La mejora la educación bilingüe en Andalucía según los auxiliares de conversación

Bilingual education is present through a wide network of Andalusian centers in which foreign Language Assistants (LAs) perform their duties. The study investigates LAs´ representations of the teaching/learning processes that take place in bilingual classrooms, documenting their suggestions for improvement. A questionnaire with 81 items was designed and sent to all bilingual centers, with a total of 279 responses. The analysis of the quantitative data was undertaken through SPSS and the qualitative information was codified using ATLAS.ti. Among the results, three emerging categories stand out for the improvement of bilingual teaching, ideas linked to a) Content and Language Integrated Learning (CLIL) approach, b) classroom methodology, and c) the role of languages. The CLIL approach is positively evaluated, although LAs consider the need for an adjustment on the use of the foreign language according to the difficulty of the subject content. Regarding classroom methodology, teaching practices are described as teacher-centered, together with a considerable dependence on the textbook. Pertaining to the use of languages, the prominent role of the Spanish language is attested, intensified in cases in which teachers’ and students´ foreign language competence is lower. The conclusions point to the relevance of reinforcing the methodological and linguistic dimensions, thus requiring renewed efforts in terms of initial and ongoing teacher training.La enseñanza bilingüe se extiende por una amplia red de centros andaluces en las que desempeñan sus funciones auxiliares de conversación extranjeros. El estudio se acerca a los procesos de enseñanza/ aprendizaje que acontecen en las aulas bilingües y cómo se podrían mejorar según los auxiliares. Para la obtención de información se elaboró un cuestionario con 81 ítems que se envió a la totalidad de los centros bilingües andaluces, obteniendo 279 respuestas. El análisis de los datos cuantitativos se realizó a través de SPSS y los cualitativos fueron codificados con ATLAS.ti. Entre los resultados destacan tres categorías emergentes para la mejora de la enseñanza bilingüe vinculadas con el enfoque AICLE, la metodología y el uso de los idiomas en el aula. Los auxiliares validan el enfoque AICLE aunque reclaman una mejor adaptación del uso de la lengua extranjera para la enseñanza del contenido, especialmente cuando aumenta su complejidad. Con respecto a la metodología de aula se describen prácticas docentes expositivas, al primar la actividad del docente frente a la del alumnado, así como el uso generalizado del libro de texto. Con respecto al uso de los idiomas se atestigua el prominente papel del español, intensificado en aquellos casos en los que la competencia en L2 de docentes y alumnado es menor. Las conclusiones apuntan a la pertinencia de reforzar las dimensiones metodológicas y lingüísticas, siendo por tanto necesarios esfuerzos renovados en cuanto a la formación inicial y permanente

Validation of an Aptima-format Finnish new variant of Chlamydia trachomatis (FI-nvCT) surveillance assay, 2019

The Finnish new variant of Chlamydia trachomatis (FI-nvCT) is escaping diagnostics in Finland, Norway and Sweden. We have developed and validated an Aptima-format nucleic acid amplification test (NAAT) designed specifically to detect the FI-nvCT. This NAAT has high sensitivity (100%) and specificity (100%) for the FI-nvCT strain, enabling further investigation of the geographic distribution, prevalence and transmission of this diagnostic-escape mutant in screening populations in Europe.Peer reviewe

Closing Thoughts: On the Power of Youth and System Change

Change is happening in the Cooperative Extension System as the organization focuses its efforts on the overall goal of creating a culture of health in the United States. Well Connected Communities is a Cooperative Extension and National 4-H Council initiative supported by the Robert Wood Johnson Foundation that involves modeling a systems-level approach to community efforts versus an individual prevention model. The initiative also engages the power of youth to catalyze progress for communities to achieve their best health and well-being

Remote Sensing Of Rice-Based Irrigated Agriculture: A Review

The ‘Green Revolution’ in rice farming of the late 1960’s denotes the beginning of the extensive breeding programs that have led to the many improved rice varieties that are now planted on more than 60% of the world’s riceland (Khush, 1987). This revolution led to increases in yield potential of 2 to 3 times that of traditional varieties (Khush, 1987). Similar trends have also been seen in the Irrigation Areas and Districts of southern New South Wales (NSW) as the local breeding program has produced many improved varieties of rice adapted to local growing conditions since the 1960’s (Brennan et al., 1994). Increases in area of rice planted, rice quality, and paddy yield resulted (Brennan et al., 1994). Increased rice area, however, has led to the development of high water tables and risk of large tracts of land becoming salt-affected in southern NSW (Humphreys et al., 1994b). These concerns have led to various environmental regulations on rice in the region, culminating in 1994 when restrictions on rice area, soil suitability, and water consumption were fully enacted (Humphreys et al., 1994b). Strict environmental restrictions in combination with large areas of land make the management of this region a difficult task. Land managers require, among other things, a way of regulating water use, assessing or predicting crop area and productivity, and making management decisions in support of environmentally and economically sustainable agriculture. In the search for more time and cost effective methods for attaining these goals, while monitoring complex management situations, many have turned to remote sensing and Geographic Information System (GIS) technologies for assistance. The spectral information and spatial density of remote sensing data lends itself well to the measurement of large areas. Since the launch of LANDSAT-1 in 1972, this technology has been used extensively in agricultural systems for crop identification and area estimation, crop yield estimation and prediction, and crop damage assessment. The incorporation of remote sensing and GIS can also help integrate management practices and develop effective management plans. However, in order to take advantage of these tools, users must have an understanding of both what remote sensing is and what sensors are now available, and how the technology is being used in applied agricultural research. Accordingly, a description of both follows: first a description of the technology, and then how it is currently being applied. The applications of remote sensing relevant to this discussion can be separated into crop type identification; crop area measurement; crop yield; crop damage; water use/ moisture availability (ma) mapping; and water use efficiency monitoring/mapping. This report focuses on satellite remote sensing for broad-scale rice-based irrigation agricultural applications. It also discusses related regional GIS analyses that may or may not include remote sensing data, and briefly addresses other sources of finer-scale remote sensing and geospatial data as they relate to agriculture. Since a complete review of the remote sensing research was not provided in the rice literature alone, some generic agricultural issues have been learned from applications not specifically dealing with rice. Remote sensing specialists may wish to skip to section 2

Expression of Human Hipks in Drosophila Demonstrates Their Shared and Unique Functions in a Developmental Model

Homeodomain-interacting protein kinases (HIPKs) are a family of four conserved proteins essential for vertebrate development, as demonstrated by defects in the eye, brain, and skeleton that culminate in embryonic lethality when multiple HIPKs are lost in mice. While HIPKs are essential for development, functional redundancy between the four vertebrate HIPK paralogues has made it difficult to compare their respective functions. Because understanding the unique and shared functions of these essential proteins could directly benefit the fields of biology and medicine, we addressed the gap in knowledge of the four vertebrate HIPK paralogues by studying them in the fruit fly Drosophila melanogaster, where reduced genetic redundancy simplifies our functional assessment. The single hipk present in the fly allowed us to perform rescue experiments with human HIPK genes that provide new insight into their individual functions not easily assessed in vertebrate models. Further, the abundance of genetic tools and established methods for monitoring specific developmental pathways and gross morphological changes in the fly allowed for functional comparisons in endogenous contexts. We first performed rescue experiments to demonstrate the extent to which each of the human HIPKs can functionally replace Drosophila Hipk for survival and morphological development. We then showed the ability of each human HIPK to modulate Armadillo/β-catenin levels, JAK/STAT activity, proliferation, growth, and death, each of which have previously been described for Hipks, but never all together in comparable tissue contexts. Finally, we characterized novel developmental phenotypes induced by human HIPKs to gain insight to their unique functions. Together, these experiments provide the first direct comparison of all four vertebrate HIPKs to determine their roles in a developmental context

Analytical characteristics and comparative evaluation of Aptima HCV quant Dx assay with the Abbott RealTime HCV assay and Roche COBAS AmpliPrep/COBAS TaqMan HCV quantitative test v2.0

Abstract Background The Aptima HCV Quant Dx assay (Aptima assay) is a fully automated quantitative assay on the Panther® system. This assay is intended for confirmation of diagnosis and monitoring of HCV RNA in plasma and serum specimens. The purpose of the testing described in this paper was to evaluate the performance of the Aptima assay. Methods The analytical sensitivity, analytical specificity, precision, and linearity of the Aptima assay were assessed. The performance of the Aptima assay was compared to two commercially available HCV assays; the Abbott RealTime HCV assay (Abbott assay, Abbott Labs Illinois, USA) and the Roche COBAS Ampliprep/COBAS Taqman HCV Quantitative Test v2.0 (Roche Assay, Roche Molecular Systems, Pleasanton CA, USA). The 95% Lower Limit of Detection (LoD) of the assay was determined from dilutions of the 2nd HCV WHO International Standard (NIBSC 96/798 genotype 1) and HCV positive clinical specimens in HCV negative human plasma and serum. Probit analysis was performed to generate the 95% predicted detection limits. The Lower Limit of Quantitation (LLoQ) was established for each genotype by diluting clinical specimens and the 2nd HCV WHO International Standard (NIBSC 96/798 genotype 1) in HCV negative human plasma and serum. Specificity was determined using 200 fresh and 536 frozen HCV RNA negative clinical specimens including 370 plasma specimens and 366 serum specimens. Linearity for genotypes 1 to 6 was established by diluting armored RNA or HCV positive clinical specimens in HCV negative serum or plasma from 8.08 log IU/mL to below 1 log IU/mL. Precision was tested using a 10 member panel made by diluting HCV positive clinical specimens or spiking armored RNA into HCV negative plasma and serum. A method comparison was conducted against the Abbott assay using 1058 clinical specimens and against the Roche assay using 608 clinical specimens from HCV infected patients. In addition, agreement between the Roche assay and the Aptima assay using specimens with low HCV concentrations (</= 25 IU/mL by Roche) was tested using 107 clinical specimens. Results The 95% LoD was 5.1 IU/mL or lower for serum and 4.8 IU/mL or lower for plasma depending on the HCV genotype. The LLoQ for the assay was 10 IU/mL. Specificity was 100% with 95% confidence intervals of 99.6 to 100% for serum and plasma data combined. The assay demonstrated good linearity across the range for all genotypes. The Precision as estimated by the standard deviation (sd) was 0.17 log or lower across the range of the assay for both serum and plasma. HCV viral load results were compared using the Aptima assay and the Abbott assay giving a slope of 1.06, an intercept of 0.08 and an R2 of 0.98. HCV viral load results were compared for the Aptima and Roche assays giving a slope of 1.05, an intercept of −0.12 and an R2 of 0.96. Positive and negative agreement for the Aptima assay vs the Roche assay was 89% for low level specimens. Conclusion The Aptima assay is a highly sensitive and specific assay. The assay gave comparable HCV viral load results when compared to the Abbott and Roche assays. The performance of the Aptima assay makes it an excellent candidate for the detection and monitoring of HCV

A retrospective analysis of prescription medications as it correlates to falls for older adults

Objectives: To determine the correlation between falls and two medication factors: the class of medications and potentially inappropriate medications (PIMs) prescribed to community-dwelling older adults aged 55 and older. Methods: Retrospective, cross-sectional study. Home health patients residing in a Texas/Mexico border community and reporting at least one fall within the past month. Medication use, medication classification, and potentially inappropriate medications (PIM) recorded by level of falls; non-fallers and recurrent fallers. Results: Of 99 participants, 13.1% reported falling once and 86.9% reported two or more falls. Participant’s average number of medications used was 10.51 (SD 5.75) with 93.9% having four or more prescribed medications. Average number of PIMs prescribed per participant was 1.42 (SD 1.51) with at least one PIM prescribed to 65.6% of participants. Twenty three out of 83 identified classes of prescribed medications met criteria for the study’s analyses but resulted in no significant association to falls when comparing NF to RF. Agents acting on the renin-angiotensin system and lipid modifying agents were the most frequently prescribed medication classes (N=55, 55.6%). Ibuprofen was the PIM most frequently prescribed (n=13, 13.1%). The correlation between use of a prescribed PIM and number of falls was not statistically significant (p=0.128). Conclusions: There was no correlation between classes of medication and level of falls. Recurrent fallers were more likely to have been prescribed a PIM than non-fallers (not significant). Although the analyses conducted for this study did not result in statistical significance, the high prevalence of polypharmacy and prescribed PIMs observed in these participants warrants a thorough review of medications to reduce fall risks among older adults

PYRUVATE DEHYDROGENASE KINASE (PDK)

Abstract: Several oximes of triterpenes with a 17-~ hydroxyl and abietane derivatives are inlfibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 ~tmol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition

Measuring the Social Return on Investment of community sport and leisure facilities

Rationale/Purpose: There is a growing demand from managers and policy makers for evidence on the wider impacts of sport and physical activity. This is driven by the need to demonstrate accountability for public expenditure and effectiveness in relation to public policy. The research presented in this paper addresses a gap in knowledge relating to the social impact of local sport and leisure facilities. Design/methodology/approach: A Social Return on Investment (SROI) framework was used to measure the impact of sport and physical activity across 12 community sport and leisure facilities in Sheffield. A range of methods were used to measure general participation by regular visitors and a targeted therapeutic exercise programme for specific participants. Findings: The research found the social value of outcomes related to general and targeted participation were £21.67 m and £0.26 m, respectively, and that for every £1 spent a SROI of between £1.20 and £3.42 was generated. Practical implications: The research enables managers to identify the value of facilities beyond the financial indicators commonly used in performance management. Contribution: It contributes to knowledge on valuing the non-market benefits of sport. The research provides a methodological example of using SROI to measure the value of local sport and leisure facilities