Unusual echocardiographic finding leading to diagnosis of pulmonary sequestration

Pulmonary sequestration is an embryonic mass of non- functioning lung tissue that does not communicate with the tracheobronchial tree and has a reported incidence of 0.15%-6.4% of all the pulmonary malformations. This anomaly is classified as either intralobar or extralobar with the later variety lying outside the normal investment of visceral pleura. The arterial supply is predominantly by an anomalous artery usually arising from either abdominal or thoracic aorta, while the venous drainage occurs commonly via systemic rather than pulmonary veins. Identification of the anomalous arterial supply has therapeutic implication because the majority of infants clinically present large shunt lesions attributed to these channels in early infancy. The diagnosis in such cases is usually established by computed tomography (CT), angiography, magnetic resonance angiography and conventional angiography. This article reports a 28 day old neonate who presented with features of large shunt lesion, in which echocardiography was instrumental in the diagnosis of a large collateral supplying the sequestrated lung.peer-reviewe

The study of multifragmentation around transition energy in intermediate energy heavy-ion collisions

Fragmentation of light charged particles is studied for various systems at different incident energies between 50 and 1000 MeV/nucleon. We analyze fragment production at incident energies above, below and at transition energies using the isospin dependent quantum molecular dynamics(IQMD) model. The trends observed for the fragment production and rapidity distributions depend upon the incident energy, size of the fragments, composite mass of the reacting system as well as on the impact parameter of the reaction. The free nucleons and light charged particles show continous homogeneous changes irrespective of the transition energies indicating that there is no relation between the transition energy and production of the free as well as light charged particles

Investigation of current-voltage characteristics of Ni/GaN Schottky barrier diodes for potential hemt applications

In the present work, the I-V characteristics of Ni/GaN Schottky diodes have been studied. The Schottky diodes, having different sizes using Ni/Au and ohmic contacts using Ti/Al/Ni/Au were made on n-GaN. The GaN was epitaxially grown on c-plane sapphire by metal organic chemical vapor deposition (MOCVD) technique and had a thickness of about 3.7 μm. The calculated ideality factor and barrier height from current-voltage (I-V) characteristics (at 300 K) for two GaN Schottky diodes were close to ~1.3 and ~ 0.8 eV respectively. A high reverse leakage current in the order of 10 – 4A/cm2 (at – 1 V) was observed in both diodes. A careful analysis of forward bias I-V characteristics showed very high series resistance and calculation for ideality factor indicated presence of other current transport mechanism apart from thermionic model at room temperature. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2202

MOLECULAR DOCKING STUDIES OF SIDDHA HERBAL FORMULATION KUPPAIMENI CHOORNAM ON HUMAN HISTAMINE RECEPTOR (3RZE)

Background: Molecular docking has tremendous applications in the field of Siddha medicine especially herbal formulations were the interactions of the lead molecules of the formulation with that of receptors can be elucidated at the molecular level and furthermore to reach an assumption of its fundamental biochemical processes to which the formulation is targeting. Kuppaimeni Choornam (KC) is a simple herbal formulation used in Siddha medicine for urticaria and other skin allergies. As far as skin allergy is concerned Amino acids such as Asparagine (ASN), Tryptophan (Trp), Aspartate (Asp), Tyrosine (Tyr), Serine (Ser), Isoleucine (Ile), Lysine (Lys), Threonine (Thr), Phenylalanine (Phe) are the main core residues involved in mediating Human histamine receptor (3RZE). Binding of lead compounds with this core residue may inhibit the enzyme activity. Aim & Objectives: Molecular docking studies of Siddha herbal formulation KC and to screen the lead component interaction on the Human Histamine Receptor (3RZE). Methodology: Docking calculations were carried out using Auto Dock 4. Gasteiger partial charges were added to the ligand atoms. Docking simulations were performed using the Lamarckian genetic algorithm (LGA) and the Solis & Wets local search method. Initial position, orientation, and torsions of the ligand molecules were set randomly. All rotatable torsions were released during docking. Results and Conclusion: The compounds present in KC like beta-sitosterol, apigenin, luteolin, cuminaldehyde, kaempferol, and triacetonamine showed maximum interactions with 3RZE when compared to that of the standard cetirizine. Hence, these compounds of test drug possess promising Human histamine 1 receptor (3RZE) inhibition activity. For prospective pharmacological validation of Kuppaimeni Choornam, the docking studies were an important step for its scientific justification