63 research outputs found
Congreso Eucarístico Nacional
Del 17 al 23 de junio se celebró en Sevilla el séptimo Congreso Eucarístico Nacional de España y el primero después del Concilio Vaticano II. La siguiente nota señala los principales momentos y contenidos de dicha celebración
Incidencia de la mutación V617F de JAK2 en una serie de 350 pacientes con síndromes mieloproliferativos crónicos BCR-ABL negativos clásicos
Methylation status of SOCS1 and SOCS3 in BCR-ABL negative and JAK2V617F negative chronic myeloproliferative neoplasms
NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2
The t(7;11)(p15;p15.4) has been reported to fuse the NUP98 gene (11p15), a component of the nuclear pore complex, with the class-1 homeobox gene HOXA9 at 7p15. This translocation has been associated with myeloid leukemias, predominantly acute myeloid leukemia (AML) M2 subtype with trilineage myelodysplastic features, and with a poor prognosis. The derived fusion protein retains the FG repeat motif of NUP98 N-terminus and the homeodomain shared by the HOX genes, acting as an oncogenic transcription factor critical for leukemogenesis. We report here a new complex t(7;11)-variant, i.e., t(7;11;13;17)(p15;p15;p?;p1?2) in a patient with AML-M2 and poor prognosis. The NUP98-HOXA9 fusion transcript was detected by RT-PCR, suggesting its role in the malignant transformation as it has been postulated for other t(7;11)-associated leukemias. No other fusion transcripts involving the NUP98 or HOXA9 genes were present, although other mechanisms involving several genes on chromosomes 13 and 17 may also be involved. To our knowledge, this is the first t(7;11) variant involving NUP98 described in hematological malignancies
Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
Lactation undernutrition leads to multigenerational molecular programming of hypothalamic gene networks controlling reproduction
The Lean Mass Predicts Changes In Bone Mineral Content In Women Of Reproductive Age Regardless Of Cardiorespiratory Physical Fitness Levels
The Lean Mass Predicts Changes In Bone Mineral Content In Women Of Reproductive Age Regardless Of Cardiorespiratory Physical Fitness Levels
Etat nutritionnel, composition corporelle et habitudes alimentaires « mondialisées » des adolescents
International audienc
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