Primary and secondary prevention of human papillomavirus-associated cancer: it's not all about women

To date, we have two important weapons in the prevention of uterine cervical cancer: vaccine program and organized screening. The most important task for the prevention of cervical cancer is to accelerate an integrated approach of vaccination and screenin

Cervical cancer screening based on human papilloma virus-DNA testing: a scientific heritage to microbiologists or to pathologists? An on-going dilemma

Among the 28 current Members of the European Union, approximately 34,000 new cases of cervical cancer occur annually, with 13,000 related deaths. In Italy, about 2900 cases of cervical cancer are diagnosed annually (crude incidence rate/100,000/year=9.4). As a direct consequence, about 1016 deaths related to cervical cancer are reported annually in Italy (crude mortality rate/100,000/year=3.3). Cervical cancer stands in the 15th rank among female cancers and is currently the 3rd most common cancer in women aged 15-44 years in Italy. [..

Molecular techniques for the detection of the antimicrobial sensitivity: friend or foe?

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How Can the Microbiologist Help in Diagnosing Neonatal Sepsis?

Neonatal sepsis can be classified into two subtypes depending upon whether the onset of symptoms is before 72 hours of life (early-onset neonatal sepsis—EONS) or later (late-onset neonatal sepsis—LONS). These definitions have contributed greatly to diagnosis and treatment by identifying which microorganisms are likely to be responsible for sepsis during these periods and the expected outcomes of infection. This paper focuses on the tools that microbiologist can offer to diagnose and eventually prevent neonatal sepsis. Here, we discuss the advantages and limitation of the blood culture, the actual gold standard for sepsis diagnosis. In addition, we examine the utility of molecular techniques in the diagnosis and management of neonatal sepsis

Molecular methods: are their results of help or do they make more confuse the clinical management of patients?

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Antimicrobial resistance global emergence: healthcare facilities or environmental microbiota as the most important reservoir of antibiotic resistant microorganisms?

The ecosystems contamination caused by drugs and by their biologically active transformation products has become an emerging environmental issue: recently developed analytical and sensitive methods have allowed the detection of these pollutants in different matrices (like water, soil, sediment). [...

Search for serological markers of infection in transfused patients: are the limitations of these assays always clear?

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Global epidemiology of Zika and Chikungunya virus human infections

Zika virus was discovered in 1947. The first reported case of Zika fever was in a sentinel rhesus monkey in Uganda in 1947, while the first human cases were reported in Nigeria in 1954. Since the first evidence of human infection, Zika was active in several countries in Africa and Asia, as sporadic cases and serological evidence of Zika human infections have been demonstrated in several reports. The outbreak of Zika in Yap Island in 2007 is considered the first emergency of this infection. Since then Zika has spread worldwide with a large ongoing epidemic in South and Central America. A huge concern nowadays is about the relationship between Zika infection and microcephaly and about the sexual transmission of the virus. The first identified outbreak of Chikungunya human infection, with an incidence estimated at 23%, was reported from July 1952 to March 1953 in the Southern Province of the current Tanzania. Since then Chikungunya circulated mainly in continental Africa with limited outbreaks. The virus started to spread east bound involving most of the areas surroundings the Indian Ocean. In 2004/2005 a large outbreak developed in La Reunion a French territory in the Indian Ocean: from this point Chikungunya spread to India and from there, due a viraemic traveller returning from Kerala, to Italy where in the summer of 2007 the first outbreak with local viral transmission in a temperate climate zone occurred. In the following years Chikungunya moved to the Caribbean and South America. Recently also the USA experienced the spread of this virus and a limited outbreak based again on local spreading occurred in the French Department of Var, in August 2017

Dengue and falciparum malaria co-infection in travelers returning from Burkina Faso: Report of two cases in Northeastern Italy

Rationale: Malaria and dengue are the most prevalent vector-borne diseases in tropical countries. Plasmodium parasite and dengue virus (DENV) concurrent infection is possible and often under-recognized in geographical areas where these infections are both endemic. Patients concern and diagnosis: We describe the first two cases of Plasmodium falciparum and DENV-3 co-infection in travelers returning to northeastern Italy from Burkina Faso during 2013-2014. Interventions: Malaria infection in both patients was treated with mefloquine. Due to the persistence of symptoms despite of the antimalaria treatment, dengue was also investigated; the treatment of dengue was symptomatic. Outcomes: The patients were discharged in good general condition. Lessons: The need for surveillance of potential malaria and dengue co-infection in travelers returning to Europe from endemic areas is highlighted, as infection with Plasmodium does not exclude arboviral co-infection

Valutazione di un metodo rapido per la diagnosi d'infezione da H. pylori attraverso ricerca di antigene fecale

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