Sex, Ethnicity, and Socioeconomic Status on Attitudes Toward Women As Managers and Perceived Career Impediment: A Study of Young Adults In Malaysia

The current study aims at examining the effects of sex, race, and socioeconomic status on young Malaysians; attitudes toward women as managers and the perceived barriers to their own careers. This paper also examined a moderated mediation, with the moderator being the working status of an individual\u27s mother and the mediator being gender role attitudes. A great wealth of research in this area has been conducted in the Western culture, but much less is known about Malaysia and its young adults. This study provides a historical and sociocultural overview of Malaysia, and how its unique sociopolitical and societal structure impacts the relationships among the variables. Results indicated that women have more favorable and positive attitudes toward women as managers than their male counterparts; individuals who have higher socioeconomic status have more favorable and positive attitudes toward women as managers, and individuals with higher socioeconomic status also seem to perceive fewer barriers to employment than those with lower socioeconomic status. Results also indicated that contrary to what previous literature have demonstrated, the working status of an individual\u27s mother did not play a significant role in the relationship of the examined variables. This paper also discusses some practical implications for policy makers and organizations

e-Integral map as an interactive procedural learning tool / Nor Hazizah Julaihi, Voon Li Li and Tang Howe Eng

In higher learning institutions, students have been learning Calculus conventionally from textbook or reference book which they perceived as abstract, confusing and cannot be imagined. Available books are too complicated for fast revision, too complex for identification of appropriate technique(s) to solve Calculus problems and fail to provide a thorough overview on the content learned. This study proposes e-lntegral Map which provides an alternative way for the learners to learn Calculus interactively. This study attempts to investigate the effectiveness of using e-lntegral Map in Calculus learning among higher learning institutions students. Students' understanding and students' feedback while and after using e-lntegral Map are also investigated in this study, e-lntegral Map provides a rich learning experience to cater the different abilities of students in learning Calculus. This study employs mixed methods research design in which quantitative procedures that involve the uses of questionnaires, pre-test and post-test, is the initial method of collecting data and follow-up by the collection of interview data to provide in-depth information of the quantitative findings. A total of 55 higher learning institution students will be selected by using the stratified random sampling method. The sample will be randomly assigned to treatment and control groups. Six respondents will then be interviewed to tackle the learning process and the experience of the students while using e-lntegral map. The findings will then be analyzed. The expected outcomes from this study comprise an innovative and new teaching and learning method to assist students' in learning Calculus

Misconceptions and errors in learning integral calculus / Voon Li Li, Nor Hazizah Julaihi and Tang Howe Eng

The paper presents the results of a case study examining students’ difficulties in the learning of integral calculus. It sought to address the misconceptions and errors that were encountered in the students’ work solution. In quantitative study, the marks obtained by 147 students of Diploma in Computer Science in advanced calculus examinations were used as a measurement to evaluate the percentages of errors. Further, qualitative study examined the types of errors performed by 70 diploma students of the advanced calculus courses in their on-going assessments. The students encountered more difficulties in solving questions related to improper integrals for standard functions (63.1 percentages of errors). The three techniques of integration, namely by parts, trigonometric substitution and partial fraction with combined percentage errors of 42.8 also contributed to this. The types of conceptual errors discovered are symbolic, standard functions recognition, property of integral and technique determination. The procedural errors are due to the confusion between differentiation and integration process while the technical errors have foreseen the students struggling with poor mathematical skills and carelessness. The results will thus be useful to Mathematics educators who are keen in designing functional teaching and learning instruments to rectify the difficulties and misconceptions problems experienced by calculus students

Attitudes and perceptions of university students towards calculus / Tang Howe Eng, Nor Hazizah Julaihi and Voon Li Li

This study seeks to examine university students’ attitudes and their perceptions on calculus education. Lecturers’ suggestions to remedy the current situation of calculus learning were also investigated. The instruments of this study consisted of three sets of questionnaires, aimed at collecting data regarding students’ attitudes and perceptions on calculus and lecturers’ suggestions. The respondents consisted of 278 full-time diploma students in a public university in Malaysia. The findings indicate that the students’ attitudes towards the Course of calculus according to gender were insignificant. However, there was a significant difference in the students’ attitudes towards the Field of calculus between female and male students. Students of Pre-Calculus and Calculus I were found to be feeling, thinking, and behaving similarly about calculus. Their attitudes towards the Field of calculus among the four engineering and science programmes were significant. After attempting 39.27% of the given questions, students’ perceptions on the difficulty of the questions remained the same, which was neither easier nor harder than they expected. Nevertheless, students’ perceptions changed positively (questions more difficult than expected) in 19.45% of the questions and negatively (questions easier than expected) in 41.28% of the questions. The implications from these findings provided inputs to improve calculus teaching and learning. Information regarding students’ attitudes toward calculus could help lecturers to design comprehensive calculus lessons that suit all kinds of students. Students also need to change their attitudes towards calculus, for example by having a closer inspection of the exact nature of the calculus questions before attempting them

Twice-Daily Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex Reduces Methamphetamine Craving: A Pilot Study.

Transcranial magnetic stimulation (TMS) holds potential promise as a therapeutic modality for disorders of addiction. Our previous findings indicate that high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsal-lateral prefrontal cortex (DLPFC) and low-frequency rTMS over the right DLPFC can reduce drug craving for methamphetamine. One major issue with rTMS is the duration of treatment and hence potential dropout rate. Theta burst stimulation (TBS) has been recently shown to be non-inferior relative to repetitive transcranial magnetic stimulation for major depression. Here, we aim to compare the clinical efficacy and tolerability of intermittent and continuous theta burst stimulation protocols targeting left or right dorsolateral prefrontal cortex on methamphetamine craving in abstinent-dependent subjects. In this randomized single-blind pilot study, 83 abstinent methamphetamine-dependent subjects from a long-term residential treatment program were randomly allocated into three groups: intermittent theta burst stimulation (iTBS) over the left DLPFC (active group), continuous theta burst stimulation (cTBS) over the left DLPFC (active control group), or cTBS over the right DLPFC (active group) was administered twice daily over 5 days for a total of 10 sessions. We measured the primary outcome of cue-induced craving and secondarily sleep quality, depression, anxiety, impulsivity scores, and adverse effects. We show a pre- vs. postintervention effect on craving, which, on paired t tests, showed that the effect was driven by iTBS of the left DLPFC and cTBS of the right DLPFC, reducing cue-induced craving but not cTBS of the left DLPFC. We did not show the critical group-by-time interaction. The secondary outcomes of depression, anxiety, and sleep were unrelated to the improvement in craving in the left iTBS and right cTBS group. In the first two sessions, self-reported adverse effects were higher with left iTBS when compared to right cTBS. The distribution of craving change suggested greater clinical response (50% improvement) with right cTBS and a bimodal pattern of effect with left iTBS, suggesting high interindividual variable response in the latter. Accelerated twice-daily TBS appears feasible and tolerable at modulating craving and mood changes in abstinent methamphetamine dependence critically while reducing session length. We emphasize the need for a larger randomized controlled trial study with a sham control to confirm these findings and longer duration of clinically relevant follow-up. Chinese Clinical Trial Registry number, 17013610

Habenular Stimulation for Neurosurgery Resistant Obsessive-Compulsive Disorder: A Case Report.

BACKGROUND: Some patients suffer from persistent and severely disabling Obsessive-Compulsive Disorder (OCD) symptoms that cannot be alleviated by conventional treatments or neuroablative interventions targeting cortico-striatal loop circuits. Currently, it is unclear how to manage the clinical symptoms of these unique patients. We reasoned that deep brain stimulation (DBS) of the habenula (HB) could be a valuable subsequent treatment option for these otherwise medically intractable cases of severe OCD. The HB is an epithalamic structure critically involved in the encoding and responding to aversive stimulus events, cognitive and brain processes known to be impaired in many patients with OCD. Similarly, HB DBS can alleviate depression and anxiety, which often co-occur with OCD. Here, we explore the clinical benefits and risks of HB DBS treatment in a patient with severe and refractory OCD. CASE PRESENTATION: A 30-year-old male patient presented with persistent and severely disabling OCD symptoms that were refractory to previous psychological and pharmacological treatments as well as to neuroablative surgical interventions involving both capsulotomy and cingulotomy. After HB DBS, however, the severity of the patient's OCD symptoms was markedly reduced at 1-month follow-up, which was sustained until the final (at 12-month) follow-up. The patient also reported enduring improvements in depression, anxiety, and health-related quality of life after several months of HB DBS treatment. CONCLUSIONS: This case report provides the first clinical evidence suggesting that HB DBS could serve as a safe and effective alternative neurosurgical intervention for severe and refractory OCD. The present findings are promising and warrant further research into the role of the HB in pathophysiology and treatment of OCD

Modulation of Attentional Bias to Drug and Affective Cues by Therapeutic and Neuropsychological Factors in Patients With Opioid Use Disorder on Methadone Maintenance Therapy.

Objective: Abnormal selective attention to drug cues and negative affect is observed in patients with substance dependence, and it is closely associated with drug addiction and relapse. Methadone maintenance is an effective replacement therapy to treat heroin addiction, which significantly reduces the relapse rate. The present study examines whether the patients with opioid use disorder on chronic methadone maintenance therapy exhibit abnormal attentional bias to drug cues and negative-affective cues. Moreover, its relation to therapeutic and neuropsychological factors is also examined. Methods: Seventy-nine patients with opioid use disorder under chronic methadone maintenance therapy and 73 age-, sex-, and education-matched healthy controls were recruited and assessed for attentional bias to drug cues and negative affect using a dot-probe detection task. Correlational analysis was used to examine the relationships between the attentional bias and the demographic, therapeutic, and neuropsychological factors. Results: No significant overall patient-control group difference is observed in drug-related or negative-affective-related attentional bias scores. In the patient group, however, a significant negative correlation is found between the attentional bias scores to negative-affective cues and the duration of methadone treatment (p = 0.027), with the patients receiving longer methadone treatment showing less attentional avoidance to negative-affective cues. A significant positive correlation is found between the negative affect-induced bias and the impulsivity score (p = 0.006), with more impulsive patients showing higher attentional avoidance to negative affective cues than less impulsive patients. Additionally, the patients detect a smaller percentage of probe stimuli following the drug (p = 0.029) or negative-affective pictures (p = 0.009) than the healthy controls. Conclusion: The results of the present study indicate that the patients under chronic methadone maintenance therapy show normalized attentional bias to drug and negative-affective cues, confirming the involuntary attention of the patients is not abnormally captured by external drug or negative-affective clues. Our findings also highlight that the attentional avoidance of negative-affective cues is modulated by the duration of methadone treatment and the impulsivity level in the patients

Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy.

BACKGROUND: Obsessive-compulsive disorder (OCD) is a relatively common and disabling psychiatric disorder whose pathophysiology is incompletely understood. In this study, we utilized magnetic resonance spectroscopy (MRS) in an effort to provide a better understanding of the role of brain gamma-aminobutyric acid (GABA) and glutamate in the pathophysiology of OCD. We hypothesized that beyond the separate effects of these neurotransmitter systems, a disruption in the balance between GABA and glutamate could be particularly relevant to OCD. METHODS: We obtained MRS measures of GABA and glutamate concentrations in the anterior cingulate cortex from 23 adult patients with OCD and 20 sex- and age-matched healthy community volunteers. Established clinical rating scales were used to assess the severities of OCD, anxiety, and depression symptoms. Statistical analysis involved the assessment of patient-control group differences in the individual measures of GABA and glutamate, as well as in the ratio of the GABA to glutamate measures. Additionally, we explored whether differences in the MRS measures existed between two subgroups of patients formed according to the severity of their OCD symptoms. Finally, we assessed the relations of demographic and clinical variables to the MRS measures. RESULTS: Patients with OCD displayed a higher estimated GABA level and a higher GABA to glutamate ratio than healthy participants, but no significant group differences were observed in the measure of glutamate. The MRS measures did not vary by subgroup and showed no correlations with demographic and clinical variables. CONCLUSIONS: These results indicate that GABA abnormalities within the anterior cingulate cortex contribute to the pathophysiology of OCD. The results fail to provide evidence that glutamate abnormalities alone are involved in adult OCD. Yet, it seems that a disruption in the balance between glutamate and GABA neurotransmission may have a particularly important role to play in OCD pathophysiology

Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study.

Objectives:Late-life depression (LLD) has negative impacts on somatic, emotional and cognitive domains of the lives of patients. Elucidating the abnormality in the brain networks of LLD patients could help to strengthen the understanding of LLD pathophysiology, however, the studies exploring the spontaneous brain activity in LLD during the resting state remain limited. This study aimed at identifying the voxel-level whole-brain functional connectivity changes in LLD patients. Methods:Fifty patients with late-life depression (LLD) and 33 healthy controls were recruited. All participants underwent a resting-state functional magnetic resonance imaging scan to assess the voxel-wise degree centrality (DC) changes in the patients. Furthermore, DC was compared between two patient subgroups, the late-onset depression (LOD) and the early-onset depression (EOD). Results:Compared with the healthy controls, LLD patients showed increased DC in the inferior parietal lobule, parahippocampal gyrus, brainstem and cerebellum (p < 0.05, AlphaSim-corrected). LLD patients also showed decreased DC in the somatosensory and motor cortices and cerebellum (p < 0.05, AlphaSim-corrected). Compared with EOD patients, LOD patients showed increased centrality in the superior and middle temporal gyrus and decreased centrality in the occipital region (p < 0.05, AlphaSim-corrected). No significant correlation was found between the DC value and the symptom severity or disease duration in the patients after the correction for multiple comparisons. Conclusions:These findings indicate that the intrinsic abnormality of network centrality exists in a wide range of brain areas in LLD patients. LOD patients differ with EOD patients in cortical network centrality. Our study might help to strengthen the understanding of the pathophysiology of LLD and the potential neural substrates underlie related emotional and cognitive impairments observed in the patients

Impulsivity and craving in subjects with opioid use disorder on methadone maintenance treatment.

BACKGROUND: Methadone maintenance treatment (MMT) is effective in decreasing opioid use or facilitating abstinence. Previous studies using small opioid use disorder samples suggest that cognitive impairments including impulsivity and executive functions may partially improve on MMT, but a range of deficits may persist. However, systematic assessments with larger samples are needed to confirm the profile of cognitive functions on MMT. METHODS: We assessed four types of impulsivity (delay discounting, reflection impulsivity, risk taking and motoric impulsivity), executive functioning (spatial working memory, paired associative learning and strategic planning) and drug cue-induced craving in a relatively large population (115 MMT patients, 115 healthy controls). The relationships between impulsivity, drug cue-induced craving and addiction-related variables were also assessed. RESULTS: Delay discounting, as well as drug cue-induced craving was increased in patients, while motoric impulsivity was lower than in controls. Paired associative learning was additionally impaired, which was explained by increased depression and anxiety levels in patients. Within the MMT group, the delay discounting and drug-cue induced craving scores were positively correlated with self-reported urgency, but unrelated to methadone dosage, duration on methadone, withdrawal symptoms, or presence of nicotine dependence. CONCLUSIONS: Our findings highlight increased delay discounting and cue-induced craving in MMT patients suggesting a potential role for trait effects in delay discounting. Although previous smaller studies have shown impaired executive function, in our large sample size on chronic MMT we only observed impaired associative learning related to depressive and anxiety symptoms highlighting a role for managing comorbid symptoms to further optimize cognitive function