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The disruption of proteostasis in neurodegenerative diseases

Author: Abravaya K Phillips B, Morimoto RI
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Publication venue: 'American Institute of Mathematical Sciences (AIMS)'
Publication date: 01/01/2015
Field of study

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

Universidade do Minho: RepositoriUM

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Pseudothermoosmosis in a Composite Membrane System

Author: Aubert M
L D’Ilario
Lippmann G
Liquori A. M
M Canella
Riehl N
Voellmy von H
Publication venue: 'Society of Polymer Science, Japan'
Publication date: 01/01/1977
Field of study

The pseudothermoosmotic pressure of a composite membrane system, constituted by 2 cellulose (I) [9004-34-6] membranes and an aq. polyethylene glycol [25322-68-3], approached ∼6.0 × 105 dyn cm-2 which was higher than that measured with simple I membranes. The thermodn. of irreversible processes was used to derive the composite membrane phenomenol. equations contg. both the classical thermoosmosis and the thermal diffusion. A value of 3.91 kcal mol-1 was calcd. for the apparent activation energy, indicating the diffusive nature of the solvent flow through the composite membrane

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