Synthesis of a New Series of Quinolinoxymethylcoumarins as Potent Anticancer Agents

4-Bromomethylcoumarins (1a-f) were reacted with 8-hydroxyquinoline to yield quinolinoxymethylcoumarins (2a-f). The structure of all the synthesized compounds were confirmed by spectral studies and screened for their anticancer activities against Dalton’s Ascitic lymphoma (DAL) and Ehrlich Ascites Carcinoma (EAC) cell lines.  Out of these, compound (2b) (R = 6-OMe) was found to be the most potent cytotoxic compound against DAL and EAC cell lines.           

InCl3-​assisted synthesis and cytotoxic studies of some novel heteroaryl thiazoles

Heteroaryl thiazoles were synthesized by the Hantzsch reaction of various α-​bromoketones with aryl thioureas using InCl3 as a catalyst in a shorter reaction time. The synthesized compds. were characterized and screened for their in-​vitro cytotoxic activity against DAL and EAC cells. Compd. I was found to be most effective against DAL cell lines with IC50 value of 15.76 μg​/mL. Compd. II was found to be most effective against EAC cells with IC50 value of 28.73 μg​/mL

<i>Mentha arvensis</i> essential oil suppressed airway changes induced by histamine and ovalbumin in experimental animals

<p>The present investigation aimed to evaluate the activity of the essential oil of <i>Mentha arvensis</i> L. on exogenously induced bronchoconstriction in experimental animals. The anti-asthmatic effect of <i>M. arvensis</i> essential oil (MAEO) was studied using histamine aerosol-induced bronchoconstriction in guinea pigs and ovalbumin (OVA) sensitised albino mice. Treatment with <i>M. arvensis</i> oil significantly (<i>p</i> < 0.001) increased the time of preconvulsive dyspnoea in histamine-induced guinea pigs. Oral treatment of MAEO significantly (<i>p</i> < 0.001) decreased absolute eosinophil count, serum level of IgE and the number of eosinophils, neutrophils in BALF. Histopathological examination of lungs showed that essential oil rescinded bronchial asthma. The present investigation provides evidence that MAEO relaxes bronchial smooth muscles and suppressed immunological response to OVA.</p