6,840 research outputs found
Geometry, stochastic calculus and quantum fields in a non-commutative space-time
The algebras of non-relativistic and of classical mechanics are unstable
algebraic structures. Their deformation towards stable structures leads,
respectively, to relativity and to quantum mechanics. Likewise, the combined
relativistic quantum mechanics algebra is also unstable. Its stabilization
requires the non-commutativity of the space-time coordinates and the existence
of a fundamental length constant. The new relativistic quantum mechanics
algebra has important consequences on the geometry of space-time, on quantum
stochastic calculus and on the construction of quantum fields. Some of these
effects are studied in this paper.Comment: 36 pages Latex, 1 eps figur
Stratification of the orbit space in gauge theories. The role of nongeneric strata
Gauge theory is a theory with constraints and, for that reason, the space of
physical states is not a manifold but a stratified space (orbifold) with
singularities. The classification of strata for smooth (and generalized)
connections is reviewed as well as the formulation of the physical space as the
zero set of a momentum map. Several important features of nongeneric strata are
discussed and new results are presented suggesting an important role for these
strata as concentrators of the measure in ground state functionals and as a
source of multiple structures in low-lying excitations.Comment: 22 pages Latex, 1 figur
Soft singularity and the fundamental length
It is shown that some regular solutions in 5D Kaluza-Klein gravity may have
interesting properties if one from the parameters is in the Planck region. In
this case the Kretschman metric invariant runs up to a maximal reachable value
in nature, i.e. practically the metric becomes singular. This observation
allows us to suppose that in this situation the problems with such soft
singularity will be much easier resolved in the future quantum gravity then by
the situation with the ordinary hard singularity (Reissner-Nordstr\"om
singularity, for example). It is supposed that the analogous consideration can
be applied for the avoiding the hard singularities connected with the gauge
charges.Comment: 5 page
Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom.
We previously demonstrated that Bothrops jararaca venom (BjV) has an antitumor effect on Ehrlich ascites tumor (EAT) cells and induces an increase of polymorphonuclear leukocytes in early stages of tumor growth. It has been reported that this venom presents an important inflammatory effect when inoculated in animal models and in human snakebites, and that cytokine levels have been detected in these cases. To evaluate whether the cytokines can be involved with the suppression of the tumoral growth, we evaluate the cytokine profile in the peritoneal cavity of mice inoculated with EAT cells and treated with BjV. Swiss mice were inoculated with EAT cells by the intraperitoneal route and treated with BjV venom (0.4 mg/kg, intraperitoneally), on the 1st, 4th, 7th, 10th, and 13th day. Mice were evaluated for cytokine levels on the 2nd, 5th, 8th, 11th and 14th day. Analysis was performed using an enzyme-linked immunosorbent assay for interleukin (IL)-1alpha, IL-2, IL4, IL-6, IL-10, IL-13, and tumor necrosis factor-alpha (TNF-alpha) levels in the peritoneal washing supernatant. Results were analyzed statistically by the Kruskal-Wallis and Dunn's tests at the 5% level of significance. We observed that EAT implantation induces IL-6 production on the 11th and 14th days of tumor growth, IL-10 on the 11th day and TNF-alpha on the 14th day. The treatment with BjV suppresses production of these cytokines. In addition, IL-13 was produced by animals that were inoculated only with venom on the 11th and 14th days, and by the group inoculated with EAT cells and treated with venom on the 2nd and 14th days. Furthermore, we suggest that the IL-6 detected in the present study is produced by the EAT cells and the suppression of its production could be associated with the antitumor effect of BjV
Antitumor effect of Bothrops jararaca venom.
Many experimental studies have been carried out using snake venoms for the treatment of animal tumors, with controversial results. While some authors have reported an antitumor effect of treatment with specific snake venom fractions, others have reported no effects after this treatment. The aim of this study was to evaluate the effect of Bothrops jararaca venom (BjV) on Ehrlich ascites tumor (EAT) cells in vivo and in vitro. In the in vivo study, Swiss mice were inoculated with EAT cells by the intraperitoneal (i.p.) route and treated with BjV venom (0.4 mg/kg, i.p.), on the 1st, 4th, 7th, 10th, and 13th days. Mice were evaluated for total and differential cells number on the 2nd, 5th, 8th, 11th and 14th days. The survival time was also evaluated after 60 days of tumor growth. In the in vitro study, EAT and normal peritoneal cells were cultivated in the presence of different BjV concentrations (2.5, 5.0, 10.0, 20.0, 40.0, and 80 microg) and viability was verified after 3, 6, 12 and 24 h of cultivation. Results were analyzed statistically by the Kruskal-Wallis and Tukey tests at the 5% level of significance. It was observed that in vivo treatment with BjV induced tumor growth inhibition, increased animal survival time, decreased mortality, increased the influx of polymorphonuclear leukocytes on the early stages of tumor growth, and did not affect the mononuclear cells number. In vitro treatment with BjV produced a dose-dependent toxic effect on EAT and peritoneal cells, with higher effects against peritoneal cells. Taken together, our results demonstrate that BjV has an important antitumor effect. This is the first report showing this in vivo effect for this venom
Calagem e adubação para pastagens na região do cerrado.
Calagem e adubação para o estabelecimento. ExigĂŞncia de fertilidade do solo das principais gramĂneas e leguminosas forrageiras. Calagem. Adubação. Calagem e Adubação para manutenção. Considerados finais.bitstream/item/72180/1/cirtec-37.pdf2. ed. rev.CNPGC
PHYSIOLOGICAL RESPONSES OF HOLSTEIN COW’S FACE TO RESOURCE OF FAN IN FREE-STALL
Este estudo teve como objetivo avaliar a influĂŞncia do recurso de ventilação sobre a fisiologia de vacas Holandesas alojadas em free-stall, durante o verĂŁo do sudeste brasileiro. Foram utilizadas 20 vacas Holandesas submetidas a dois tratamentos: controle e ventilação. Os parâmetros ambientais registrados foram temperatura e umidade relativa do ar e temperatura de globo negro. As variáveis fisiolĂłgicas avaliadas foram temperatura retal e frequĂŞncia respiratĂłria. Para obtenção das estatĂsticas descritivas utilizou-se a metodologia de quadrados mĂnimos. Apesar das diferenças estatĂsticas obtidas para as variáveis fisiolĂłgicas, as mesmas nĂŁo foram biologicamente efetivas e indicaram que os animais se encontravam em conforto tĂ©rmico
- …