45 research outputs found
Landscape homogenization due to agricultural intensification disrupts the relationship between reproductive success and main prey abundance in an avian predator
Selecting high-quality habitat and the optimal time to reproduce can increase individual fitness and is a strong evolutionary factor shaping animal populations. However, few studies have investigated the interplay between land cover heterogeneity, limitation in food resources, individual quality and spatial variation in fitness parameters. Here, we explore how individuals of different quality respond to possible mismatches between a cue for prey availability (land cover heterogeneity) and the actual fluctuating prey abundance.Peer reviewe
Does index tumor predominant location influence prognostic factors in radical prostatectomies?
Asymptotic Solution of Thermocapillary Convection in a Differentially Heated Thin Annular Two-Layer Pool
Reduction of Qm Protein Expression Correlates with Tumor Grade in Prostatic Adenocarcinoma
The QM protein is a transcription cofactor inhibiting the activity of AP-1 transcription factors and is also a ribosomal protein participating in protein synthesis. While protein synthesis is known to be increased in many cancers, inhibition of AP-1 activity presumably suppresses development and growth of sex-hormone-regulated tumor cells. The present study is the first report on immunohistochemical data of QM in human prostatic tissues. Paraffin sections of human prostate cancer samples were immunohistochemically stained for QM. The staining scores were analyzed with the clinicopathologic data of the patients. QM protein expression was found in all normal prostate glands adjacent to prostate cancer and in various intraepithelial neoplasia ( PIN). In prostate cancer, the staining intensity and stained areas were decreased, compared to the normal glands and PIN lesions; in high-grade tumors only some patches of tumor cells showed positivity. Intense (3+) staining was mostly observed in the Gleason grade three areas (48%) compared to grade 4 and 5 areas (22%), although both low and high-grade tumors showed similar percentages of weakly stained areas. Moreover, staining in prostatic adenocarcinoma was often topographically patchy and varied from negative or weak (1+) to intense (3+). There was an inverse correlation from normal to low-grade tumors and then to high-grade tumors. However, in high-grade tumors, the positive areas were mostly confined to peripheral aspects of tumors and were particularly strong in foci of perineural invasion. This preliminary study suggests that decreased QM expression may be associated with early development of prostate cancer, but later a high level of QM may facilitate progression of the tumors to a more aggressive phenotype.WoSScopu
miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration
Robot-assisted laparoscopic radical prostatectomy: an athermal anterior approach to the seminal vesicle dissection
Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells
Prostate Tumor Volume Measurement with Combined T2-weighted Imaging and Diffusion-weighted MR: Correlation with Pathologic Tumor Volume1
Combined T2-weighted and diffusion-weighted MR imaging performed by using an apparent diffusion coefficient cutoff value of 0.0016 mm2/sec is significantly more accurate than T2-weighted imaging alone in the measurement of tumor volume in the peripheral zone of the prostate