One-Shot Imitation Learning: A Pose Estimation Perspective

In this paper, we study imitation learning under the challenging setting of: (1) only a single demonstration, (2) no further data collection, and (3) no prior task or object knowledge. We show how, with these constraints, imitation learning can be formulated as a combination of trajectory transfer and unseen object pose estimation. To explore this idea, we provide an in-depth study on how state-of-the-art unseen object pose estimators perform for one-shot imitation learning on ten real-world tasks, and we take a deep dive into the effects that camera calibration, pose estimation error, and spatial generalisation have on task success rates. For videos, please visit https://www.robot-learning.uk/pose-estimation-perspective.Comment: Published at the 7th Conference on Robot Learning (CoRL 2023). For more details please visit https://www.robot-learning.uk/pose-estimation-perspectiv

Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines

Colorectal cancer; Epidermal growth factor receptor (EGFR); MAPK pathwayCàncer colorectal; Receptor epidèrmic de factor del creixement (EGFR); Via MAPKCáncer colorrectal; Receptor epidérmico de factor del crecimiento (EGFR); Vía MAPKBACKGROUND: Previous studies showed that the combination of an anti-Epidermal growth factor (EGFR) and a MEK-inhibitor is able to prevent the onset of resistance to anti-EGFR monoclonal antibodies in KRAS-wild type colorectal cancer (CRC), while the same combination reverts anti-EGFR primary resistance in KRAS mutated CRC cell lines. However, rapid onset of resistance is a limit to combination therapies in KRAS mutated CRC. METHODS: We generated four different KRAS mutated CRC cell lines resistant to a combination of cetuximab (an anti-EGFR antibody) and refametinib (a selective MEK-inhibitor) after continuous exposure to increasing concentration of the drugs. We characterized these resistant cell lines by evaluating the expression and activation status of a panel of receptor tyrosine kinases (RTKs) and intracellular transducers by immunoblot and qRT-PCR. Oncomine comprehensive assay and microarray analysis were carried out to investigate new acquired mutations or transcriptomic adaptation, respectively, in the resistant cell lines. Immunofluorescence assay was used to show the localization of RTKs in resistant and parental clones. RESULTS: We found that PI3K-AKT pathway activation acts as an escape mechanism in cell lines with acquired resistance to combined inhibition of EGFR and MEK. AKT pathway activation is coupled to the activation of multiple RTKs such as HER2, HER3 and IGF1R, though its pharmacological inhibition is not sufficient to revert the resistant phenotype. PI3K pathway activation is mediated by autocrine loops and by heterodimerization of multiple receptors. CONCLUSIONS: PI3K activation plays a central role in the acquired resistance to the combination of anti-EGFR and MEK-inhibitor in KRAS mutated colorectal cancer cell lines. PI3K activation is cooperatively achieved through the activation of multiple RTKs such as HER2, HER3 and IGF1R

Effect of temperature on the low-velocity impact response of environmentally friendly cork sandwich structures

Impact events are common in every-day life and can severely compromise the integrity and reliability of high-performing structures such as sandwich composites that are widespread in different industrial fields. Considering their susceptibility to impact damage and the environmental issues connected with their exploitation of synthetic materials, the present work aims to propose a bio-based sandwich structure with an agglomerated cork core and a flax/basalt intraply fabric as skin reinforcement and to address its main weakness, i.e. its impact response. In-service properties are influenced by temperature, therefore the effect of high (60 °C) and low (−40°C) temperatures on the impact behavior of the proposed structures was investigated and a suitable comparison with traditional (polyvinyl chloride) (PVC) foams was provided. The results highlighted the embrittlement effect of decreasing temperature on the impact resistance of the sole cores and skins and of the overall structures with a reduction in the perforation energy that shifted, in the last case, from 50–60 J at – 40 °C up to more than 180 J at 60 °C. A maleic anhydride coupling agent in the skins hindered fundamental energy dissipation mechanisms such as matrix plasticization, determining a reduction in the perforation threshold of all composites. In particular, neat polypropylene (PP) skins displayed a perforation energy of 20 J higher than compatibilized (PPC) ones at 60 °C, while agglomerated cork sandwich structures at 60 °C were characterized by a perforation threshold higher of at least 50 J.Publicad

The immediate impacts of COVID-19 on European electricity systems: a first assessment and lessons learned

The worldwide spread of the COVID-19 pandemic in 2020 forced most countries to intervene with policies and actions—including lockdowns, social-distancing and smart working measures—aimed at mitigating the health system and socio-economic disruption risks. The electricity sector was impacted as well, with performance largely reflecting the changes in the industrial and commercial sectors operations and in the social behavior patterns. The most immediate consequences concerned the power demand profiles, the generation mix composition and the electricity price trends. As a matter of fact, the electricity sectors experienced a foretaste of the future, with higher renewable energy penetration and concerns for security of supply. This paper presents a systemic approach toward assessing the impacts of the COVID-19 pandemic on the power sector. This is aimed at supporting decision making—particularly for policy makers, regulators, and system operators—by quantifying shorter term effects and identifying longer term impacts of the pandemic waves on the power system. Various metrics are defined in different areas—system operation, security, and electricity markets—to quantify those impacts. The methodology is finally applied to the European power system to produce a comparative assessment of the effects of the lockdown in the European context

The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark): study design and population

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Commitment of Autologous Human Multipotent Stem Cells on Biomimetic Poly-L-lactic Acid-Based Scaffolds Is Strongly Influenced by Structure and Concentration of Carbon Nanomaterial

Nanocomposite scaffolds combining carbon nanomaterials (CNMs) with a biocompatible matrix are able to favor the neuronal differentiation and growth of a number of cell types, because they mimic neural-tissue nanotopography and/or conductivity. We performed comparative analysis of biomimetic scaffolds with poly-L-lactic acid (PLLA) matrix and three different p-methoxyphenyl functionalized carbon nanofillers, namely, carbon nanotubes (CNTs), carbon nanohorns (CNHs), and reduced graphene oxide (RGO), dispersed at varying concentrations. qRT-PCR analysis of the modulation of neuronal markers in human circulating multipotent cells cultured on nanocomposite scaffolds showed high variability in their expression patterns depending on the scaffolds\u2019 inhomogeneities. Local stimuli variation could result in a multi- to oligopotency shift and commitment towards multiple cell lineages, which was assessed by the qRT-PCR profiling of markers for neural, adipogenic, and myogenic cell lineages. Less conductive scaffolds, i.e., bare poly-L-lactic acid (PLLA)-, CNH-, and RGO-based nanocomposites, appeared to boost the expression of myogenic-lineage marker genes. Moreover, scaffolds are much more effective on early commitment than in subsequent differentiation. This work suggests that biomimetic PLLA carbon-nanomaterial (PLLA-CNM) scaffolds combined with multipotent autologous cells can represent a powerful tool in the regenerative medicine of multiple tissue types, opening the route to next analyses with specific and standardized scaffold features

Effect of carbon nanostructures and fatty acid treatment on the mechanical and thermal performances of flax/polypropylene composites

Four different strategies for mitigating the highly hydrophilic nature of flax fibers were investigated with a view to increase their compatibility with apolar polypropylene. The effects of two carbon nanostructures (graphene nanoplatelets (GNPs) and carbon nanotubes (CNTs)), of a chemical modification with a fatty acid (stearic acid), and of maleated polypropylene on interfacial adhesion, mechanical properties (tensile and flexural), and thermal stability (TGA) were compared. The best performance was achieved by a synergistic combination of GNPs and maleated polypropylene, which resulted in an increase in tensile strength and modulus of 42.46% and 54.96%, respectively, compared to baseline composites. Stearation proved to be an effective strategy for increasing the compatibility with apolar matrices when performed in an ethanol solution with a 0.4 M concentration. The results demonstrate that an adequate selection of surface modification strategies leads to considerable enhancements in targeted properties