Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease

Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronary disease remains unclear. We have investigated whether gene expression patterns in peripheral blood correlate with the severity of coronary disease and whether these patterns correlate with the extent of atherosclerosis in the vascular wall

Mathematical modeling of exercise fatigability in the severe domain: A unifying integrative framework in isokinetic condition

International audienceMuscle fatigue is the decay in the ability of muscles to generate force, and results from neural and metabolic perturbations. This article presents an integrative mathematical model that describes the decrease in maximal force capacity (i.e. fatigue) over exercises performed at intensities above the critical force Fc (i.e. severe domain). The model unifies the previous Critical Power Model and All-Out Model and can be applied to any exercise described by a changing force F over time. The assumptions of the model are (i) isokinetic conditions, an intensity domain of Fc < F, (ii) constant individual parameters of Fc and tau (iii) fatigability proportional to the accumulation of impulse Jac above the critical force Fc. The present study adjusted the parameters to fit previous experimental observations from three types of exercises: constant intensity, all-out, and increasing ramp exercise. This integrative model establishes a connection between the previous individual models and provides an excellent description of exercise fatigability in the severe domain. With this new integrative model, the maximal force production of the muscle can be predicted over time during both maximal and submaximal exercises