session in which they could seek heroin, but received none. Extinction sessions were conducted on groups after either 1 d or 14 d of drug-free enforced abstinence to demonstrate behavioral incubation.</p> <p>Results</p> <p>Behavioral data demonstrated incubation (increased expression) of heroin-seeking and goal-directed behavior after the 14 d abstinent period. That is, following 14 d of enforced abstinence, animals displayed heightened drug-seeking behavior when returned to the environment where they had previously received heroin. This increased drug-seeking took place despite the fact that they received no drug during this extinction session. Whole genome gene expression analysis was performed and results were confirmed by quantitative real-time PCR (RT-qPCR). Microarrays identified 66 genes whose expression was identified as changed by at least 1.4 fold (p < 0.02) following 14 d of abstinence and the 90-minute extinction session compared to the saline treated controls. Orthogonal confirmation by RT-qPCR demonstrated significant alterations in <it>bdnf</it>, <it>calb1</it>, <it>dusp5</it>, <it>dusp6</it>, <it>egr1</it>, <it>npy</it>, <it>rgs2</it>.</p> <p>Conclusion</p> <p>Ontological analysis indicates that several of the genes confirmed to be changed are important for neuroplasticity, and through that role may impact learning and behavior. The importance of drug-seeking behavior and memory of previous drug-taking sessions suggest that such genes may be important for relapse. The global gene expression analysis adds to the knowledge of heroin-induced changes and further highlights similarities between heroin and other drugs of abuse.</p

    Kaon photoproduction: background contributions, form factors and missing resonances

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    The photoproduction p(gamma, K+)Lambda process is studied within a field-theoretic approach. It is shown that the background contributions constitute an important part of the reaction dynamics. We compare predictions obtained with three plausible techniques for dealing with these background contributions. It appears that the extracted resonance parameters drastically depend on the applied technique. We investigate the implications of the corrections to the functional form of the hadronic form factor in the contact term, recently suggested by Davidson and Workman (Phys. Rev. C 63, 025210). The role of background contributions and hadronic form factors for the identification of the quantum numbers of ``missing'' resonances is discussed.Comment: 11 pages, 7 eps figures, submitted to Phys. Rev.

    Explicit Orbit Classification of Reducible Jordan Algebras and Freudenthal Triple Systems

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    We determine explicit orbit representatives of reducible Jordan algebras and of their corresponding Freudenthal triple systems. This work has direct application to the classification of extremal black hole solutions of N = 2, 4 locally supersymmetric theories of gravity coupled to an arbitrary number of Abelian vector multiplets in D = 4, 5 space-time dimensions.Comment: 18 pages. Updated to match published versio

    Model dependence of single-energy fits to pion photoproduction data

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    Model dependence of multipole analysis has been explored through energy-dependent and single-energy fits to pion photoproduction data. The MAID energy-dependent solution has been used as input for an event generator producing realistic pseudo data. These were fitted using the SAID parametrization approach to determine single-energy and energy-dependent solutions over a range of lab photon energies from 200 to 1200 MeV. The resulting solutions were found to be consistent with the input amplitudes from MAID. Fits with a χ\chi-squared per datum of unity or less were generally achieved. We discuss energy regions where consistent results are expected, and explore the sensitivity of fits to the number of included single- and double-polarization observables. The influence of Watson's theorem is examined in detail.Comment: 12 pages, 8 figure
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