Exploration Of Robotics Need In The Medical Field And Robotic Arm Operation Via Glove Control

This thesis project is an exercise in getting hands-on experience in redesigning and modifying a robotic system. It also involves understanding the current need for robotic applications in hospital settings. To achieve the above, a thorough literature review of the current state of robotics in a hospital setting was conducted. Moreover, a number of interviews with medical care professionals were completed. Three main themes were obtained from the literature review and five main themes were obtained from the interviews which will be presented in this thesis report. The next phase of the project involved redesigning a system that is composed of two main parts: a glove and a robotic arm. The glove consists of multiple flex sensors and an inertial measurement unit (IMU) that sends data to an Arduino, which processes the data and sends a signal through Bluetooth transmission to the robotic arm. The robotic arm consists of servo motors that move according to the signal that is received from the glove. The results of the current performance of the system will be presented

IN VITRO ANTIOXIDANT PROPERTIES AND TOTAL PHENOLIC AND FLAVONOID CONTENTS OF RUMEX VESICAIUS L.

Objective: The aim of the study was to investigate the total phenolic and total flavonoids contents and evaluate the antioxidant potential of different solvent extracts of Rumex vesiarius L.Methods: The antioxidant potential of the hexane, ethyl acetate and methanol extract by using FRAP, LPO and Peroxidase assays and free radical scavenging by using DPPH and ABTS were determined. These activities were determined by using standard protocols with some modifications. Aluminium chloride colorimetric method was used to estimate TFC (total flavonoid content) and TPC (total phenolic content) was measured by Folin-ciocalteu method.Results: Among the test extracts methanol extract exhibited strong antioxidant activity than that of hexane and ethyl acetate. Free radicals, DPPH and ABTS were significantly inhibited by methanol extract of leaf and fruit (IC50 174.91±17.96 μg/ml and 526.791±91.85 mM min-1g-1DW), whereas methanolic extract of leaves showed good antioxidant potential using FRAP (306±14.8 mM min-1g-1DW) and LPO (30.57±5.65 MDA g-1DW) methods, while Peroxidase was were strongly inhibited by ethyl acetate extract of flower (0.624±0.013 mM min-1g-1DW). The maximum total phenolic and total flavonoids content was observed in leaves (0.53±0.31 mg GAE/gm DW and 2.15±0.72 mg QE/gm DW).Conclusion: The present investigation suggested that methanol extracts of Rumex vesicarius has significant antioxidant activity. These results clearly indicate that R. vesicarius is effective against free radical mediated diseases. These crude extracts can further purify and may be considered as a new source for antioxidant pharmaceutical compounds.Â

Analiza fitochemiczna oraz ocena aktywności mięczakobójczej Andrographis paniculata

Andrographis paniculata Nees (Acanthaceae), commonly known as “Kalmegh” is traditionally used medicinal plant. In present study the laboratory evaluations were made to assess the preliminary phytochemical screening and molluscicidal activity of Andrographis paniculata. Maximum extractive value (3.134%) was found in water extract among test solvents. All the tested metabolites were qualitatively present in ethanolic extract. Regarding molluscicidal activity, the acute toxicity of the extracts on Lymnaea acuminata was evaluated by a rapid screening procedure. Among the different plant parts (root, stem and leaf) powder and ethanolic extract showed LC50 at 295.55mg/L and 19.73mg/L respectively. Screening of plant extracts represents a continuous effort to find new antiparasitic drugs.Andrographis paniculata Nees (Acanthaceae) jest tradycyjną rośliną leczniczą powszechnie znaną jako „Kalmegh”. W niniejszej pracy zaprezentowano wyniki wstępnych badań dotyczących analizy fitochemicznej oraz oceny aktywności mięczakobójczej Andrographis paniculata. Najwyższą wydajność ekstrakcji odnotowano w przypadku wyciągu wodnego – 3,134%, natomiast wszystkie bioaktywne metabolity były obecne w ilościach oznaczalnych w wyciągu alkoholowym. W przypadku działania mięczakobójczego oznaczono toksyczność ostrą z użyciem Lymnaea acuminata za pomocą szybkiego testu przesiewowego. Najwyższą LC50 spośród badanych części roślin (korzenie, łodyga i liście) odnotowano dla sproszkowanych korzeni oraz wyciągu alkoholowego, odpowiednio LC50=295,55 mg/L i 19,73 mg/L. Analiza wyciągów roślinnych potwierdza słuszność przeprowadzania dalszych badań mających na celu poszukiwanie nowych leków przeciwpasożytniczych

Investigation of Anti-Inflammatory, Analgesic and Antipyretic Properties of Gmel

The crude methanolic extract of Madhuca indica (Sapotaceae) at 50,100 and 200 mg/kg body weight was evaluated for anti-inflammatory, analgesic and antipyretic activities in male wistar rats. Anti-inflammatory activity was studied by using carrageenan-induced oedema right hind paw volume while the analgesic effect was evaluated using acetic acid-induced abdominal pains, i.e. nociception response and the brewer's yeast-induced pyrexia model was used for antipyretic investigation. Phytochemical screening of the alcoholic extract revealed the presence of cardiac glycosides, flavonoids, saponins, steroids, tannins and terpenes. All the doses of the plant methanolic extract and the indomethacin significantly inhibited carrageenan-induced inflammation that was not dose-dependent. The plant extract reduced the acetic acid-induced pain licking. The plant extract reduced the brewer's yeast-provoked elevated body temperature in rats after 60 mins for 50 and 100 mg/kg dose range and 30 mins for 200 mg/kg dose range. The results suggest a potential benefit of M indica methanolic extract in treating conditions associated with fever, inflammation and pain. These properties might be adduced to the presence of the phytoconstituents

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms

Gastroentero-pancreatic Neuroendocrine Neoplasms (GEP-NENs) are a diverse group of rare tumors that arise from neuroendocrine cells in the gastrointestinal tract and pancreas, and they can vary significantly in terms of clinical behavior and prognosis. Immunotherapy, particularly immune checkpoint inhibitors, has shown remarkable success in various malignancies by harnessing the body’s immune system to target and eliminate cancer cells. Immune checkpoint inhibitor clinical studies in GEP-NENs have yielded promising outcomes, particularly in individuals with advanced and refractory disease. Objective responses and disease stabilization have been observed in some cases, even in those previously unresponsive to traditional treatments like chemotherapy or targeted therapies. However, it’s important to note that the efficacy of immunotherapy in GEP-NENs can vary widely depending on tumor characteristics, the immune microenvironment, and patient factors. As such, identifying predictive biomarkers to select the most suitable patients for immunotherapy remains an ongoing challenge. Immunotherapy has considerable potential for treating GEP-NENs, but research is still in its early stages. Several combinations are being explored to enhance the effectiveness of immunotherapy and improve the outcomes of treatment, such as combining immunotherapy with other targeted therapies or chemotherapy

A Comparative Study of Generalized & Classical Absorption Coefficients in D-Region at Udaipur

5-8A study or the ratio γ or the absorption coefficients (K)given by the Sen-Wyller (S-W) generalized theory and the Appleton-Hartree (A-H) classical theory has been made for the D-region for various working frequencies. An empirical relation for γ has been proposed as a function of height and working frequency, which would help one to compute the generalized absorption coefficients, simply multiplying the values of K calculated from the A-H theory by γ. It has been found that γ varies nearly from 1to 2.5 in the height range of 70-85 km and remains 2.5 for heights above 85 km. The total non-dedicative absorptions at various working frequencies have also been computed graphically

Lifestyle Factors in Cancer Survivorship: Where We Are and Where We Are Headed

Advances in early detection and curative therapies have led to an increased number of cancer survivors over the last twenty years. With this population comes the need to evaluate the late and long term effects of cancer treatment and develop recommendations about how to optimally care for these survivors. Lifestyle factors (diet, body weight, physical activity, and smoking) have been linked to a higher risk of many medical comorbidities (cardiovascular, metabolic, etc.). There is increasing evidence linking these factors to the risk of developing cancer and likely cancer-related outcomes. This link has been studied extensively in common cancers like breast, colon, prostate, and lung cancers through observational studies and is now being prospectively evaluated in interventional studies. Realizing that survivors are highly motivated to improve their overall health after a diagnosis of cancer, healthy lifestyle recommendations from oncology providers can serve as a strong tool to motivate survivors to adopt health behavior changes. Our article aims to review the evidence that links lifestyle factors to cancer outcomes and provides clinical recommendations for cancer survivors

Variation of Apparent Ionospheric Height with Frequency & Observed Multiple Reflections

136-137A theoretical analysis of the effect of the apparent height gradient dh'/df in the ionosphere on the shape of the reflected pulse has been made. It has been shown that when the gradient dh'/df is high, the pulse would normally be split into two. It has been further shown that the observed four split echoes may be the result of such a gradient in the electron density in the ionosphere, when the working frequency is near the critical frequency of the region