5 research outputs found
The Death of God in the Philosophy of Friedrich Nietszche
Katedra občanské výchovy a filosofieFaculty of EducationPedagogická fakult
Spray drying of drug suspension in lactose solution
Charles University, Faculty of Pharmacy in Hradec KrálovĂ© Department of: Pharmaceutical Technology Consultant: PharmDr. Petra SvaÄŤinová, Ph.D. Student: Klára Vlková Title of Thesis: Spray drying of a drug suspension in lactose solution Spray drying can be used to increase the solubility and thus bioavailability of drugs that are poorly soluble in water. In the present work, particles from a suspension of meloxicam in lactose solution were prepared by spray drying. The effect of the nozzle size of 0.7 mm and 1.4 mm, the effect of drug concentration of 0.5 g/100 ml and 1 g/100 ml, and the effect of lactose concentration on the properties of the resulting particles were investigated. The lactose solutions used had concentrations of 15, 20 and 25 %. The appearance and size of the formed particles were evaluated using optical and scanning electron microscopy (SEM). The amount of drug released was investigated using dissolution and the thermal characteristics of the particles were evaluated using differential scanning calorimetry (DSC). The evaluation by SEM and DSC was then performed again 6 months after the first measurement. The resulting particles were spherical in shape with no surface irregularities. Some of them contained clusters of meloxicam particles. At the second observation after 6 months,...Univerzita Karlova, FarmaceutickĂ© fakulta v Hradci KrálovĂ© Katedra: Farmaceutická technologie Ĺ kolitel: PharmDr. Petra SvaÄŤinová, Ph.D PosluchaÄŤ: Klára Vlková Název diplomovĂ© práce: SprejovĂ© sušenĂ suspenze lĂ©ÄŤiva v roztoku laktĂłzy SprejovĂ© sušenĂ mĹŻĹľe bĂ˝t vyuĹľĂváno pro zvýšenĂ rozpustnosti a tĂm biologickĂ© dostupnosti lĂ©ÄŤiv, kterĂ© jsou špatnÄ› rozpustná ve vodÄ›. V tĂ©to práci byly sprejovĂ˝m sušenĂm pĹ™ipravenĂ© částice ze suspenze meloxikamu v roztoku laktĂłzy. Byl zkoumán vliv velikosti trysky 0,7 mm a 1,4 mm, vliv koncentrace lĂ©ÄŤiva 0,5 g /100 ml a 1 g/100 ml, a takĂ© vliv koncentrace laktĂłzy na vlastnosti vzniklĂ˝ch částic. PouĹľitĂ© roztoky laktĂłzy mÄ›ly koncentrace 15, 20 a 25 %. HodnocenĂ vzhledu a velikosti vzniklĂ˝ch částic bylo provedeno s pomocĂ optickĂ© a skenovacĂ elektronovĂ© mikroskopie (SEM). Za vyuĹľitĂ disoluce bylo zkoumáno mnoĹľstvĂ uvolnÄ›nĂ©ho lĂ©ÄŤiva a tepelnĂ© charakteristiky částic byly hodnoceny pomocĂ diferenciálnĂ skenovacĂ kalorimetrie (DSC). HodnocenĂ pomocĂ SEM a DSC bylo potĂ© provedeno znovu po 6 mÄ›sĂcĂch od prvnĂho měřenĂ. VzniklĂ© částice byly kulovitĂ©ho tvaru bez povrchovĂ˝ch nerovnostĂ. V nÄ›kterĂ˝ch z nich se nacházely shluky částic meloxikamu. PĹ™i druhĂ©m pozorovánĂ po 6 mÄ›sĂcĂch byla patrná krystalizace sfĂ©rickĂ˝ch částic amorfnĂ laktĂłzy. VelikostnĂ rozmezĂ vÄ›tšiny částic se...Department of Pharmaceutical TechnologyKatedra farmaceutickĂ© technologieFarmaceutická fakulta v Hradci KrálovĂ©Faculty of Pharmacy in Hradec Králov
The Death of God in the Philosophy of Friedrich Nietszche
Katedra občanské výchovy a filosofieFaculty of EducationPedagogická fakult
Spray drying of drug suspension in lactose solution
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Klára Vlková Title of Thesis: Spray drying of a drug suspension in lactose solution Spray drying can be used to increase the solubility and thus bioavailability of drugs that are poorly soluble in water. In the present work, particles from a suspension of meloxicam in lactose solution were prepared by spray drying. The effect of the nozzle size of 0.7 mm and 1.4 mm, the effect of drug concentration of 0.5 g/100 ml and 1 g/100 ml, and the effect of lactose concentration on the properties of the resulting particles were investigated. The lactose solutions used had concentrations of 15, 20 and 25 %. The appearance and size of the formed particles were evaluated using optical and scanning electron microscopy (SEM). The amount of drug released was investigated using dissolution and the thermal characteristics of the particles were evaluated using differential scanning calorimetry (DSC). The evaluation by SEM and DSC was then performed again 6 months after the first measurement. The resulting particles were spherical in shape with no surface irregularities. Some of them contained clusters of meloxicam particles. At the second observation after 6 months,..
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