Redundant memory organization Patent

Redundant memory for enhanced reliability of digital data processing syste

New sintering process adjusts magnetic value of ferrite cores

A two-phase sintering technique based on time and temperature permits reversible control of the coercive threshold of sintered ferrite cores. Threshold coercivity may be controlled over a substantial range of values by selective control of the cooling rate

Hemodynamic Regulation Of Cardiac Valve Development

It is well established that valvulogenesis is a result of a complex interplay between genetic and environmental factors. Hemodynamics is one such environmental stimulus that is well documented to influence the development of heart valves. Using advanced imaging modalities, such as optical coherence tomography, investigators have better understood the effects of altering hemodynamic loads in the embryonic (avian) heart. However, the field of valvulogenesis is currently stagnant with a paucity of studies aiming to understand the molecular mechanisms influenced/affected by hemodynamic stimuli. Deciphering these pathways is critical from a valve development perspective, but also becomes vital as potential therapeutic targets, given the fact that several adult valve diseases have a congenital origin. Towards this end, we have developed a novel ex ovo method to alter hemodynamic stimuli through the chick embryonic heart by partially constricting the outflow tract (OFT). We acknowledge that the concept of banding a part of the developing heart has been exploited by several researchers; however, performing the banding intervention outside the eggshell not only highlights the novelty of our avian system, but also permits us to obtain sufficient tissue (from a statistical analysis standpoint) to carryout molecular biology experiments which was, until this point, impossible to achieve. Using this system, we have shown for the first time, that perturbation of intracardiac hemodynamics has consequences at the cellular and molecular level. Altered hemodynamics not only affected OFT cushion volume and expression of key players involved in valve development, but also led to a decrease in epithelial-mesenchymal-transition, a pivotal process in valvulogenesis. The migratory capacity and secretory profile of atrioventricular cushions were also altered by changing intracardiac hemodynamics. Furthermore, when the constriction around the OFT was removed, anomalous cardiac phenotypes, resulting due to OFT banding, could not be rescued, while the expression of some genes returned to that observed in control tissue. Lastly, OFT banding seemed to have an influence on gene expression only if hemodynamics were altered at a certain developmental period. However, expression of collagen appeared sensitive to altered blood flow through the embryonic heart even at very early periods of embryonic development

The Contribution Of Visceral Fat To Positive Insulin Signaling In Ames Dwarf Mice

Ames dwarf (df/df) mice are homozygous for a spontaneous mutation in the prop1 gene due to which there is no development of anterior pituitary cells – somatotrophs, lactotrophs and thyrotrophs, leading to a deficiency of growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). They tend to become obese as they age, but still live longer and healthier lives compared to their wild-type littermates, being very insulin sensitive, showing no signs of diabetes and cancer. These mutant mice also have high circulating levels of anti-inflammatory and antidiabetic adiponectin. Plasma levels of this adipokine usually decrease with an increase in accumulation of visceral fat (VF). We thus believe that VF in df/df mice, developed in the absence of GH signaling, may be functionally different from the same fat depots in normal (N) mice and may be beneficial, rather than detrimental, to the overall health of the animal. We performed surgeries involving removal of VF depots (epididymal and perirenal fat) in both groups of mice and hypothesize that the beneficial effects of visceral fat removal (VFR) will be present exclusively in N mice as VF in df/df mice contributes to enhanced insulin sensitivity by producing decreased levels of pro-inflammatory adipokines like TNF and IL-6. We found that VFR improved insulin sensitivity only in N mice but not in the df/df mice. This intervention led to an upregulation of certain players of the insulin signaling pathway in the skeletal muscle of N mice only, with no alteration in df/df mice. The subcutaneous fat of df/df mice showed a downregulation of these insulin signaling genes upon VFR. Compared to N mice, epididymal fat of df/df mice (sham-operated) had increased gene expression of some of the players involved in insulin signaling and a decrease in transcript levels of TNFa. Ames dwarf mice had decreased levels of IL-6 protein in EF and in circulation. High circulating levels of adiponectin and iv decreased levels of IL-6 in circulation could contribute to the high insulin sensitivity observed in the Ames dwarf mice. Understanding the mechanisms responsible for VF having positive effects on insulin signaling in df/df mice would be important for future treatment of obese diabetic patients

The Contribution Of Visceral Fat To Positive Insulin Signaling In Ames Dwarf Mice

Ames dwarf (df/df) mice are homozygous for a spontaneous mutation in the prop1 gene due to which there is no development of anterior pituitary cells – somatotrophs, lactotrophs and thyrotrophs, leading to a deficiency of growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). They tend to become obese as they age, but still live longer and healthier lives compared to their wild-type littermates, being very insulin sensitive, showing no signs of diabetes and cancer. These mutant mice also have high circulating levels of anti-inflammatory and antidiabetic adiponectin. Plasma levels of this adipokine usually decrease with an increase in accumulation of visceral fat (VF). We thus believe that VF in df/df mice, developed in the absence of GH signaling, may be functionally different from the same fat depots in normal (N) mice and may be beneficial, rather than detrimental, to the overall health of the animal. We performed surgeries involving removal of VF depots (epididymal and perirenal fat) in both groups of mice and hypothesize that the beneficial effects of visceral fat removal (VFR) will be present exclusively in N mice as VF in df/df mice contributes to enhanced insulin sensitivity by producing decreased levels of pro-inflammatory adipokines like TNF and IL-6. We found that VFR improved insulin sensitivity only in N mice but not in the df/df mice. This intervention led to an upregulation of certain players of the insulin signaling pathway in the skeletal muscle of N mice only, with no alteration in df/df mice. The subcutaneous fat of df/df mice showed a downregulation of these insulin signaling genes upon VFR. Compared to N mice, epididymal fat of df/df mice (sham-operated) had increased gene expression of some of the players involved in insulin signaling and a decrease in transcript levels of TNFa. Ames dwarf mice had decreased levels of IL-6 protein in EF and in circulation. High circulating levels of adiponectin and iv decreased levels of IL-6 in circulation could contribute to the high insulin sensitivity observed in the Ames dwarf mice. Understanding the mechanisms responsible for VF having positive effects on insulin signaling in df/df mice would be important for future treatment of obese diabetic patients

Space-Efficient Knot Mosaics of Size 7

Mosaic knot theory is a young and exciting area of mathematics. Since it is still in its mathematical infancy, there are many basic questions still unanswered. The main goal of the field is to represent knots on a square grid using a certain set of tiles. From those tiles we can build knot projections. The smallest n × n grid that each knot with crossing number 10 or less can fit on is unknown. In this paper, we explain how we developed a program that creates and identifies every knot on a 7 × 7 mosaic, and we find every knot with crossing number 10 or less that can fit on a 7-mosaic with tile number 27 or 29

Hushaby Ma\u27 Honey

https://digitalcommons.library.umaine.edu/mmb-vp/1625/thumbnail.jp

Enhancing Criminal Penalties for Catastrophic Discharges: Closing a Clean Water Act Loophole That a Leaking Supertanker Can Sail Through

The Exxon Valdez incident in Alaska has greatly increased public awareness of the amount of environmental damage which can result from a large discharge of pollutants. This disaster has lead Congress to consider toughening penalties for a variety of environmental violations. The author discusses proposed environmental catastrophe legislation which would empower federal judges to impose criminal sentences of up to thirty years for certain environmental crimes. Aside from the severity of the proposed penalties, the most controversial aspect of the bill is that it focuses on the resulting environmental damage rather than the polluting act itself

The respiratory system of the Carolina locust (Dissosteira carolina Linn.)

The present paper, which is offered as a portion of a thesis for the degree of Master of Science at the Massachusetts Agricultural College, is one of a series of studies being conducted at this institution on the anatomy of the Carolina locust for the purpose of furnishing a description of the morphology of a common and widely distributed insect which is both primitive in its organization and of sufficient size to be readily dissected. In the preparation of this paper I have received much encouragement and assistance from Dr. H. T. Fernald, Dr. G. C. Crampton, and Dr. V. S. Regan, and I would take this opportunity of expressing my appreciation of their kindly interest and advice

School of Law_Law Building Closure Email

Email from Nicole Vinal Harvie, Assistant Dean for Finance and Administration University of Maine School of Law Chief Staff Officer University of Maine School of Law Foundation regarding the termination of student access to the Law Building on March 13, 2020