Monolithic Microwave Integrated GaAs Electromagnetically-Coupled Antenna

Monolithic antenna on GaAs to be used in miniature active sensors is presented. After a first study of technological processes and the characterisation of various substrates in K-band, the feasibility of an antenna, operating in K-band, electromagnetically-coupled and integrated on GaAs by monolithical realisation, has been demonstrated. A low profile (1mm) and wide bandwidth (2.3 GHz around 25 GHz) antenna is obtained

Wideband compact antenna for K-band applications

A compact coupled microwave active antenna is presented. This antenna is proximity fed, and consists of a square radiating element array on a polymer dielectric layer. The compactness of the antenna is obtained through technological optical processes and the parasitic patch phenomenon which increases the bandwidth

Antennes intégrées multicouches. Caractérisation diélectriques et applications

Des procédés de réalisation d’antennes micro-ondes en technologie micro-rubans multicouches sont décrits. La gamme de fonctionnement des antennes s’étend jusqu’à 24 GHz. Une méthode originale de caractérisation à 24 GHz des propriétés diélectriques de la couche émissive de l’antenne est exposée. Un procédé innovant de réalisation de films diélectriques destinés à la conception d’antennes actives est exposé, ainsi que sa caractérisation de 2.45 à 24 GHz

Wideband compact antenna for K-band applications

International audienceA compact coupled microwave active antenna is presented. This antenna is proximity fed, and consists of a square radiating element array on a polymer dielectric layer. The compactness of the antenna is obtained through technological optical processes and the parasitic patch phenomenon which increases the bandwidth

Antennes intégrées multicouches. Caractérisation diélectriques et applications

International audienceDes procédés de réalisation d’antennes micro-ondes en technologie micro-rubans multicouches sont décrits. La gamme de fonctionnement des antennes s’étend jusqu’à 24 GHz. Une méthode originale de caractérisation à 24 GHz des propriétés diélectriques de la couche émissive de l’antenne est exposée. Un procédé innovant de réalisation de films diélectriques destinés à la conception d’antennes actives est exposé, ainsi que sa caractérisation de 2.45 à 24 GHz

Antennes intégrées multicouches. Caractérisation diélectriques et applications

International audienceDes procédés de réalisation d’antennes micro-ondes en technologie micro-rubans multicouches sont décrits. La gamme de fonctionnement des antennes s’étend jusqu’à 24 GHz. Une méthode originale de caractérisation à 24 GHz des propriétés diélectriques de la couche émissive de l’antenne est exposée. Un procédé innovant de réalisation de films diélectriques destinés à la conception d’antennes actives est exposé, ainsi que sa caractérisation de 2.45 à 24 GHz

On-line learning mathematics and sciences

info:eu-repo/semantics/nonPublishe

Exploring limits for data registration in the context of PROCARE, a quality improvement project on rectal cancer.

A high burden of registration in the context of quality improvement projects may result in registration fatigue.0Journal ArticleResearch Support, Non-U.S. Gov'tPROCAREinfo:eu-repo/semantics/publishe

Risk adjusted benchmarking of abdominoperineal excision for rectal adenocarcinoma in the context of the Belgian PROCARE improvement project.

The abdominoperineal excision (APE) rate, a quality of care indicator in rectal cancer surgery, has been criticised if not adjusted for confounding factors. This study evaluates variability in APE rate between centres participating in PROCARE, a Belgian improvement initiative, before and after risk adjustment. It also explores the effect of merging the Hartmann resections (HR) rate with that of APE on benchmarking.0Journal ArticlePROCARESCOPUS: ar.jinfo:eu-repo/semantics/publishe

Predicting the efficacy of anthracyclines in breast cancer (BC): The results of the TOP trial and their validation in the BIG 00-01 trial.

Abstract 1893 - Session :Molecular Markers for Detection and Predicting Therapeutic Response - Background: Anthracycline-based regimens are among the most active chemotherapies in BC. However, their use is associated with rare but significant toxicities and their efficacy may be restricted on a subset of BC patients (pts). Controversial results have been reported regarding the predictive value of topoisomerase II alpha (TOP2A), the molecular target of anthracyclines. Here, we report the results of the prospective TOP trial (NCT00162812) which was designed to identify markers of response/resistance to preoperative epirubicin in estrogen receptor (ER)-negative BC pts.Methods: Using pre-treatment biopsies, we analyzed TOP2A by fluorescence in situ hybridization (FISH, Abbott triple probe) and by immunohistochemistry (IHC, KiS1) and generated gene expression profiles (HG133Plus2.0). We used the publicly available data from the BIG00-01 trial (EORTC-10094;NCT00017095), which compared in a preoperative setting an anthracycline-based (A) to a taxane-based (T) regimen, to validate our results.Results: a) 149 pts were included in the TOP trial and 14.5% had a complete pathological response (pCR). b) A statistically significant correlation was observed between the mRNA levels (201292_s_at) and the FISH ratios (rho=0.42, p=0.00004), between mRNA and IHC (rho= 0.25, p=0.02) but not between FISH and IHC. c) TOP2A amplified tumors were characterized by an increased expression of genes telomeric to TOP2A and a decreased expression of HER2 and genes in its close proximity. d) TOP2A amplification (11% of the cases) was exclusively observed in HER2 amplified cases (=33% of the cases), and was predictive of pCR (k= 0.35, p=0.0002 - half of the patients with TOP2A amplification having a pCR). d). 57% of the samples overexpressed TOP2A but neither the protein levels nor the mRNA levels were predictive of pCR. e) Interestingly, a TOP2A gene expression module was predictive of response both in the HER2+ patients of the TOP trial and in the ER-/HER2+ patients of the BIG00-01 treated with A but not with T [Area Under the Curve (AUC): TOP: 0.86 (p=0.00001) and A-arm/BIG00-01: 0.81 (p= 0.0005)]. f) Stroma gene expression module defined previously (Desmedt et al. Clin Can Res2008) was associated with decreased pCR rates in the TOP trial and in ER-negative BIG00-01 pts treated with A but not with T, especially in HER2- pts [AUC: TOP: 0.31 (p=0.01) and A-arm/BIG00-01: 0.33 (p= 0.015)].Conclusions: This trial, which is the first to prospectively evaluate the predictive value of TOP2A in pts treated with epirubicin single-agent, supports TOP2A gene amplification, but not mRNA or protein overexpression, as a predictive marker. The analyses also shed light on the genes differentially expressed between TOP2A amplified and not amplified tumors. Finally, our results suggest that gene expression modules also predict relative efficacy to anthracyclines, both in HER2 positive and negative BC pts.info:eu-repo/semantics/publishe