Approccio alla caratterizzazione di un lembo di bosco vetusto: il caso di Monte Egitto

An integrated approach to characterize an old growth forest patch; the Monte Egitto case study Old growth forests, i.e. forests which have achieved a remarkable age without or with a very limited disturbance, are nowadays subject of detailed studies in order to understand their characters and capacity of ecosystems services providing. In Sicily only few wooded areas are classified as old growth forest, following the heavy land use change toward agriculture during the centuries. This paper reports the results of a study carried out to characterize the vegetation of a little crater on the Mount Etna, where a residual open wood of Quercus congesta (an endemic oak of Southern Italy) survived the year 1651 lava flows surrounding the crater. About 35 years ago inside the crater some areas were planted with Calabrian Black Pine. As a consequence today there is a remarkable competition between trees of the two species. An integrated approach monitoring was adopted, taking into account both trees and understory (herbs, shrubs and tree regeneration) characters as well as bird fauna, in order to describe the current situation and monitor the effect of pine plantation thinning aimed at favouring oak regeneration and reducing pine-oak competition

Influence of perineural invasion in predicting overall survival and disease-free survival in patients With locally advanced gastric cancer

Background The aim of the present study was to evaluate the prognostic significance of perineural invasion (PNI) in locally advanced gastric cancer patients who underwent D2 gastrectomy and adjuvant chemotherapy. Methods The records of a series of 103 patients undergoing D2 gastrectomy with curative intent combined with adjuvant chemotherapy from January 2004 to December 2014 were retrospectively reviewed. Results PNI was positive in 47 (45.6%) specimens. The 1-, 3-, and 5-year overall survival rates were 81%, 55%, and 42%, respectively. The 1-, 3-, and 5-year disease-free survival (DFS) rates were 76%, 57%, and 49%, respectively. A multivariate analysis showed that age number of positive lymph nodes, T stage, and PNI were independently associated with overall survival. Regarding DFS, the multivariate analysis showed that only PNI was independently associated with DFS. Conclusions PNI and T stage and positive lymph nodes are independent markers of poor prognosis in patients with gastric cancer. PNI should be incorporated in the postoperative staging system for planning follow-up after surgery and in our opinion to propose more aggressive postoperative therapies in PNI-positive patients

Enhancing the significance of gravitational wave bursts through signal classification

The quest to observe gravitational waves challenges our ability to discriminate signals from detector noise. This issue is especially relevant for transient gravitational waves searches with a robust eyes wide open approach, the so called all- sky burst searches. Here we show how signal classification methods inspired by broad astrophysical characteristics can be implemented in all-sky burst searches preserving their generality. In our case study, we apply a multivariate analyses based on artificial neural networks to classify waves emitted in compact binary coalescences. We enhance by orders of magnitude the significance of signals belonging to this broad astrophysical class against the noise background. Alternatively, at a given level of mis-classification of noise events, we can detect about 1/4 more of the total signal population. We also show that a more general strategy of signal classification can actually be performed, by testing the ability of artificial neural networks in discriminating different signal classes. The possible impact on future observations by the LIGO-Virgo network of detectors is discussed by analysing recoloured noise from previous LIGO-Virgo data with coherent WaveBurst, one of the flagship pipelines dedicated to all-sky searches for transient gravitational waves

Un generatore di impulso ad alta tensione per l'eccitazione di trasduttori piezoelettrici: un metodo per studiare la propagazione delle onde elastiche su campioni di rocce

Il dispositivo qui presentato è stato realizzato per lo studio della propagazione di onde elastiche in campioni di roccia [Wood A. W. Et al. 1955]. Mediante tale tecnica si riescono a determinare alcune caratteristiche fisiche delle rocce. Si tratta di un generatore di impulsi ad alta tensione, necessario per l’eccitazione di trasduttori piezoelettrici. La durata dell’impulso generato è di 1 s, l’ampiezza dell’ordine del kVolt. Il metodo utilizzato per effettuare la misura consiste nell’eccitare il trasduttore in trasmissione con un singolo impulso e quindi misurarne il tempo di volo con il trasduttore di ricezione. Il lavoro, oltre alla descrizione dello strumento, mostra alcuni esperimenti condotti su campioni di alluminio e diversi tipi di roccia. Tali esperimenti si sono resi necessari sia per il collaudo dello strumento che per la messa a punto del metodo

Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer

High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse. To improve treatment options, we must continue investigating tumor biology. Tumor characteristics (e.g., risk factors and epidemiology) are valuable clues to accomplish this task. The two most frequent risk factors for HGSOC are the lifetime number of ovulations, which is associated with increased oxidative stress in the pelvic area caused by ovulation fluid, and a positive family history due to genetic factors. In the attempt to identify novel genetic factors (i.e., genes) associated with HGSOC, we observed that several genes in linkage with HGSOC are expressed in the ciliated cells of the fallopian tube. This finding made us hypothesize that ciliated cells, despite not being the cell of origin for HGSOC, may take part in HGSOC tumor initiation. Specifically, malfunction of the ciliary beat impairs the laminar fluid flow above the fallopian tube epithelia, thus likely reducing the clearance of oxidative stress caused by follicular fluid. Herein, we review the up-to-date findings dealing with HGSOC predisposition with the hypothesis that fallopian ciliated cells take part in HGSOC onset. Finally, we review the up-to-date literature concerning genes that are located in genomic loci associated with epithelial ovarian cancer (EOC) predisposition that are expressed by the fallopian ciliated cells

Salmeterol and formoterol in partially reversible severe chronic obstructive pulmonary disease: a dose-response study

AbstractWhen testing the response to β2-agonist drugs in severe chronic obstructive pulmonary disease (COPD), a dose-response assessment should be undertaken. This study compares the time course of inhaled salmeterol (25, 50 and 75 μg) and formoterol (12, 24 and 36 μg) at different doses in a group of 12 patients with partially reversible, but severe COPD (FEV1 of 12–32% of predicted values after β2-agonist drugs had been withheld for 24 h). All doses of salmeterol and formoterol induced a significant (P<0·01) spirometric improvement over the 12-h monitoring period, when compared to the spirometric improvement after placebo, but while formoterol induced a dose-dependent increase of the FVC, FEV1 and FEF50, this was not the case for salmeterol. In fact, 75 μg salmeterol did not produce a further improvement of these parameters. Mean peak bronchodilation, expressed as the increase in FEV1 over baseline values, occurred 2 h after inhalation of the three doses of salmeterol, and 1 h after inhalation of the three doses of formoterol. A comparison of 50 μg salmeterol with 12 μg or 24 μg formoterol (clinically recommended doses), showed that improvement of FEV1 after salmeterol was statistically (P<0·05) higher than that after the two doses of formoterol, although the mean peak bronchodilations were similar. This was because salmeterol has a longer duration of action than formoterol. These data demonstrate that salmeterol is equally effective as, but longer-acting than, formoterol at clinically recommended doses in patients suffering from COPD, with severe airway obstruction. Moreover, these data suggest that 50 μg is the best dosage for salmeterol in these patients

Relating seismic velocities, thermal cracking and permeability in Mt. Etna and Iceland basalts

We report simultaneous laboratory measurements of seismic velocities and fluid permeability on lava flow basalt from Etna (Italy) and columnar basalt from Seljadur (Iceland). Measurements were made in a servo-controlled steady-state-flow permeameter at effective pressures from 5–80 MPa, during both increasing and decreasing pressure cycles. Selected samples were thermally stressed at temperatures up to 900 °C to induce thermal crack damage. Acoustic emission output was recorded throughout each thermal stressing experiment. At low pressure (0–10 MPa), the P-wave velocity of the columnar Seljadur basalt was 5.4 km/s, while for the Etnean lava flow basalt it was only 3.0–3.5 km/s. On increasing the pressure to 80 MPa, the velocity of Etnean basalt increased by 45%–60%, whereas that of Seljadur basalt increased by less than 2%. Furthermore, the velocity of Seljadur basalt thermally stressed to 900 °C fell by about 2.0 km/s, whereas the decrease for Etnean basalt was negligible. A similar pattern was observed in the permeability data. Permeability of Etnean basalt fell from about 7.5×10−16 m2 to about 1.5×10−16 m2 over the pressure range 5–80 MPa, while that for Seljadur basalt varied little from its initial low value of 9×10−21 m2. Again, thermal stressing significantly increased the permeability of Seljadur basalt, whilst having a negligible effect on the Etnean basalt. These results clearly indicate that the Etnean basalt contains a much higher level of crack damage than the Seljadur basalt, and hence can explain the low velocities (3–4 km/s) generally inferred from seismic tomography for the Mt. Etna volcanic edifice