18 research outputs found
Use of Site-Directed Mutagenesis To Identify Residues Specific for Each Reaction Catalyzed by Chorismate Mutase−Prephenate Dehydrogenase from Escherichia coli
Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7
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Snowmass2021 - Letter of interest cosmology intertwined II: The hubble constant tension
The current cosmological probes have provided a fantastic confirmation of the standard Cold Dark Matter cosmological model, which has been constrained with unprecedented accuracy. However, with the increase of the experimental sensitivity, a few statistically significant tensions between different independent cosmological datasets emerged. While these tensions can be in part the result of systematic errors, the persistence after several years of accurate analysis strongly hints at cracks in the standard cosmological scenario and the need for new physics. In this Letter of Interest we will focus on the tension between the Planck estimate of the Hubble constant and the SH0ES collaboration measurements. After showing the evaluations made from different teams using different methods and geometric calibrations, we will list a few interesting models of new physics that could solve this tension and discuss how the next decade’s experiments will be crucial
Snowmass2021 - Letter of interest cosmology intertwined I: Perspectives for the next decade
International audienceThe standard Λ Cold Dark Matter cosmological model provides an amazing description of a wide range of astrophysical and astronomical data. However, there are a few big open questions, that make the standard model look like a first-order approximation to a more realistic scenario that still needs to be fully understood. In this Letter of Interest we will list a few important goals that need to be addressed in the next decade, also taking into account the current discordances present between the different cosmological probes, as the Hubble constant H0 value, the σ8S8 tension, and the anomalies present in the Planck results. Finally, we will give an overview of upgraded experiments and next-generation space-missions and facilities on Earth that will be of crucial importance to address all these questions
Snowmass2021 - Letter of interest cosmology intertwined IV: The age of the universe and its curvature
International audienceA precise measurement of the curvature of the Universe is of prime importance for cosmology since it could not only confirm the paradigm of primordial inflation but also help in discriminating between different early-Universe scenarios. Recent observations, while broadly consistent with a spatially flat standard Λ Cold Dark Matter ( Λ CDM) model, show tensions that still allow (and, in some cases, even suggest) a few percent deviations from a flat universe. In particular, the Planck Cosmic Microwave Background power spectra, assuming the nominal likelihood, prefer a closed universe at more than 99% confidence level. While new physics could be at play, this anomaly may be the result of an unresolved systematic error or just a statistical fluctuation. However, since positive curvature allows a larger age of the Universe, an accurate determination of the age of the oldest objects provides a smoking gun in confirming or falsifying the current flat Λ CDM model
Snowmass2021 - Letter of interest cosmology intertwined II: The hubble constant tension
International audienceThe current cosmological probes have provided a fantastic confirmation of the standard Λ Cold Dark Matter cosmological model, which has been constrained with unprecedented accuracy. However, with the increase of the experimental sensitivity, a few statistically significant tensions between different independent cosmological datasets emerged. While these tensions can be in part the result of systematic errors, the persistence after several years of accurate analysis strongly hints at cracks in the standard cosmological scenario and the need for new physics. In this Letter of Interest we will focus on the 4.4σ tension between the Planck estimate of the Hubble constant H0 and the SH0ES collaboration measurements. After showing the H0 evaluations made from different teams using different methods and geometric calibrations, we will list a few interesting models of new physics that could solve this tension and discuss how the next decade’s experiments will be crucial
Cosmology intertwined III: and
International audienceThe standard Cold Dark Matter cosmological model provides a wonderful fit to current cosmological data, but a few statistically significant tensions and anomalies were found in the latest data analyses. While these anomalies could be due to the presence of systematic errors in the experiments, they could also indicate the need for new physics beyond the standard model. In this Letter of Interest we focus on the tension between Planck data and weak lensing measurements and redshift surveys, in the value of the matter energy density and the amplitude (or the growth rate ) of cosmic structure. We list a few promising models for solving this tension, and discuss the importance of trying to fit multiple cosmological datasets with complete physical models, rather than fitting individual datasets with a few handpicked theoretical parameters