Benzofurano-isatins: Search for antimicrobial agents

In an attempt to find a new class of antimicrobial agents, a series of novel N′-(5 or 7 substituted-2-oxoindolin-3-ylidene)benzofuran-2-carbohydrazides 3(a–p) were synthesized by reacting benzofuran-2-carbohydrazide 1 with 5 and 7 substituted-isatins 2(a–p). The synthesized compounds were confirmed by melting point, IR, 1H NMR, 13C NMR and mass spectroscopy. All the synthesized compounds were screened for antimicrobial activity among the tested series, 3o exhibited excellent antibacterial activity against Escherichia coli and Pseudomonas vulgaris while 3p against Bacillus subtilis, E. coli and P. vulgaris (31.25 μg/mL) when compared with standards. Similarly 3o and 3p showed significant antifungal activity (31.25 μg/mL) when compared to fluconazole against Aspergillus niger

Rational design and synthesis of benzothiazolo-isatins for antimicrobial and cytotoxic activities

418-429In search of novel antimicrobial agents, a series new isatin derivatives <b style="mso-bidi-font-weight: normal">3a-p and 5a-p have been synthesized by condensation of isatins with 2-mercaptobenzothiazole acetic acid hydrazide and 2-hydrazinobenzothiazole respectively. Compounds synthesized have been evaluated for antibacterial and antifungal activity against various strains of bacteria and fungi as well as screened for their cytotoxic activity against HeLa and HBL-100 cell lines by MTT method. Some of the compounds 3k, <b style="mso-bidi-font-weight: normal">5j and 5o show significant antibacterial and antifungal activities when compared with standard drugs. Amongst them, compound 3k has been found to be relatively more effective and it is also observed that its action is against all the four strains of bacteria tested. Compound 5j shows noticeable degree of inhibition, specifically against gram-positive strains B. subtilis and S. aureus with average zone of inhibition 23 mm and 34 mm respectively. Compound 3a shows good antifungal action against both C. albicans and A. niger with<i style="mso-bidi-font-style: normal"> average zone of inhibition 10 mm each. The compound 3g is found to be most significant with IC50 values of 154.59 µM and 261.99 µM against HeLa and HBL-100 cell lines, respectively. </span