551 research outputs found

    Evapotranspiration simulated by CRITERIA and AquaCrop models in stony soils

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    The performance of a water balance model is also based on the ability to correctly perform simulations in heterogeneous soils. The objective of this paper is to test CRITERIA and AquaCrop models in order to evaluate their suitability in estimating evapotranspiration at the field scale in two types of soil in the Mediterranean region: non-stony and stony soil. The first step of the work was to calibrate both models under the non-stony conditions. The models were calibrated by using observations on wheat crop (leaf area index or canopy cover, and phenological stages as a function of degree days) and pedo-climatic measurements. The second step consisted in the analysing the impact of the soil type on the models performances by comparing simulated and measured values. The outputs retained in the analysis were soil water content (at the daily scale) and crop evapotranspiration (at two time scales: daily and crop season). The model performances were evaluated through four statistical tests: normalised difference (D%) at the seasonal time scale; and relative root mean square error (RRMSE), efficiency index (EF), coefficient of determination (r2) at the daily scale. At the seasonal scale, values of D% were less than 15% in stony and on-stony soils, indicating a good performance attained by both models. At the daily scale, the RRMSE values (2) indicate the inadequacy of AquaCrop to simulate correctly daily evapotranspiration. The higher performance of CRITERIA model to simulate daily evapotranspiration in stony soils, is due to the soil submodel, which requires the percentage skeleton as an input, while AquaCrop model takes into account the presence of skeleton by reducing the soil volume

    Energy consumption and analysis of industrial drying plants for fresh pasta process

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    The article presents results concerning the energy needs and the CO2 emissions resulting from the production process of a small factory (located in Molise region) producing fresh pasta. Two production processes are responsible for the most of energy demand. The pasteurisation and the drying processes are responsible for the 50% of the electricity consumption and the whole thermal energy. Therefore innovative solutions have been studied in order to limit the energy requirements and the CO2 emissions. Such solutions take into account the adoption of high-efficiency motors and heat recovery in the main processes

    evapotranspiration of tomato simulated with the criteria model

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    The CRITERIA model simulates crop development and water dynamics in agricultural soils at different spatial scales. The objective of this paper was to test CRITERIA in order to evaluate the suitability of the model as a tool for scheduling irrigation at field scale. The first step of the work was to validate this hypothesis, by means of calibration and validation of CRITERIA on processing tomato in two experimental sites in Southern Italy (Rutigliano and Foggia) for the years 2007 and 2008 under different irrigation regimes. The irrigation treatments were: i) absence of plant water stress (the control treatments set up for both years and sites), ii) moderately stressed (applied in Rutigliano for 2007), and iii) severely stressed (applied in Foggia for 2008). The second step consisted in the evaluation of the expected impact of different irrigation regimes on daily actual evapotranspiration. For model calibration, the 2007 data of the control treatment was used, whereas in the validation process of actual evapotranspiration, the other part of the dataset was used. The observed data were crop evapotranspiration, agrometeorological data, leaf area index, physical-chemical and hydrological characteristics of soil, phenological stages and irrigation management. In order to evaluate model performance we used three statistical indicators to compare simulated and measured values of actual evapotranspiration: the normalized differences of seasonal values are less than 10% for all treatments; the model efficiency index on the typical period between two irrigations (4 days) was positive for all treatments, with the best values in the Foggia site, for both the irrigated and the severely stressed experiments; the relative root mean square error (RRMSE) was smaller than 20% in both the control treatments, but higher than 30% for the stressed treatments. The increase in RRMSE for the stressed experiments is due to CRITERIA simulating a crop in good soil water conditions and, as a consequence, with a larger evapotranspiration demand with respect to water stressed crop. Therefore, we can consider CRITERIA as a suitable tool to manage irrigations of processed tomato, especially for the full irrigation regime; an improvement can be reached by simulating the impact of water stress conditions on the eco-physiological parameters of the crop, in order to use the model also under deficit irrigation regimes

    Lifestyle Modifications to Help Prevent Headache at a Developmental Age

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    Headache is the world’s seventh most significant cause of disability-adjusted-life in people aged between 10 and 14 years. Therapeutic management is based on pharmacological approaches and lifestyle recommendations. Many studies show associations between each migraine-promoting lifestyle, behavioral triggers, frequency, and intensity of headaches. Nevertheless, the overall aspects of this topic lack any definitive evidence. Educational programs advise that pediatric patients who suffer from migraines follow a correct lifestyle and that this is of the utmost importance in childhood, as it will improve quality of life and assist adult patients in avoiding headache chronicity, increasing general well-being. These data are important due to the scarcity of scientific evidence on drug therapy for prophylaxis during the developmental age. The “lifestyle recommendations” described in the literature include a perfect balance between regular sleep and meal, adequate hydration, limited consumption of caffeine, tobacco, and alcohol, regular physical activity to avoid being overweight as well as any other elements causing stress. The ketogenic diet is a possible new therapeutic strategy for the control of headache in adults, however, the possible role of dietary factors requires more specific studies among children and adolescents. Educational programs advise that the improvement of lifestyle as a central element in the management of pediatric headache will be of particular importance in the future to improve the quality of life of these patients and reduce the severity of cephalalgic episodes and increase their well-being in adulthood. The present review highlights how changes in different aspects of daily life may determine significant improvements in the management of headaches in people of developmental age

    Characterization of an in vitro model to study the role of human Polyomavirus BK in prostate cancer

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    Prostate cancer (PCa) is one of the most common male neoplasm in the western world, being the most commonly diagnosed non-skin cancer and the second leading cause of cancer death. Various potential risk factors exist for the initial triggering events, including exposure to infectious agents, such as the human Polyomavirus BK (BKV). BKV is a good candidate as risk factor of PCa because it naturally infects the human reno-urinary tract, it establishes latency, and encodes oncoproteins that interfere with tumor suppressors pathways, thus altering the normal progression of cell cycle. Previous studies suggested a potential association between BKV and PCa, revealing that the prevalence of BKV was significantly higher in cancer than in control tissues, with a significant association between viral expression and cancer. However, this hypothesis is controversial because BKV is not restricted to tumor tissues but also infects healthy individuals in a high percentage. Moreover, an in vitro model of BKV infection in prostate cells is not available to understand the role for BKV in pathogenesis of PCa. Our aims were to determine whether BKV a) could infect normal epithelial prostate cells, b) affects cell phenotype and c) affects the phenotype of human prostate tumor cell line PC3. For this purpose normal epithelial prostate cell line RWPE-1 and prostate cancer cells PC3 were infected with BKV for 21 days. Cell proliferation, epithelial-to-mesenchymal markers (EMT) and invasion potential were analyzed by, respectively, MTT, immunofluorescence and SDS-zymography. Our results show that cell proliferation was increased or decreased by BKV, respectively, in RWPE-1 and PC3 cells. BKV induced E-cadherin downregulation and vimentin expression in both control and BKV-infected cells RWPE-1, suggesting that uninfected cells underwent EMT. Matrix metalloproteinase-2 and 9 activity was increased in RWPE-1 cells after BKV infection. By contrast, BKV did not significantly modified the phenotype of PC3 cells. These preliminary results suggest that normal epithelial prostate cells RWPE-1 and PC3 are susceptible and permissive to BKV infection. However, RWPE-1 cells exhibit some phenotype modifications related to EMT, possibly induced by the papilloma virus used to obtain their immortalization, thus suggesting that further experiments will be necessary to define if they represent a good experimental model to study prostate cancer

    Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19

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    The established risk factors of coronavirus disease 2019 (COVID-19) are advanced age, male sex and comorbidities, but they do not fully explain the wide spectrum of disease manifestations. Genetic factors implicated in the host antiviral response provide for novel insights into its pathogenesis. We performed an in-depth genetic analysis of chromosome 21 exploiting the genome-wide association study data, including 6,406 individuals hospitalized for COVID-19 and 902,088 controls with European genetic ancestry from the COVID-19 Host Genetics Initiative. We found that five single nucleotide polymorphisms within TMPRSS2 and near MX1 gene show associations with severe COVID-19. The minor alleles of the five SNPs correlated with a reduced risk of developing severe COVID-19 and high level of MX1 expression in blood. Our findings demonstrate that host genetic factors can influence the different clinical presentations of COVID-19 and that MX1 could be a potential therapeutic target

    Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020

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    Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results of an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day-17.7 years, 55.9% males), of which 67.9% were hospitalised and 19.6% had comorbidities. Fever was the most common symptom, gastrointestinal manifestations were frequent; two children required intensive care, five had seizures, 49 received experimental treatments and all recovered

    Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

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    We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound-detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross-sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, -0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40-ligand (P = 0.0238), soluble Nox2-derived peptide (sNox2-dp; P < 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD4OL (Spearman's rank correlation coefficient [r(s)], -0.33; P < 0.001), sNox2-dp (r(s), -0.57; P < 0.0001), and urinary excretion of isoprostanes (r(s), -0.48; P < 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2-dp, and urinary 8-iso prostaglandin F2 alpha-III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2-dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation
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