Exploring the pathway from radicalisation to disengagement : comparison of dissonances experienced by a Jihadi foreign fighter and a right-wing extremist

The aim of our article is to analyse the disengagement process of a Swiss returnee from Syria and the emergence of dissonances during his involvement with the Islamic State (IS) and to compare this evolution to the pathway of a right-wing extremist willing to leave the violent extremist group Blood & Honour. Although the contexts of these extremist groups are very different, a number of elements – as the ideology based on hate, the groups’ internal pressure and the affinity for violence – are quite similar. The disengagement process of both extremists is analysed by means of reconstructive methods and the theory of cognitive dissonance (Festinger 1957), as well as by the current state of research on disengagement processes. This serves as a theoretical framework. The findings show that comparing their pathway to defection reveals a number of parallels: the experiences within the extremist groups, especially violent acts against group members, increased their dissonances and provided a trigger to an opening process and ultimately the attempt to opt out of the group

Inhibition of IL-1, IL-6, and TNF-α in immune-mediated inflammatory diseases

Blockade of cytokines, particularly of tumour necrosis factor alpha (TNF-α), in immuno-inflammatory diseases, has led to the greatest advances in medicine of recent years. We did a thorough review of the literature with a focus on inflammation models in rodents on modified gene expression or bioactivity for IL-1, IL-6, and TNF-α, and we summarized the results of randomized controlled clinical trials in human disease. What we have learned herewith is that important information can be achieved by the use of animal models in complex, immune-mediated diseases. However, a clear ranking for putative therapeutic targets appears difficult to obtain from an experimental approach alone. This is primarily due to the fact that none of the disease models has proven to cover more than one crucial pathogenetic aspect of the complex cascade of events leading to characteristic clinical disease signs and symptoms. This supports the notion that the addressed human immune-mediated diseases are polygenic and the summation of genetic, perhaps epigenetic, and environmental factors. Nevertheless, it has become apparent, so far, that TNF-α is of crucial importance in the development of antigen-dependent and antigen-independent models of inflammation, and that these results correlate well with clinical success. With some delay, clinical trials in conditions having some relationship with rheumatoid arthritis (RA) indicate new opportunities for blocking IL-1 or IL-6 therapeutically. It appears, therefore, that a translational approach with critical, mutual reflection of simultaneously performed experiments and clinical trials is important for rapid identification of new targets and development of novel treatment options in complex, immune-mediated, inflammatory disease

Operative Eingriffe an Hand und Handgelenk

Zusammenfassung: Trotz der heute zur Verfügung stehenden Biologika bleiben das synovialitisch bedingte Karpaltunnelkompressionssyndrom, das Caput-ulnae-Syndrom oder palmar betonte Tenosynovialitiden mit drohenden Sehnenrupturen dringliche chirurgische Indikationen an der Hand. Die diagnostische und therapeutische Synovektomie zur Diagnose- und Therapieoptimierung behält ihren Stellenwert, nach Möglichkeit bevor radiologisch fassbare Destruktionen auftreten. Balance- oder gelenkstabilisierende Operationen müssen vor der Destruktion der Gelenke angeboten werden. Wird dieser Zeitpunkt verpasst, so können am Handgelenk meist nur noch Teil- oder komplette Arthrodesen, an den Grundgelenken Arthroplastiken und an den Endgelenken Arthrodesen durchgeführt werde

Explaining differences in reading motivation between immigrant and native students: The role of parental involvement

Immigrant students usually report high levels of academic interest and motivation compared to their native peers. Given the important role that parents play in fostering their children’s academic motivation, this article focuses on aspects of parental involvement and analyzes possible mediator effects on the students’ reading motivation and achievement using structural equation modeling. The analyses were conducted with data from N = 891 Swiss fourth-graders and their families. Immigrant students received less emotional support from their parents, although the latter had significantly higher expectations for their child’s reading achievement. Furthermore, the three aspects of parental involvement investigated had a significant impact on the development of reading motivation. In mediation analyses, just one of the 12 effects tested appeared to be a mediation effect. Further research is needed to explain differences in motivation between immigrant and native students

Equilibrium and Fractional Crystallization Experiments at 0·7 GPa; the Effect of Pressure on Phase Relations and Liquid Compositions of Tholeiitic Magmas

Two series of anhydrous experiments have been performed in an end-loaded piston cylinder apparatus on a primitive, mantle-derived tholeiitic basalt at 0·7 GPa pressure and temperatures in the range 1060-1270°C. The first series are equilibrium crystallization experiments on a single basaltic bulk composition; the second series are fractionation experiments where near-perfect fractional crystallization was approached in a stepwise manner using 30°C temperature increments and starting compositions corresponding to that of the previous, higher temperature glass. At 0·7 GPa liquidus temperatures are lowered and the stability of olivine and plagioclase is enhanced with respect to clinopyroxene compared with phase equilibria of the same composition at 1·0 GPa. The residual solid assemblages of fractional crystallization experiments at 0·7 GPa evolve from dunites, followed by wehrlites, gabbronorites, and gabbros, to diorites and ilmenite-bearing diorites. In equilibrium crystallization experiments at 0·7 GPa dunites are followed by plagioclase-bearing websterites and gabbronorites. In contrast to low-pressure fractionation of tholeiitic liquids (1 bar-0·5 GPa), where early plagioclase saturation leads to the production of troctolites followed by (olivine) gabbros at an early stage of differentiation, pyroxene still crystallizes before or with plagioclase at 0·7 GPa. The liquids formed by fractional crystallization at 0·7 GPa evolve through limited silica increase with rather strong iron enrichment following the typical tholeiitic differentiation path from basalts to ferro-basalts. Silica enrichment and a decrease in absolute iron and titanium concentrations are observed in the last fractionation step after ilmenite starts to crystallize, resulting in the production of an andesitic liquid. Liquids generated by equilibrium crystallization experiments at 0·7 GPa evolve through constant SiO2 increase and only limited FeO enrichment as a consequence of spinel crystallization and closed-system behaviour. Empirical calculations of the (dry) liquid densities along the liquid lines of descent at 0·7 and 1·0 GPa reveal that only differentiation at the base of the crust (1·0 GPa) results in liquids that can ascend through the crust and that will ultimately form granitoid plutonic and/or dacitic to rhyodacitic sub-volcanic to volcanic complexes; at 0·7 GPa the liquid density increases with increasing differentiation as a result of pronounced Fe enrichment, rendering it rather unlikely that such differentiated melt will reach shallow crustal level

The remission of rheumatoid arthritis during pregnancy

Rheumatoid arthritis (RA) is an autoimmune disease that is favorably influenced by pregnancy but relapses after delivery. A variety of circulating factors has been considered as candidates for inducing gestational improvement of RA; however, the factors/pathways responsible remain still elusive. This review discusses recent research on the effect of pregnancy on RA with a focus on immunregulation, cytokine secretion, HLA antigens, microchimerism, and innate immunity. The complex hormonal and immunological alterations of pregnancy may temporarily correct the disturbed immunregulation of R