InCl3-​assisted synthesis and cytotoxic studies of some novel heteroaryl thiazoles

Boggavarapu Chand, S.G.; Boregowda Puttaraju, K.; Kalegowda Shivashankar, .; Ramamohan Reddy, K.; Rasal Vijaykumar, P.; Venkata Vivek, P.N.

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InCl3-assisted synthesis and cytotoxic studies of some novel heteroaryl thiazoles

Authors: S.G. Boggavarapu Chand
K. Boregowda Puttaraju
. Kalegowda Shivashankar
K. Ramamohan Reddy
P. Rasal Vijaykumar
P.N. Venkata Vivek
Publication date: 1 September 2013
Publisher: International Journal of Chemical and Pharmaceutical Sciences

Abstract

Heteroaryl thiazoles were synthesized by the Hantzsch reaction of various α-bromoketones with aryl thioureas using InCl3 as a catalyst in a shorter reaction time. The synthesized compds. were characterized and screened for their in-vitro cytotoxic activity against DAL and EAC cells. Compd. I was found to be most effective against DAL cell lines with IC50 value of 15.76 μg/mL. Compd. II was found to be most effective against EAC cells with IC50 value of 28.73 μg/mL