Measurements of the cosmic background radiation

Maps of the large scale structure (theta is greater than 6 deg) of the cosmic background radiation covering 90 percent of the sky are now available. The data show a very strong 50-100 sigma (statistical error) dipole component, interpreted as being due to our motion, with a direction of alpha = 11.5 + or - 0.15 hours, sigma = -5.6 + or - 2.0 deg. The inferred direction of the velocity of our galaxy relative to the cosmic background radiation is alpha = 10.6 + or - 0.3 hours, sigma = -2.3 + or - 5 deg. This is 44 deg from the center of the Virgo cluster. After removing the dipole component, the data show a galactic signature but no apparent residual structure. An autocorrelation of the residual data, after substraction of the galactic component from a combined Berkeley (3 mm) and Princeton (12 mm) data sets, show no apparent structure from 10 to 180 deg with a rms of 0.01 mK(sup 2). At 90 percent confidence level limit of .00007 is placed on a quadrupole component

A novel haptic model and environment for maxillofacial surgical operation planning and manipulation

This paper presents a practical method and a new haptic model to support manipulations of bones and their segments during the planning of a surgical operation in a virtual environment using a haptic interface. To perform an effective dental surgery it is important to have all the operation related information of the patient available beforehand in order to plan the operation and avoid any complications. A haptic interface with a virtual and accurate patient model to support the planning of bone cuts is therefore critical, useful and necessary for the surgeons. The system proposed uses DICOM images taken from a digital tomography scanner and creates a mesh model of the filtered skull, from which the jaw bone can be isolated for further use. A novel solution for cutting the bones has been developed and it uses the haptic tool to determine and define the bone-cutting plane in the bone, and this new approach creates three new meshes of the original model. Using this approach the computational power is optimized and a real time feedback can be achieved during all bone manipulations. During the movement of the mesh cutting, a novel friction profile is predefined in the haptical system to simulate the force feedback feel of different densities in the bone

Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain.

Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). CNVs represent a significant source of genetic variation in the human genome and have been implicated in several disorders and complex traits, representing a potential mechanism that contributes to neuronal diversity and the etiology of several neurological diseases and provides new insights into the normal, complex functions of the brain. Nonetheless, the features of somatic CNV mosaicism in nondiseased elderly brains have not been investigated. In the present study, we demonstrate a highly significant increase in the number of CNVs in nondiseased elderly brains compared to the blood. In two neural tissues isolated from paired postmortem samples (same individuals), we found a significant increase in the frequency of deletions in both brain areas, namely, the frontal cortex and cerebellum. Also, deletions were found to be significantly larger when present only in the cerebellum. The sizes of the variants described here were in the 150-760 kb range, and importantly, nearly all of them were present in the Database of Genomic Variants (common variants). Nearly all evidence of genome structural variation in human brains comes from studies detecting changes in single cells which were interpreted as derived from independent, isolated mutational events. The observations based on array-CGH analysis indicate the existence of an extensive clonal mosaicism of CNVs within and between the human brains revealing a different type of variation that had not been previously characterized

Spillover and diffraction sidelobe contamination in a double-shielded experiment for mapping Galactic synchrotron emission

We have analyzed observations from a radioastronomical experiment to survey the sky at decimetric wavelengths along with feed pattern measurements in order to account for the level of ground contamination entering the sidelobes. A major asset of the experiment is the use of a wire mesh fence around the rim-halo shielded antenna with the purpose of levelling out and reducing this source of stray radiation for zenith-centered 1-rpm circular scans. We investigate the shielding performance of the experiment by means of a geometric diffraction model in order to predict the level of the spillover and diffraction sidelobes in the direction of the ground. Using 408 MHz and 1465 MHz feed measurements, the model shows how a weakly-diffracting and unshielded antenna configuration becomes strongly-diffracting and double-shielded as far-field diffraction effects give way to near-field ones. Due to the asymmetric response of the feeds, the orientation of their radiation fields with respect to the secondary must be known a priori before comparing model predictions with observational data. By adjusting the attenuation coefficient of the wire mesh the model is able to reproduce the amount of differential ground pick-up observed during test measurements at 1465 MHz.Comment: 14 pages, 17 eps + 1 gif figures and 4 Tables. Accepted for publication in A&AS. Fig.7 available at full resolution from http://www.das.inpe.br/~tello/publications.ht

Evidence for a Very Large-Scale Fractal Structure in the Universe from Cobe Measurements

In this work, we analyse the temperature fluctuations of the cosmic microwave background radiation observed by COBE and show that the distribution can be fitted by a fractal distribution with a fractal dimension $D= 1.43 \pm 0.07$. This value is in close agreement with the fractal dimension obtained by Coleman and Pietronero (1992) and Luo and Schramm (1992) from galaxy-galaxy and cluster-cluster correlations up to $\sim 100 h^{-1} Mpc$. The fact that the observed temperature fluctuations correspond to scales much larger than $100 h^{-1} Mpc$ and are signatures of the primordial density fluctuations at the recombination layer suggests that the structure of the matter at the early universe was already fractal and thus non-homogeneous on those scales. This result may have important consequences for the theoretical framework that describes the universe.Comment: 11 pages, postscript file, 2 figures available upon request. To appear in ApJ Letter

A method to search for topological signatures in the angular distribution of cosmic objects

We present a method to search for large angular-scale correlations, termed topological signatures, in the angular distribution of cosmic objects, which does not depend on cosmological models or parameters and is based only on the angular coordinates of the objects. In order to explore Cosmic Microwave Background temperature fluctuations data, we applied this method to simulated distributions of objects in thin spherical shells located in three different multiply-connected Euclidean 3-spaces ($T^3$, $T_{\pi}$, and $G_6$), and found that the topological signatures due to these topologies can be revealed even if their intensities are small. We show how to detect such signatures for the cases of full-sky and partial-sky distributions of objects. This method can also be applied to other ensembles of cosmic objects, like galaxies or quasars, in order to reveal possible angular-scale correlations in their distributions.Comment: 11 pages, 18 figures. To appear in A&