Comparing signal intensity and refraction sensitivity of double and single mask edge illumination lab-based x-ray phase contrast imaging set-ups

Double mask edge illumination (DM-EI) set-ups can detect differential phase and attenuation information from a sample. However, analytical separation of the two signals often requires acquiring two frames with inverted differential phase contrast signals. Typically, between these two acquisitions, the first mask is moved to create a different illumination condition. This can lead to potential errors which adversely affect the data collected. In this paper, we implement a single mask EI laboratory set-up that allows for a single shot retrieval of the differential phase and attenuation images, without the need for a high resolution detector or high magnification. As well as simplifying mask alignment, the advantages of the proposed set-up can be exploited in one of two ways: either the total acquisition time can be halved with respect to the DM-EI set-up or, for the same acquisition time, twice the statistics can be collected. In this latter configuration, the signal-to-noise ratio and contrast in the mixed intensity images, and the angular sensitivity of the two set-ups were compared. We also show that the angular sensitivity of the single mask set-up can be well approximated from its illumination curve, which has been modelled as a convolution between the source spatial distribution at the detector plane, the pre-sample mask and the detector point spread function (PSF). A polychromatic wave optics simulation was developed on these bases and benchmarked against experimental data. It can also be used to predict the angular sensitivity and contrast of any set-up as a function of detector PSF

Relationship between Mediterranean diet and asymptomatic peripheral arterial disease in a population of pre-menopausal women

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Social fluidity mobilizes contagion in human and animal populations

International audienceHumans and other group-living animals tend to distribute their social effort disproportionately. Individuals predominantly interact with a small number of close companions while maintaining weaker social bonds with less familiar group members. By incorporating this behavior into a mathematical model, we find that a single parameter, which we refer to as social fluidity, controls the rate of social mixing within the group. Large values of social fluidity correspond to gregarious behavior, whereas small values signify the existence of persistent bonds between individuals. We compare the social fluidity of 13 species by applying the model to empirical human and animal social interaction data. To investigate how social behavior influences the likelihood of an epidemic outbreak, we derive an analytical expression of the relationship between social fluidity and the basic reproductive number of an infectious disease. For species that form more stable social bonds, the model describes frequency-dependent transmission that is sensitive to changes in social fluidity. As social fluidity increases, animal-disease systems become increasingly density-dependent. Finally, we demonstrate that social fluidity is a stronger predictor of disease outcomes than both group size and connectivity, and it provides an integrated framework for both density-dependent and frequency-dependent transmission

The early evolution of Globular Clusters: the case of NGC 2808

Enhancement and spread of helium among globular cluster stars have been recently suggested as a way to explain the horizontal branch blue tails, in those clusters which show a primordial spread in the abundances of CNO and other elements involved in advanced CNO burning (D'Antona et al. 2002). In this paper we examine the implications of the hypothesis that, in many globular clusters, stars were born in two separate events: an initial burst (first generation), which gives origin to probably all high and intermediate mass stars and to a fraction of the cluster stars observed today, and a second, prolonged star formation phase (second generation) in which stars form directly from the ejecta of the intermediate mass stars of the first generation. In particular, we consider in detail the morphology of the horizontal branch in NGC 2808 and argue that it unveils the early cluster evolution, from the birth of the first star generation to the end of the second phase of star formation. This framework provides a feasible interpretation for the still unexplained dichotomy of NGC 2808 horizontal branch, attributing the lack of stars in the RR Lyr region to the gap in the helium content between the red clump, whose stars are considered to belong to the first stellar generation and have primordial helium, and the blue side of the horizontal branch, whose minimum helium content reflects the helium abundance in the smallest mass (~4Msun)contributing to the second stellar generation. This scenario provides constraints on the required Initial Mass Function, in a way that a great deal of remnant neutron stars and stellar mass black holes might have been produced.Comment: 23 pages, 7 figures, in press on The Astrophysical Journa

Laboratory implementation of edge illumination X-ray phase-contrast imaging with energy-resolved detectors

Edge illumination (EI) X-ray phase-contrast imaging (XPCI) has potential for applications in different fields of research, including materials science, non-destructive industrial testing, small-animal imaging, and medical imaging. One of its main advantages is the compatibility with laboratory equipment, in particular with conventional non-microfocal sources, which makes its exploitation in normal research laboratories possible. In this work, we demonstrate that the signal in laboratory implementations of EI can be correctly described with the use of the simplified geometrical optics. Besides enabling the derivation of simple expressions for the sensitivity and spatial resolution of a given EI setup, this model also highlights the EI’s achromaticity. With the aim of improving image quality, as well as to take advantage of the fact that all energies in the spectrum contribute to the image contrast, we carried out EI acquisitions using a photon-counting energy-resolved detector. The obtained results demonstrate that this approach has great potential for future laboratory implementations of EI. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

Recent advances in edge illumination x-ray phase-contrast tomography

Edge illumination (EI) is an X-ray phase contrast imaging technique, exploiting sensitivity to X-ray refraction in order to visualize features which are often not detected by conventional, absorption-based radiography. The method does not require a high degree of spatial coherence and is achromatic, and can therefore be implemented with both synchrotron radiation and commercial X-ray tubes. Using different retrieval algorithms, information about an object’s attenuation, refraction and scattering properties can be obtained. In recent years, a theoretical framework has been developed that enables EI computed tomography (CT), and hence three dimensional imaging. This review provides a summary of these advances, covering the development of different image acquisition schemes, retrieval approaches and applications. These developments constitute an integral part in the transformation of EI CT into a widely spread imaging tool, for use in a range of fields

A combinatorial model of malware diffusion via Bluetooth connections

We outline here the mathematical expression of a diffusion model for cellphones malware transmitted through Bluetooth channels. In particular, we provide the deterministic formula underlying the proposed infection model, in its equivalent recursive (simple but computationally heavy) and closed form (more complex but efficiently computable) expression.Comment: In press on PlosON

Robust phase retrieval for high resolution edge illumination x-ray phase-contrast computed tomography in non-ideal environments

Edge illumination x-ray phase contrast tomography is a recently developed imaging technique which enables three-dimensional visualisation of low-absorbing materials. Dedicated phase retrieval algorithms can provide separate computed tomography (CT) maps of sample absorption, refraction and scattering properties. In this paper we propose a novel “modified local retrieval” method which is capable of accurately retrieving sample properties in a range of realistic, non-ideal imaging environments. These include system misalignment, defects in the used optical elements and system geometry variations over time due to vibrations or temperature fluctuations. System instabilities were analysed, modelled and incorporated into a simulation study. As a result, an additional modification was introduced to the retrieval procedure to account for changes in the imaging system over time, as well as local variations over the field of view. The performance of the proposed method was evaluated in comparison to a previously used "global retrieval" method by applying both approaches to experimental CT data of a rat’s heart acquired in a non-ideal environment. The use of the proposed method resulted in the removal of major artefacts, leading to a significant improvement in image quality. This method will therefore enable acquiring high-resolution, reliable CT data of large samples in realistic settings

Enhanced in vitro antitumor activity of a titanocene complex encapsulated into polycaprolactone (PCL) electrospun fibers.

PURPOSE: The purpose of this work was to achieve detailed biomaterials characterization of a drug delivery system for local cancer treatment based on electrospun titanocene trichloride-loaded resorbable polycaprolactone (PCL) fibers. METHODS: The PCL fibers were characterized for their structural, morphologic and physical properties. The drug release kinetics of the titanocene complex was investigated at different concentrations, to obtain a set of correlations between structure and tuneable release. After exposing cancer cells directly onto the surface of PCL fibers, the anti-proliferative effects of titanocene-loaded PCL were assessed by: (i) counting viable cells via live/dead staining methods, and (ii) analyzing cell apoptosis. RESULTS AND CONCLUSIONS: Titanocene concentration influenced fiber diameters reduced for PCL filled with titanocene. X-ray analysis suggested that the titanocene, encapsulated into the PCL fibers, is not allowed to crystallize and exists as amorphous aggregates into the fibers. The titanocene release curves presented two stages unrelated to PCL degradation: an initial burst release followed by a release linear with time, extending for a very long time. All of the titanocene-loaded fibers revealed sustained drug release properties suggesting their potential clinical applicability for the treatment of local cancer diseases