The effective gravitational decoupling between dark matter and the CMB

We present a detailed and self-contained analytical derivation of the evolution of sub-horizon cosmological perturbations before decoupling, based on previous work by S. Weinberg. These solutions are valid in the minimal LCDM scenario, to first order in perturbation theory, in the tight-coupling limit and neglecting neutrino shear stress. We compare them to exact numerical solutions computed by a Boltzmann code, and we find the two to be in very good agreement. The analytic solutions show explicitly that CDM and the baryon-photon fluid effectively behave as separate self-gravitating fluids until the epoch of baryon drag. This in turn leads to the surprising conclusion that the CMB is much less sensitive to the clustering properties of minimally coupled Dark Matter models than what would be naively expected.Comment: 23 pages, 8 figures, 2 references added, few sentences clarifie

Ambérieu-en-Bugey – Grotte du Gardon

La septième campagne de fouille archéologique dans la grotte du Gardon s’est déroulée sur onze semaines. Elle a été complétée par un important travail de publications, dont sept articles scientifiques et un ouvrage collectif, le précédent « Rapport 1985-1990 », publié à compte d’auteur à Genève. Plusieurs exposés en colloque et plusieurs conférences publiques ont assuré de plus la diffusion des premiers résultats. Sur le terrain, la fouille a concerné quatre zones principales : L’ouverture d’..

Psychoanalysis and the law beyond the Oedipus : a study in legal fictions.

PhDThe present thesis considers the function of law in the political from the perspective of psychoanalysis, a discipline which foregrounds the subject. Drawing from the Lacanian contributions to psychoanalytic theory, I begin by assessing the validity of the Oedipal hypothesis for the purposes of understanding the dynamics of collective life. My analysis of civilisation in psychoanalytic terms will expose the subject as the seat of 'certain key phenomena which, despite their deeply intimate character, play themselves out in the field of law, in the confines of the institution, or again in the political realm: essentially, culpability, belief and love. I will argue that, although these phenomena irretrievably obstruct the rational unfolding of discourse, they also impel the precipitation of the subject's attachment to the political, and permit the consolidation thereof through the medium of transference. Yet, and in contradistinction to other strands of psychoanalytic jurisprudence, in this work psychoanalysis will be used neither as an hermeneutic tool nor as an analogical model. Indeed, my purpose is to evidence the existence of a certain continuity between the unconscious as discourse and the political order. This continuity between the unconscious and the political will be presented in terms of the logic of exception, which structures the subject's relation to language, and which Lacan identified as the structural core of the Oedipus complex. I will then apply Lacan's hypothesis of the exceptional structure of discourse to the theories of three political thinkers, chosen for the distinctness of their approach: Legendre, Bentham and Foucault. Finally, I will argue for the dispensability of the function of the Ideal, parasitic occupier of what should remain the structurally `empty' place of exception

Alleyrac – Le Bourg (souterrain de Choumazel)

Identifiant de l'opération archéologique : 2007/60 Date de l'opération : 2007 (SD) La commune d’Alleyrac a effectué des travaux d’assainissement occasionnant d’importantes tranchées. Le 19 décembre 2006, le chantier est arrêté en raison de la découverte d’une cavité creusée dans la pouzzolane (en occitan « la chisse ») et dans le basalte, depuis un mètre sous la route jusqu’à trois mètres de profondeur. Un grand nombre de souterrains est connu en Velay, dont certains ont été fouillés, il y a ..

Los Soprano: la "famiglia" como S1

El nombre mismo de la serie, Los Soprano, dice claramente que se trata de un apellido familiar. La familia opera como el S1 de la serie, ya sea que se trate de la familia en el sentido extendido de la cultura mafiosa o bien de la familia en el sentido propio del término. La Dra. Melfi, llevada por su deseo terapéutico, desde la primera sesión pone el dedo en el S1 de Tony, pero luego se verá ella misma arrastrada por la lógica serial, y en la segunda temporada se hace evidente la decadencia de un tratamiento que prescinde de toda ética

Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine.

Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very rare lymphoma with an aggressive clinical course and a dismal outcome. The prognosis is linked to a pronounced resistance to chemotherapy and radiotherapy. No standard treatment approach is defined due to the low frequency of the disease and lack of prospective studies. CD30 is expressed in almost half of the cases of PCGD-TCL, which offers a potential therapeutic option. We report the successful treatment of a 68-year-old man who suffered PCGD-TCL with a combination of Brentuximab Vedotin and Gemcitabine after the failure of two lines of previous chemotherapy. CD30 expression was only partial. The treatment was very well tolerated and allowed the patient to benefit from allogeneic hematopoietic stem cell transplantation

Alleyrac – Le Bourg (souterrain de Choumazel)

Identifiant de l'opération archéologique : 2007/60 Date de l'opération : 2007 (SD) La commune d’Alleyrac a effectué des travaux d’assainissement occasionnant d’importantes tranchées. Le 19 décembre 2006, le chantier est arrêté en raison de la découverte d’une cavité creusée dans la pouzzolane (en occitan « la chisse ») et dans le basalte, depuis un mètre sous la route jusqu’à trois mètres de profondeur. Un grand nombre de souterrains est connu en Velay, dont certains ont été fouillés, il y a ..

Explicit and Implicit Emotion Processing in the Cerebellum: A Meta‑analysis and Systematic Review

The cerebellum’s role in affective processing is increasingly recognized in the literature, but remains poorly understood, despite abundant clinical evidence for affective disruptions following cerebellar damage. To improve the characterization of emotion processing and investigate how attention allocation impacts this processing, we conducted a meta-analysis on task activation foci using GingerALE software. Eighty human neuroimaging studies of emotion including 2761 participants identified through Web of Science and ProQuest databases were analyzed collectively and then divided into two categories based on the focus of attention during the task: explicit or implicit emotion processing. The results examining the explicit emotion tasks identified clusters within the posterior cerebellar hemispheres (bilateral lobule VI/Crus I/II), the vermis, and left lobule V/VI that were likely to be activated across studies, while implicit tasks activated clusters including bilateral lobules VI/Crus I/II, right Crus II/lobule VIII, anterior lobule VI, and lobules I-IV/V. A direct comparison between these categories revealed five overlapping clusters in right lobules VI/Crus I/Crus II and left lobules V/VI/Crus I of the cerebellum common to both the explicit and implicit task contrasts. There were also three clusters activated significantly more for explicit emotion tasks compared to implicit tasks (right lobule VI, left lobule VI/vermis), and one cluster activated more for implicit than explicit tasks (left lobule VI). These findings support previous studies indicating affective processing activates both the lateral hemispheric lobules and the vermis of the cerebellum. The common and distinct activation of posterior cerebellar regions by tasks with explicit and implicit attention demonstrates the supportive role of this structure in recognizing, appraising, and reacting to emotional stimuli

Les sites de hauteur du Velay, de 1400 à 450 av. J.-C.

L’objet de cet article repose sur la synthèse des connaissances relatives aux sites de hauteur connus dans le Velay pour leur fréquentation au cours du Bronze final et du Premier âge du Fer. Parmi eux, cinq sites ont seulement fourni du mobilier et trois occupations sont documentées par des structures en place. Un seul site, doté d’un rempart, est présentement fouillé, le rocher du Largier à Lafarre. Il présente un mobilier typique de la phase Hallstatt final – Tène ancienne (Ha D2-D3 – LTA, vers 500 à 450 av. J.-C.), et quelques indices de fréquentation de La Tène finale, vers 100 av. J. -C.This article focuses on a synthesis of knowledge relating to sites on height, known in the Velay for their human activity during the Late Bronze Age and the Early Iron Age. Among them, five sites produced materials and three sites are revealed by existing structures. Only one site, Le Rocher du Largier in Lafarre, presenting a bulwark, is currently excavated. It produced typical materials from Late Hallstatt period - ancient La Tène (HA D2-D3 - LTA, around 500 to 450 BC), and showed some evidence of activity from Late La Tène, around 100 BC

Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript.

Relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) has a very poor prognosis with a median overall survival of four to nine months. Achieving a complete molecular response is most often required to obtain a sustained leukemia-free survival after allogeneic hematopoietic stem cell transplantation. Immunotherapies targeting CD19, CD20, or CD22 are very efficient in achieving this goal. However, in the absence of the expression of these immunotherapeutic targets by lymphoblasts, treatment options are extremely scarce. We report the successful treatment of a 26-year-old man who suffered R/R, CD19, CD20, and CD22 negative B-ALL targeting Bcl-2 and CD38 by combining venetoclax and daratumumab with chemotherapy