Creation science and technology parks as a component of innovation in economic development

The article is devoted to the functioning of technology and science parks in developed economies. The analysis of scholarly works on problem creates innovative structures in the national economy. The role of technology and science parks as innovative component of the state economy is defined. The experience of the world's leading science and technology parks in various developed economies: the experience of the United Kingdom, Singapore, India, the United States and China. The basic ingredients for success in creating innovative structures in national economies and the factors that require further study

Strain-Hardening Stages and Structure Evolution in Pure Niobium and Vanadium upon High Pressure Torsion

High pressure torsion (HPT) is one of the ways to form nanostructured materials with high strength properties. However, HPT hardening mechanisms vary from material to material and are poorly understood for some BCC metals, particularly niobium and vanadium. This work aims to identify strain hardening stages for Nb and V metals during HPT. Two approaches have been used to identify the deformation stages during high pressure torsion. The approaches are based on the application of a "piecewise" model, taking into account the different deformation mechanisms that determine the type of the forming structure, and on the analysis of the hardness vs. true strain dependence according to the $H$$-$${e}^{0.5}$ law. We compared the identified stages with the results of the electron microscopic study of the structure. Both models describe well the structural changes observed microscopically in HPT-deformed niobium. However, we have shown that only the piecewise model gives an adequate description of the stages of structure development in vanadium. We have provided an explanation for the observed difference in the behavior of niobium and vanadium upon HPT.Comment: 21 pages, 9 figures, 1 tabl

Characterization of a novel dioxomolybdenum complex by cyclic voltammetry

Metalloenzymes that carry a pterin-based molybdenum cofactor in their center catalyze numerous reactions in the human body and play a crucial role in its metabolism. Specifically, these enzymes promote redox reactions and oxygen transport in the body. Their absence may cause many problems leading to disability or even death in early childhood. Therefore, model compounds need to be synthesized and analyzed to investigate the reactivity, redox potential, and geometry of these cofactors. This study focused on electrode processes and determined the redox potentials of the new bis-(4-mercapto-5-(p-tolyl)-3H-1,2-dithiole-3-thione)-dioxomolybdenum complex by cyclic voltammetry. The 4-mercapto-5-(p-tolyl)-3H-1,2-dithiole-3-thione ligand underwent irreversible oxidation and reduction at thiol and thione functional groups. The new dioxomolybdenum complex showed a quasi-reversible two-stage electrode process

АНАЛИЗ ЗАКОНОДАТЕЛЬСТВА ПО ОГРАНИЧЕННОМУ ПОЛЬЗОВАНИЮ (СЕРВИТУТУ) ЗЕМЕЛЬНЫМ УЧАСТКОМ

The article makes an attempt to analyze proprietary rights on land, to compare legal regulations on forming a land plot and registering it in Russia. System characteristics are studied: rights on a land plot, land plot definition, possible versions of its changing in terms of owning property, cadastral registration, limitation of rights of using a land plot (servitude). Problems connected with servitudes and land plot usage modes are defined and approach to solving them is suggested.В статье сделана попытка проанализировать вещные права на землю, сопоставить положения законодательства об образовании земельного участка и его регистрации в России. Рассматриваются системные характеристики: права на земельный участок, определение земельного участка, возможные варианты его изменения с точки зрения владения имуществом, кадастровый учет, ограничения прав пользования земельным участком (сервитут). Определены проблемы, связанные с сервитутами и режимами пользования земельными участками, и предложен подход к их решению

ИСПЫТАНИЯ ЦИСТЕРН ИЗБЫТОЧНЫМ ДАВЛЕНИЕМ

The updated testing stand permits verification of design of tank cars by overpressure. The appropriate methods ensure assessment of high-cycle intense actions on the tank after welding, as well as effective control of welded joints safety and critical loads.Усовершенствованный испытательный стенд позволяет успешно проводить проверку конструкций вагонов-цистерн избыточным давлением. Разработанная для этого методика обеспечивает оценку многоцикловых интенсивных воздействий на котлы после сварочных работ, контроль безопасности швов и предельных нагрузок

О МОДЕРНИЗАЦИИ ВАГОНОВ-ЦИСТЕРН

The authors argue that updating of the design of specialized railway cars and innovation management of freight companies are indispensable for quality service for transport clients, higher competitiveness of transportation cargo facilities and rational market oriented rail freightageСоблюдение интересов потребителей транспортной продукции, повышение конкурентоспособности транспортно- грузовых комплексов, рациональная перевозка предлагаемых рынком грузов невозможны без модернизации конструкций специализированных вагонов, наличия в грузовых компаниях инновационного управления

АНАЛИЗ ЗАКОНОДАТЕЛЬСТВА ПО ОГРАНИЧЕННОМУ ПОЛЬЗОВАНИЮ (СЕРВИТУТУ) ЗЕМЕЛЬНЫМ УЧАСТКОМ

The article makes an attempt to analyze proprietary rights on land, to compare legal regulations on forming a land plot and registering it in Russia. System characteristics are studied: rights on a land plot, land plot definition, possible versions of its changing in terms of owning property, cadastral registration, limitation of rights of using a land plot (servitude). Problems connected with servitudes and land plot usage modes are defined and approach to solving them is suggested.В статье сделана попытка проанализировать вещные права на землю, сопоставить положения законодательства об образовании земельного участка и его регистрации в России. Рассматриваются системные характеристики: права на земельный участок, определение земельного участка, возможные варианты его изменения с точки зрения владения имуществом, кадастровый учет, ограничения прав пользования земельным участком (сервитут). Определены проблемы, связанные с сервитутами и режимами пользования земельными участками, и предложен подход к их решению

Live Birth of a Healthy Child in a Couple with Identical mtDNA Carrying a Pathogenic c.471_477delTTTAAAAinsG Variant in the MOCS2 Gene.

Molybdenum cofactor deficiency type B (MOCODB; #252160) is an autosomal recessive metabolic disorder that has only been described in 37 affected patients. In this report, we describe the presence of an in-frame homozygous variant (c.471_477delTTTAAAAinsG) in the MOCS2 gene in an affected child, diagnosed with Ohtahara syndrome according to the clinical manifestations. The analysis of the three-dimensional structure of the protein and the amino acid substitutions suggested the pathogenicity of this mutation. To prevent transmitting this mutation to the next generation, we used preimplantation genetic testing for the monogenic disorders (PGT-M) protocol to select MOCS2 gene mutant-free embryos for transfer in an in vitro fertilization (IVF) program. As a result, a healthy child was born. Interestingly, both parents of the proband shared an identical mitochondrial (mt) DNA control region, assuming their close relationship and thus suggesting that both copies of the nuclear rare variant c.471_477delTTTAAAAinsG may have been transmitted from the same female ancestor. Our estimation of the a priori probability of meeting individuals with the same mtDNA haplotype confirms the assumption of a possible distant maternal relationship among the proband's direct relatives