Development of new nano-enhanced phase change materials (NEPCM) to improve energy efficiency in buildings: Lab-scale characterization

Fatty acids are promising organic phase change materials (PCMs) for thermal energy storage (TES) in buildings because of their high storage capacity, non-toxic nature and little subcooling. Their phase change temperatures make them suitable for heating, ventilating and air conditioning (HVAC) applications in the building sector. However, one of their main drawbacks is their poor thermal conductivity which limits their application. In the present study two fatty acids within the building application temperature range, capric acid (CA) and capric-myristic acid (CA-MA) eutectic mixture, were nano-enhanced throughout silicon dioxide nanoparticles (nSiO2) addition (0.5 wt.%, 1.0 wt.% and 1.5 wt.%). Main properties of the nano-enhanced phase change materials (NEPCM) obtained were characterized by means of differential scanning calorimetry (DSC), Hot wire technique, Fourier transformed infrared (FT-IR) spectroscopy, thermogravimetric analyses (TGA), scanning electron microscopy (SEM), and rheological measurements. Furthermore, their long-term performance was evaluated after 2000 cycles by means of cycling stability tests. The NEPCM obtained showed high thermal conductivity and specific heat capacity. Additionally, both are thermally stable within their working temperature range and ensure a long-term performance

Bibliografía [Cuadernos del Instituto Antonio de Nebrija de estudios sobre la Universidad. 1998, nº 1]

Paz Alonso. Universidad y sociedad corporativa (Pascual Marzal). -- Ana LLano Torres, Salvador Rus Rufino. Historia del pensamiento filosófico y jurídico (M. Martínez Neira). -- María Fernanda Mancebo. La Universidad de Valencia. De la Monarquía a la República (1919-1939) (Marc Baldó). -- Margarita Torremocha Hernández. La vida estudiantil en el antiguo régimen (Enrique Villalba).-- Elena Vázquez Sánchez. Un historiador del derecho, Pedro José Pidal (M. Martínez Neira).-- Ceremonial sagrado y político de la Universidad de Salamanca (Enrique Villalba).-- Doctores y escolares (M. Martínez Neira)Publicad

Assessment of young people’s exposure to alcohol marketing in audiovisual and online media.

Alcohol use among young people, and adolescents in particular, is an increasing concern in Europe. Children and adolescents have greater vulnerability to alcohol than adults and there is increasing evidence of the impact of drinking on young people’s health, both short and long term, including the increased likelihood of being in a risky situation when drunk. There are many factors that may encourage alcohol use among young people, and alcohol marketing has been identified as one potential influence. Evidence strongly suggests that alcohol advertising will increase the likelihood that adolescents will start to drink alcohol at a young age and may increase alcohol use among those who already consume alcohol. It is against this background that the European Commission Health and Consumer Directorate-General (DG SANCO), by way of the EAHC, has commissioned RAND Europe to carry out an assessment of young people’s exposure to alcohol marketing through television and online media. The overall aim of the work presented in this report was to use novel approaches to measure alcohol advertisement exposure among young people in Europe through audiovisual and online media. Our analyses used a range of methods. First, to assess young people’s exposure to alcohol marketing in television, we used commercially available data on television audiences (‘viewership’) and on alcohol advertising in the UK, the Netherlands and Germany. We applied descriptive statistics and regression analysis to estimate the exposure of young people to alcohol advertising compared with that of adults. Second, we analysed alcohol advertising portrayals of a sample of alcohol adverts broadcast in each of the three countries to better understand the extent to which advertisements are using elements that have been identified as appealing to young people. In a third step, we assessed the extent to which alcohol portrayals in these adverts adhere to national statutory or voluntary codes on (alcohol) advertising in each country, and with policies developed by alcohol manufacturers themselves. Fourth, we explored exposure to alcohol marketing in online media, here focusing on the UK. We examined data on online media channels accessed by young people, described the main types of social media marketing messages for alcoholic beverages, and assessed the use of age gates to restrict content to those over the legal drinking age

Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus angustifolia Vahl) in Human Healthy Volunteers: A Preliminary Study

The bark, seeds, fruits and leaves of the genus Fraxinus (Oleaceae) which contain a wide range of phytochemicals, mostly secoiridoid glucosides, have been widely used in folk medicine against a number of ailments, yet little is known about the metabolism and uptake of the major Fraxinus components. The aim of this work was to advance in the knowledge on the bioavailability of the secoiridoids present in a Fraxinus angustifolia Vahl seed/fruit extract using both targeted and untargeted metabolomic analyses. Plasma and urine samples from nine healthy volunteers were taken at specific time intervals following the intake of the extract and analyzed by UPLC-ESI-QTOF. Predicted metabolites such as tyrosol and ligstroside-aglycone glucuronides and sulfates were detected at low intensity. These compounds reached peak plasma levels 2 h after the intake and exhibited high variability among the participants. The ligstroside-aglycone conjugates may be considered as potential biomarkers of the Fraxinus secoiridoids intake. Using the untargeted approach we additionally detected phenolic conjugates identified as ferulic acid and caffeic acid sulfates, as well as hydroxybenzyl and hydroxyphenylacetaldehyde sulfate derivatives which support further metabolism of the secoiridoids by phase I and (or) microbial enzymes. Overall, the results of this study suggest low uptake of intact secoiridoids from a Fraxinus angustifolia Vahl extract in healthy human volunteers and metabolic conversion by esterases, glycosidases, and phase II sulfo- and glucuronosyl transferases to form smaller conjugated derivatives.This work was financially supported by the Centre for the Development of Industrial Technology (CDTI) from the Spanish Government (NEMAF project) and R.G.V., P.F-B. and M-T.G.C. are participating to the COST Action FA1403 Positive (Interindividual variation in response to consumption of plant food bioactives and determinants involved). We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI).Peer reviewe

The extent to which genetics and lean grade affect fatty acid profiles and volatile compounds in organic pork

Niche production is intended to produce premium pork, but several husbandry factors may affect the meat fatty acid composition and aroma. Fatty acid profile (by GC-FID) of raw meat and volatile compounds (by SPME-GC-MS) of cooked meat were analysed in loin samples from two pig genetic types-75% Duroc (Du) and 50% Pietrain (Pi) rossbreds that were slaughtered at different weights (90 kg and 105 kg, respectively) to achieve similar target carcass fatness, and the outcome carcasses were balanced for lean grade groups (<60% or ≥60% lean) within genotypes. Genetic type did not affect fatty acids (FA) profile of meat. The leaner meat had lower C12:0 and C20:3n − 3, lower saturated fatty acids (SFA) and higher MUFA/SFA ratio content than the fattier meat. Short-chain alcohols were lower in Pietrain and in leaner pork compared to the samples from Duroc crossbreds and fattier pork. A greater amount of hexane,2,4,4-trimethyl (an aliphatic hydrocarbon) but lower carbon disulphide (sulphur compound) content was detected in pork from leaner compared to fattier pork. Higher aromatics hydrocarbons were exclusively associated with Duroc crossbreds, and lower aliphatic hydrocarbons with pigs classified as fattier. Most of the volatile compounds detected in the present study came from lipid oxidation.José Manuel Lorenzo is a member of the MARCARNE network, funded by CYTED (ref.116RT0503). The funders had no role in study design, data collection and analysis, decisionto publish, or preparation of the manuscript

miR-141 and miR-200c as markers of overall survival in early stage non-small cell lung cancer adenocarcinoma

Several treatments in non-small cell lung cancer (NSCLC) are histology-dependent, and the need for histology-related markers is increasing. MicroRNAs (miRNAs) are promising molecular markers in multiple cancers and show differences in expression depending on histological subtype. The miRNA family miR-200 has been associated with the regulation of epithelial-mesenchymal (EMT)/mesenchymal-epithelial transition (MET). EMT involves profound phenotypic changes that include the loss of cell-cell adhesion, the loss of cell polarity, and the acquisition of migratory and invasive properties that facilitates metastasis. A dual role for the miR-200 family in the prognosis of several tumors has been related to tumor cell origin. However, the prognostic role and function of miR-200 family in early-stage NSCLC adenocarcinoma and squamous cell carcinoma (SCC) have not been well established. Methods: miRNA expression was determined using TaqMan assays in 155 tumors from resected NSCLC patients. Functional studies were conducted in three NSCLC cell lines: H23, A-549 and HCC-44. Results: High miR-200c expression was associated with shorter overall survival (OS) in the entire cohort (p = 0.024). High miR-200c (p = 0.0004) and miR-141 (p = 0.009) expression correlated with shorter OS in adenocarcinoma - but not in SCC. In the multivariate analysis, a risk score based on miR-141 and miR-200c expression emerged as an independent prognostic factor for OS in the entire cohort (OR, 2.787; p = 0.033) and in adenocarcinoma patients (OR, 10.649; p = 0.002). Functional analyses showed that miR-200c, was related to mesenchymal-epithelial transition (MET) and affected cell migration and E-cadherin levels, while overexpression of miR-141 reduced KLF6 protein levels and produced an increase of secretion of VEGFA in vitro (H23, p = 0.04; A-549, p = 0.03; HCC-44, p = 0.02) and was associated with higher blood microvessel density in patient tumor samples (p<0.001). Conclusion: High miR-141 and miR-200c expression are associated with shorter OS in NSCLC patients with adenocarcinoma through MET and angiogenesis