Simulations on a potential hybrid and compact attosecond X-ray source based on RF and THz technologies

We investigate through beam dynamics simulations the potential of a hybrid layout mixing RF and THz technologies to be a compact X-ray source based on Inverse Compton Scattering (ICS), delivering few femtoseconds to sub-femtosecond pulses. The layout consists of an S-band gun as electron source and a dielectric-loaded circular waveguide driven by a multicycle THz pulse to accelerate and longitudinally compress the bunch, which will then be used to produce X-ray pulses via ICS with an infrared laser pulse. The beam dynamics simulations we performed, from the photocathode up to the ICS point, allows to have an insight in several important physical effects for the proposed scheme and also in the influence on the achievable bunch properties of various parameters of the accelerating and transverse focusing devices. The study presented in this paper leads to a preliminary layout and set of parameters able to deliver at the ICS point, according to our simulations, ultrashort bunches (around 1 fs rms), at 15 MeV, with at least 1 pC charge and transversely focused down to around 10 um rms or below while keeping a compact beamline (less than 1.5 m), which has not yet been achieved using only conventional RF technologies. Future studies will be devoted to the investigation of several potential ways to improve the achieved bunch properties, to overcome the limitations identified in the current study and to the definition of the technical requirements. This will lead to an updated layout and set of parameters.Comment: To be published in Nucl. Inst. Meth. A as proceedings of the EAAC17 conference 9 pages, 11 figure

Length Measurement of High-brightness Electron Beam thanks to the 3-Phase Method

ISBN 978-3-95450-132-8International audienceThe goal of 3-phase method is to determine the length of an electron beam without dedicated diagnostics by varying the measurement conditions of its energy spread, through a change in the RF phase of an accelerating structure. The originality here comes from the fact that it is applied on high-brightness electron beams of few MeV generated by RF photo-injectors. It allows testing the accuracy of 3-phase method, since the length to reconstruct is known as being that of the laser pulse generating the beam. It requires establishing the longitudinal transfer matrix of a RF photo-injector, which is difficult since the electron velocity vary from 0 to relativistic during its path*. The 3-phase method in RF photo-injector has been simulated by ASTRA and PARMELA codes, validating the principle of the method. First measurement has been done on PHIL accelerator at LAL, showing a good agreement with the expected length. I will then show results obtained at PITZ with a standing wave booster and a comparison with those coming from a Cerenkov detector. Finally, measurements at higher energy performed on the SOLEIL LINAC with travelling wave accelerating structures will be exposed

Status of Diamond Detector Development for Beam Halo Investigation at ATF2

Work supported by Chinese Scholarship Council - THPME092, ISBN 978-3-95450-132-8International audienceWe are developing a diamond detector for beam halo and Compton spectrum diagnostics after the interaction point (IP) of ATF2, a low energy (1.3 GeV) prototype of the final focus system for ILC and CLIC linear collider projects. Tests of a 500 μm thick sCVD diamond detector with a dimension of 4.5 mm×4.5 mm have been carried out with radioactive sources and with electron beam from PHIL low energy (<10 MeV) photo-injector at LAL. The tests at PHIL were done with different beam intensities in air, just after the exit window at the end of the beam line, to test the response of the diamond detector and the readout electronics. We have successfully detected signals from single electrons, using a 40 dB amplifier, and from an electron beam of 108 electrons, using a 24 dB attenuator. A diamond sensor with 4 strips has been designed and fabricated for installation in the vacuum chambers of ATF2 and PHIL, with the aim to scan both the beam halo (with 2 strips of 1.5 mm×4 mm) and the beam core (with 2 strips of 0.1 mm×4 mm) transverse distributions

MEASUREMENT OF LOW-CHARGED ELECTRON BEAM WITH A SCINTILLATOR SCREEN

Abstract Measuring electron beam charge lower than 1pC in an accelerator is very challenging since the traditional diagnostics, like Faraday Cup and ICT (Integrated Current Transformer), are limited in resolution to a few pC because of electronic noise. A way to simply measure lower charge would be then to use the linear relation, existing before saturation regime, between the incident charge on a scintillating screen and the total light intensity emitted in response by this screen. Measurements have been performed on PHIL accelerator at LAL, with charge lower than 200pC, with a LANEX screen located close to a Faraday Cup or an ICT. It shows a very good linear response of the screen down to the Faraday Cup and ICT resolution limits ( 3pC for the Faraday Cup and 10pC for the ICT) and therefore allows calibrating the screen for lower charge measurement with an estimated precision of 1% on the linear fit. A noise analysis enables estimating the ultimate screen resolution limit, which is actually dictated by the thermal noise of the CCD imaging the screen, around 10fC. Results of low charge measurements on PHIL will be shown and compared to those coming from a diamond detector installed on PHIL, in order to validate the measurement principle and cross-check both measurements. Such powerful and simple measurement may thereafter be used as a single-shot charge diagnostic for electron beam generated and accelerated by laser-plasma interaction and will be used in the context of the Dactomus projec

Characterization of relativistic electron bunch duration and travelling wave structure phase velocity based on momentum spectra measurements on the ARES linac at DESY

The ARES linac at DESY aims to generate and characterize ultrashort electron bunches (fs to sub-fs duration) with high momentum and arrival time stability for the purpose of applications related to accelerator R&D, e.g. development of advanced and compact diagnostics and accelerating structures, test of new accelerator components, medical applications studies, machine learning, etc. During its commissioning phase, the bunch duration characterization of the electron bunches generated at ARES has been performed with an RF-phasing technique relying on momentum spectra measurements, using only common accelerator elements (RF accelerating structures and magnetic spectrometers). The sensitivity of the method allowed highlighting different response times for Mo and Cs2Te cathodes. The measured electron bunch duration in a wide range of machine parameters shows excellent agreement overall with the simulation predictions, thus demonstrating a very good understanding of the ARES operation on the bunch duration aspect. The importance of a precise in-situ experimental determination of the phase velocity of the first travelling wave accelerating structure after the electron source, for which we propose a simple new beam-based method precise down to sub-permille variation respective to the speed of light in vacuum, is emphasized for this purpose. A minimum bunch duration of 20 fs rms, resolution-limited by the space charge forces, is reported. This is, to the best of our knowledge, around 4 times shorter than what has been previously experimentally demonstrated based on RF-phasing techniques with a single RF structure. The present study constitutes a strong basis for future time characterization down to the sub-fs level at ARES, using dedicated X-band transverse deflecting structures.Comment: 17 pages, 11 figures. To be submitted to Physical Review Accelerators and Beam

Should I Stay or Should I Go? A Habitat-Dependent Dispersal Kernel Improves Prediction of Movement

The analysis of animal movement within different landscapes may increase our understanding of how landscape features affect the perceptual range of animals. Perceptual range is linked to movement probability of an animal via a dispersal kernel, the latter being generally considered as spatially invariant but could be spatially affected. We hypothesize that spatial plasticity of an animal's dispersal kernel could greatly modify its distribution in time and space. After radio tracking the movements of walking insects (Cosmopolites sordidus) in banana plantations, we considered the movements of individuals as states of a Markov chain whose transition probabilities depended on the habitat characteristics of current and target locations. Combining a likelihood procedure and pattern-oriented modelling, we tested the hypothesis that dispersal kernel depended on habitat features. Our results were consistent with the concept that animal dispersal kernel depends on habitat features. Recognizing the plasticity of animal movement probabilities will provide insight into landscape-level ecological processes

Status and Objectives of the Dedicated Accelerator R&D Facility "SINBAD" at DESY

We present a status update on the dedicated R\&D facility SINBAD which is currently under construction at DESY. The facility will host multiple independent experiments on the acceleration of ultra-short electron bunches and novel, high gradient acceleration methods. The first experiment is the ARES-experiment with a normal conducting 100\,MeV S-band linac at its core. We present the objectives of this experiment ranging from the study of compression techniques to sub-fs level to its application as injector for various advanced acceleration schemes e.g. the plans to use ARES as a test-site for DLA experiments in the context of the ACHIP collaboration. The time-line including the planned extension with laser driven plasma-wakefield acceleration is presented. The second initial experiment is AXSIS which aims to accelerate fs-electron bunches to 15\,MeV in a THz driven dielectric structure and subsequently create X-rays by inverse Compton scattering.Comment: EAAC'17 conference proceeding

Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering

Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering. Multilayered constructs were formed by depositing the polyelectrolytes chitosan (CHT) and chondroitin sulphate (CS) on either bidimensional glass surfaces or 3D packet of paraffin spheres. 2D CHT/CS multi-layered constructs proved to support the attachment and proliferation of bovine chondrocytes (BCH). The technology was transposed to 3D level and CHT/CS multi-layered hierarchical scaffolds were retrieved after paraffin leaching. The obtained nanostructured 3D constructs had a high porosity and water uptake capacity of about 300%. Dynamical mechanical analysis (DMA) showed the viscoelastic nature of the scaffolds. Cellular tests were performed with the culture of BCH and multipotent bone marrow derived stromal cells (hMSCs) up to 21 days in chondrogenic differentiation media. Together with scanning electronic microscopy analysis, viability tests and DNA quantification, our results clearly showed that cells attached, proliferated and were metabolically active over the entire scaffold. Cartilaginous extracellular matrix (ECM) formation was further assessed and results showed that GAG secretion occurred indicating the maintenance of the chondrogenic phenotype and the chondrogenic differentiation of hMSCs

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p &lt; 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM &gt; 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM &gt; 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015

Titan: Earth-like on the outside, ocean world on the inside

Thanks to the Cassini-Huygens mission, Titan, the pale orange dot of Pioneer and Voyager encounters, has been revealed to be a dynamic, hydrologically shaped, organic-rich ocean world offering unparalleled opportunities to explore prebiotic chemistry. And while Cassini-Huygens revolutionized our understanding of each of the three "layers" of Titan-the atmosphere, the surface, and the interior-we are only beginning to hypothesize how these realms interact. In this paper, we summarize the current state of Titan knowledge and discuss how future exploration of Titan would address some of the next decade's most compelling planetary science questions. We also demonstrate why exploring Titan, both with and beyond the Dragonfly New Frontiers mission, is a necessary and complementary component of an Ocean Worlds Program that seeks to understand whether habitable environments exist elsewhere in our solar system