Aldose Reductase Inhibition or Activation of Transketolase Offset Adverse Metabolic Remodeling Improving Function in Type 2 Diabetes Myocytes Exposed to Hyperglycemia

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Palmitate Improves Basal and β-Stimulated Left Ventricle Function in Diabetic Mouse Hearts

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Anthropometric profile and cardiovascular parameters of participants of a program of promotion of health of Araranguá/SC

This study aimed to investigate the anthropometric and cardiovascular profile of participants in a health promotion program in the city of Araranguá (Santa Catarina, Brazil), as well as, their levels of physical activity. A cross-sectional study was carried out from July to December of 2015. Data collection was performed within 323 individuals aged between 18 and 90 years, and a high prevalence of overweight and obesity (70.5%) and Hypertension (43.3%) was observed. The risk factors converge to the most prevalent in the population, being overweight and hypertensive. This survey helps in the definition of new promotion and prevention programs, besides strengthening the health strategies of the municipality

Perfil antropométrico e parâmetros cardiovasculares dos participantes de um programa de promoção da saúde de Araranguá/SC

This study aimed to investigate the anthropometric and cardiovascular profile of participants in a health promotion program in the city of Araranguá (Santa Catarina, Brazil), as well as, their levels of physical activity. A cross-sectional study was carried out from July to December of 2015. Data collection was performed within 323 individuals aged between 18 and 90 years, and a high prevalence of overweight and obesity (70.5%) and Hypertension (43.3%) was observed. The risk factors converge to the most prevalent in the population, being overweight and hypertensive. This survey helps in the definition of new promotion and prevention programs, besides strengthening the health strategies of the municipality.Este estudo buscou investigar os parâmetros antropométricos e cardiovasculares de participantes de um programa de extensão em promoção da saúde na cidade de Araranguá (Santa Catarina, Brasil), bem como seus níveis de atividade física. Foi realizado um estudo transversal no período de julho a dezembro de 2015. A coleta dos dados foi realizada com 323 indivíduos com idade entre 18 a 90 anos, e observou-se alta prevalência de sobrepeso e obesidade (70,5%) e hipertensão autorreferida (43,3%). Os fatores de risco encontrados convergem para os mais prevalentes na população, excesso de peso e hipertensão. Este levantamento auxilia na definição de novos programas de promoção e prevenção além de fortalecer as estratégias de saúde do municípioEste estudio tuvo como objetivo investigar los parámetros antropométricos y cardiovasculares de los participantes en un programa de promoción de la salud en la ciudad de Araranguá, así como sus niveles de actividad física. Un estudio de la sección transversal en el periodo de julio a diciembre de 2015. La recogida de datos se realizó con 323 sujetos de edad 18- 90 años y se observó una alta prevalencia del sobrepeso y la obesidad (70,5%) y dicho hipertensión auto (43,3%). Los factores de riesgo encontraron a converger el más prevalentes en la población, el sobrepeso y la hipertensión. Esta encuesta ayuda en la definición de nuevos programas de promoción y prevención, así como el fortalecimiento de las estrategias de salud del municipi

Metabolic remodeling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice

Hearts from type 2 diabetic animals display perturbations in excitation-contraction coupling, impairing myocyte contractility and delaying relaxation, along with altered substrate consumption patterns. Under high glucose and β-adrenergic stimulation conditions, palmitate can, at least in part, offset left ventricle (LV) dysfunction in hearts from diabetic mice improving contractility and relaxation while restoring coronary perfusion pressure. Fluxome calculations of central catabolism in diabetic hearts show that, in presence of palmitate, there is a metabolic remodeling involving tricarboxylic acid cycle, polyol and pentose phosphate pathways, leading to improved redox balance in cytoplasmic and mitochondrial compartments. Under high glucose and increased energy demand, the metabolic/fluxomic re-direction leading to restored redox balance imparted by palmitate helps explain maintained LV function and may contribute to design novel therapeutic approaches to prevent cardiac dysfunction in diabetic patients