3,421 research outputs found

    Assessment into the usage of levetiracetam in a canine epilepsy clinic

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    Gamma Rays from Clusters and Groups of Galaxies: Cosmic Rays versus Dark Matter

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    Clusters of galaxies have not yet been detected at gamma-ray frequencies; however, the recently launched Fermi Gamma-ray Space Telescope, formerly known as GLAST, could provide the first detections in the near future. Clusters are expected to emit gamma rays as a result of (1) a population of high-energy primary and re-accelerated secondary cosmic rays (CR) fueled by structure formation and merger shocks, active galactic nuclei and supernovae, and (2) particle dark matter (DM) annihilation. In this paper, we ask the question of whether the Fermi telescope will be able to discriminate between the two emission processes. We present data-driven predictions for a large X-ray flux limited sample of galaxy clusters and groups. We point out that the gamma ray signals from CR and DM can be comparable. In particular, we find that poor clusters and groups are the systems predicted to have the highest DM to CR emission at gamma-ray energies. Based on detailed Fermi simulations, we study observational handles that might enable us to distinguish the two emission mechanisms, including the gamma-ray spectra, the spatial distribution of the signal and the associated multi-wavelength emissions. We also propose optimal hardness ratios, which will help to understand the nature of the gamma-ray emission. Our study indicates that gamma rays from DM annihilation with a high particle mass can be distinguished from a CR spectrum even for fairly faint sources. Discriminating a CR spectrum from a light DM particle will be instead much more difficult, and will require long observations and/or a bright source. While the gamma-ray emission from our simulated clusters is extended, determining the spatial distribution with Fermi will be a challenging task requiring an optimal control of the backgrounds.Comment: revised to match resubmitted version, 35 pages, 16 figures: results unchanged, some discussion added and unnecessary text and figures remove

    Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs

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    It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous adiponectin secreted by adipocytes is post-translationally modified into eight different isoforms, as shown by two-dimensional gel electrophoresis. Carbohydrate detection revealed that six of the adiponectin isoforms are glycosylated. The glycosylation sites were mapped to several lysines (residues 68, 71, 80, and 104) located in the collagenous domain of adiponectin, each having the surrounding motif of GXKGE(D). These four lysines were found to be hydroxylated and subsequently glycosylated. The glycosides attached to each of these four hydroxylated lysines are possibly glucosylgalactosyl groups. Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines. These results indicate that full-length adiponectin produced by mammalian cells is functionally active as an insulin sensitizer and that hydroxylation and glycosylation of the four lysines in the collagenous domain might contribute to this activity.link_to_subscribed_fulltex

    Spectrum of cosmic rays, produced in supernova remnants

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    Nonlinear kinetic theory of cosmic ray (CR) acceleration in supernova remnants is employed to calculate CR spectra. The magnetic field in SNRs is assumed to be significantly amplified by the efficiently accelerating nuclear CR component. It is shown that the calculated CR spectra agree in a satisfactory way with the existing measurements up to the energy 101710^{17} eV. The power law spectrum of protons extends up to the energy 3×10153\times 10^{15} eV with a subsequent exponential cutoff. It gives a natural explanation for the observed knee in the Galactic CR spectrum. The maximum energy of the accelerated nuclei is proportional to their charge number ZZ. Therefore the break in the Galactic CR spectrum is the result of the contribution of progressively heavier species in the overall CR spectrum so that at 101710^{17} eV the CR spectrum is dominated by iron group nuclei. It is shown that this component plus a suitably chosen extragalactic CR component can give a consistent description for the entire Galactic CR spectrum.Comment: 4 pages with emulateapj, 3 figures, accepted for publication in the Astrophysical Journal Letter

    Dorsal laminectomy for treatment of cervical vertebral stenotic myelopathy in an alpaca

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    Comparison of building thermography approaches using terrestrial and aerial thermographic images

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    Thermography is commonly used for auditing buildings. Classical manual terrestrial thermography records images of individual buildings at a short distance. When auditing a large number of buildings (e.g. whole city districts) this approach reaches its limits. Using drones with thermographic cameras allows images to be recorded automatically from different angles, with faster speed and without violating property rights. However, an airborne camera has a significantly greater distance and more varied angles to a building compared to terrestrial thermography. To investigate the influence of these factors for building auditing, we perform a study evaluating seven different drone settings of varying flight speed, angle, and altitude. A comparison is drawn to manually recorded terrestrial thermographic images. While we find that a flight speed between 1m/s and 3m/s does not influence the thermographic quality, high flight altitudes and steep viewing angles lead to a significant reduction of visible details, contrast, and to falsified temperatures. A flight altitude of 12m over buildings is found to be the most suitable for the qualitative and quantitative analysis of rooftops and a qualitative analysis of façades. A flight altitude of 42m over buildings can only be used for qualitative audits with little detail

    Galactic Gamma-Ray Background Radiation from Supernova Remnants

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    The contribution of the Source Cosmic Rays (SCRs), confined in Supernova Remnants, to the diffuse high energy \gr emission above 1 GeV from the Galactic disk is studied. \grs produced by the SCRs have a much harder spectrum compared with those generated by the Galactic Cosmic Rays which occupy a much larger residence volume uniformly. SCRs contribute less than 10% at GeV energies and become dominant at \gr energies above 100 GeV. The contributions from π0\pi^0-decay and Inverse Compton \grs have comparable magnitude and spectral shape, whereas the Bremsstrahlung component is negligible. At TeV energies the contribution from SCRs increases the expected diffuse \gr flux almost by an order of magnitude. It is shown that for the inner Galaxy the discrepancy between the observed diffuse intensity and previous model predictions at energies above a few GeV can be attributed to the SCR contribution.Comment: 25 pages, 1 figures, to appear in Ap
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