1,436 research outputs found

    Epigenetic aspects of pancreatic beta cell function in type 2 diabetes

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    A robust adaptive wavelet-based method for classification of meningioma histology images

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    Intra-class variability in the texture of samples is an important problem in the domain of histological image classification. This issue is inherent to the field due to the high complexity of histology image data. A technique that provides good results in one trial may fail in another when the test and training data are changed and therefore, the technique needs to be adapted for intra-class texture variation. In this paper, we present a novel wavelet based multiresolution analysis approach to meningioma subtype classification in response to the challenge of data variation.We analyze the stability of Adaptive Discriminant Wavelet Packet Transform (ADWPT) and present a solution to the issue of variation in the ADWPT decomposition when texture in data changes. A feature selection approach is proposed that provides high classification accuracy

    Separation of magnetic subfabrics by high-field, lowtemperature torque measurements

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    The anisotropy of magnetic susceptibility (AMS) can serve as a good indicator of strain in deformed carbonate rocks with diamagnetic susceptibility (Owens and Rutter 1978; de Wall 2000). However, the magnetic fabric due to the diamagnetic carbonate minerals is usually very weak and interpretation of the AMS in these rocks is often complicated by the presence of paramagnetic and ferromagnetic phases which overprint the diamagnetic subfabric. For this reason contributions from ferromagnetic and paramagnetic minerals to the AMS should be separated for a reliable interpretation of the AMS. Ferromagnetic contributions to the AMS can be separated by high-field measurements, using a torque magnetometer (Martin- Hernandez and Hirt 2001). The remaining paramagnetic and diamagnetic contributions can be discriminated by their different temperature dependencies. The paramagnetic susceptibility increases as an inverse function of temperature, whereas the diamagnetic part remains constant. Altogether, AMS measurements at high fields and low temperatures allow for the discrimination of all three subfabrics. Test measurements with the high-field torque magnetometer at liquid nitrogen temperature were performed. It is possible to keep the specimens at low temperature over the measurement period using a cryostat. The main problem is the suppression of mechanical disturbances during the measurement so that the sensitivity of the instrument is retained. The torque of paramagnetic minerals increases strongly at low temperature which results in an amplification of the paramagnetic subfabric. The quantitative separation of diamagnetic and paramagnetic subfabric is under investigation. The result is promising when there is a significant diamagnetic signal.conferenc

    Homotopy colimits – comparison lemmas for combinatorial applications

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    Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.We provide a “toolkit” of basic lemmas for the comparison of homotopy types of homotopy colimits of diagrams of spaces over small categories. We show how this toolkit can be used in quite different fields of applications. We demonstrate this with respect to 1. Björner's “Generalized Homotopy Complementation Formula” [5], 2. the topology of toric varieties, 3. the study of homotopy types of arrangements of subspaces, 4. the analysis of homotopy types of subgroup complexes

    Separation of diamagnetic and paramagnetic anisotropy by high-field, low-temperature torque measurements

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    The anisotropy of magnetic susceptibility (AMS) of rocks can be composed of contributions from ferromagnetic, paramagnetic and diamagnetic minerals. However, in general the AMS of only one fraction is of interest. While there are several approaches to isolate the ferromagnetic contribution to the AMS, the separation of the diamagnetic from the paramagnetic contribution is still problematic. A new method for the separation of these two contributions based on high-field torque measurements at room and low-temperature is presented. The paramagnetic anisotropy increases at low temperature according to the Curie-Weiss law, whereas the diamagnetic contribution is temperature independent. If the paramagnetic AMS is due to perfectly oblate or prolate minerals and the ratio of the susceptibility differences at two temperatures is known, paramagnetic and diamagnetic AMS can be separated. When measuring in fields high enough to saturate the ferromagnetic phases all three contributions to the AMS can be separated. The separation of paramagnetic and diamagnetic AMS is demonstrated on natural crystals and synthetic calcite-muscovite aggregates. A high-field torque magnetometer, equipped with a cryostat for measurements at 77 K, allows sensitive measurements at two different temperatures. The sensitivity at 77 K is 3 × 10−7 J and standard-sized (palaeomagnetic) samples of 11.4 cm3 can be measured. This new method is especially suited for the investigation of diamagnetic fabrics of impure carbonate rock

    Midterm Results After Subtrochanteric End-to-Side Valgization Osteotomy in Severe Infantile Coxa Vara

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    Background: For the treatment of the severe infantile coxa vara it is mandatory for the orthopaedic surgeon to observe the mechanobiology of the growing hip before and after the surgical intervention. We hereby would like to present our experiences with the subtrochanteric end-to-side valgization osteotomy and to compare the procedure with the alternatively used Y-shaped osteotomy as described by Pauwels. Methods: Thirteen patients (20 hips) who had undergone subtrochanteric end-to-side valgization were followed for a mean 6.2 years (range, 0.8 to 12.8 y). At the time of surgery the mean age was 7.1 years (range, 2.0 to 13.3 y), last follow-up examination was performed at a mean of 13.4 years of age (range, 5.1 to 18.3 y). The deformities were etiologically based on 5 entities: congenital coxa vara (n = 1), osteochondrodysplasias (n = 12), postosteomyelitic coxa vara (n = 5), and avascular femoral head necrosis in the course of congenital dysplasia of the hip (n = 2). The follow-up rate was 100%. In addition, we analyzed a total of 93 pelvic radiographies with a total of 139 hip joints. Thirty angles and distances were assessed according to parameters described in the literature. Results: Although preoperatively 12 patients presented with a positive Trendelenburg's sign, it was only present postoperatively in 2 patients. Duchenne's limp reduced from 10 to 1. All of the 15 preoperatively apparent nonunions could be healed by means of surgery. Two hips redeveloped pathologically lowered collodiaphyseal angles postoperatively, one of which had to undergo revision surgery. Preoperatively 15 out of 20 patients (75%) showed nonunions all of which healed after surgery. No recurrence could be seen at the time of the last follow-up. The following angles were assessed on plain radiographies of the pelvis preoperatively and directly postoperatively as well as on the last follow-up at a mean of 85 months: CCD-angle 98 degrees/156 degrees/144 degrees, EY-angle 55 degrees/5 degrees/15.7 degrees, AY-angle 32 degrees/75 degrees/66 degrees, CE-angle 20 degrees/25 degrees/18 degrees, AC-angle 20 degrees/18 degrees/20 degrees. The articulotrochanteric distance was 5 mm/26 mm/14 mm. Conclusions: The subtrochanteric end-to-side valgization osteotomy showed to be highly effective in the management of the infantile coxa vara, improving the clinical impairment of the patients postoperatively. All of the preoperatively present nonunions showed osseous consolidation at follow-up examination. Only minor revarization tendencies could be found. The procedure is technically less demanding, safer and more efficient regarding the lengthening of the affected limb in comparison to the Y-shaped intertrochanteric osteotomy as described by Pauwels. Level of Evidence: Case-control study (EBM-level III)

    Towards an Appropriation Infrastructure: Supporting User Creativity in IT Adoption

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    Research on the adoption of information systems (IS) often stated technology as a fixed entity. Following the ’practical turn’ in IS we argue that information technology artefacts are mainly ’cultural artefacts’, which are shaped in a social process of appropriation where software usage is accompanied by processes of interpretation, negotiation or change in organizations. We elaborate on a (neo-)Marxian interpretation of appropriation from a design-oriented perspective in order to investigate the possibilities of technological support of activities of appropriation work. To capture the different facets of appropriation, we combine theoretical concepts of social capital and activity-based learning. With the help of this theoretical orientation, we systemize empirical evidence from several research projects in order to detect recurring patterns. We use these patterns to develop a generic architecture for actively supporting the social activity of appropriating the cultural artefact in context of its usage

    Correlation of magnetic fabric and crystallographic preferred orientations of naturally deformed carbonate — mica rocks from the Alpi Apuane in Italy and the Damara Orogen in Namibia

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    The anisotropy of magnetic susceptibility (AMS) is a time-efficient method to describe crystallographic preferred orientations of rocks and has been applied in a wide field of sedimentary, metamorphic and magmatic geology. The method, however, suffers from limitations which mainly result from the interference of diamagnetic, paramagnetic and ferromagnetic fabrics (de Wall 2005) — the term ferromagnetism is used in a wider sense here, including e.g. ferrimagnetism. The AMS is an integral parameter which describes a crystallographic preferred orientation as an ellipsoid. The quantitative correlation of the AMS with the crystallographic preferred orientations should help to allow a closer view at the applicability and the limitations of the AMS analysis (see also Schmidt et al. 2006 a, b)... The results of this study are based on a large variety of fabric types of carbonate-mica marbles and mylonites, i.e. varying mica content, grain sizes, grain shapes, types and intensities of the crystallographic preferred orientation. The presented first correlations of the AMS and CPO for the single mineral phases in general demonstrate a good matching. Regarding the comparison of texture types and the AMS, limitations are possible. While single c-axis maxima and girdle-like c-axis distributions can be also distinguished by the AMS, it is obvious that distinguishing between these types and the double c-axis type is not possible at the present stage.conferenc

    The economics of potato crop rotations in southern Manitoba

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    Non-Peer ReviewedRapid expansion of the potato industry in Manitoba has led to increased potato production in Manitoba. While the introduction of potatoes into current cropping systems may provide an opportunity for producers to increase the profitability of their farming operation, development of economically and environmentally sustainable production systems is key to the long-term success of the industry. Currently, little information is available about the economic and environmental impacts of such crop rotations with respect to potato production in Canada. Recognizing the importance of sustainable production systems, in 1998, a potato crop rotation study was established at Manitoba Crop Diversification Center (MCDC) at Carberry to develop recommendations for irrigated potato management in southern Manitoba. Six crop rotations ranging from two to four years in duration, and containing potatoes in combination with oilseed, cereal and/or legume crops, were included in this study. Each phase of each rotation was present in each year making a total of 18 treatments. This paper discusses the economic return of these six different crop rotations. The data with respect to all the production practices, including storage, transport and marketing for the period of 1998 to 2001 were collected and analyzed using a computer model developed for this purpose. Econometrics View software was used to develop this model, and the model takes into account the whole system for each rotation when analyzing the data. The preliminary results suggest that, for the period of 1999 through 2000, both potato-canola and potato-oat-wheat rotations appeared to be promising rotations. However, the poor potato yield of the potato-oatwheat rotation in 2001 resulted in low average net income for that rotation. The higher net benefit of the potato-canola rotation during the time period analyzed was primarily the result of a higher proportion of the tuber yield being of marketable size, not for higher gross tuber or canola yields. It is, however, difficult to make firm conclusions at this point of time as to which rotation will be most profitable in the long term. This is mainly because of the rotation treatments have only been in place since 1998 and, as such, observed differences among rotations may be a function not only of the rotation but also of environmental conditions and management within a given year

    Measurement of calcite crystallographic-preferred orientations by magnetic anisotropy and comparison to diffraction methods

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    The anisotropy of magnetic susceptibility (AMS) of rocks reflects the preferred orientations of minerals. Therefore AMS is a quick and easy way to characterize rock fabrics (Hrouda 1982,Borradaile 1988); the obtained result is also called the magnetic fabric of the rock. The method has been often used to measure the orientation of ferromagnetic minerals, mainly magnetite, but in recent studies it has been increasingly used to measure textures of paramagnetic minerals as phyllosilicates (Lüneburg et al. 1999, Cifelli et al. 2004). A further application is the measurement of diamagnetic textures, especially calcite textures. Calcite is suitable for the AMS method, because it has a high magnetic anisotropy with the minimum susceptibility along the crystallographic c-axis. Therefore a preferred orientation of the c-axes, which can be induced by deformation, generates a magnetic fabric...conferenc
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