Treatment of diaphyseal fractures of tibia with intramedullary interlocking nail

Background: The tibia, or shinbone, is the most commonly fractured long bone in the body. A tibial shaft fracture occurs along the length of the bone, below the knee and above the ankle. It typically takes a major force to cause this type of broken leg. Motor vehicle collisions, for example, are a common cause of tibial shaft fractures. In many tibia fractures, the smaller bone in the lower leg (fibula) is broken as well. The objective was to study fracture healing and union rates with closed intra-medullary interlocking nailing.Methods: Patients of both sexes belonging to adult age group presenting with fracture tibia to Orthopedic Department, Vydehi Institute of Medical Sciences, of are admitted from January 2015 to December 2015.Results: In the present study maximum number of patients belongs to 18 to 27 years age group (18 cases) followed by 28 to 37 years age group (15 cases), maximum number of patients sustained tibia fracture due to RTA (38 cases) followed by fall (12 cases), maximum number of patients sustained simple tibia fracture (32 cases), followed by type 2 compound tibia fracture (13 cases) and 36 patients had excellent functional results and 8 patients had good functional outcome, while only 4 patients had fair functional outcome.Conclusions: IM rods are secured within the bone by screws both above and below the fracture. The metal screws and the rod can be removed if they cause problems, but can also be left in place for life. Tibial rodding provides excellent fixation and alignment of the bones

Surgical management of diaphyseal fracture of femur with closed intramedullary interlocking nail

Background: A femoral fracture is a bone fracture that involves the femur. They are typically sustained in high-impact trauma, such as car crashes, due to the large amount of force needed to break the bone. The objective of the study was to evaluate the functional outcome of fractures of the shaft of the femur treated with closed intra-medullary interlocking nailing.Methods: The present study was carried out between June 2015 to May 2016 in Orthopedic Department, Vydehi institute of medical sciences and research centre, Bengaluru. Antegrade nailing using the standard intramedullary interlocking nail was performed on 50 cases who presented with shaft fractures of the femur.Results: In the present study maximum number of patients belongs to 18 to 27 years age group (24 cases) followed by 28 to 37 years age group (12 cases), maximum number of patients sustained femur fracture due to RTA (42 cases) followed by fall (08 cases), maximum number of patients sustained closed/simple femur fracture (40 cases), followed by open / compound tibia fracture (10 cases), 32 patients had excellent functional results and 10 patients had good functional outcome, while only 5 patients had fair functional outcome.Conclusions: A femur fracture is always considered a medical emergency requiring immediate evaluation and treatment in a hospital. The treatment is largely dependent on the location of the fracture and the pattern and extent of the break

Simulation Results of Double Forward Converter

This work aims to find a better forward converter for DC to DC conversion.Simulation of double forward converter in SMPS system is discussed in this paper. Aforward converter with RCD snubber to synchronous rectifier and/or to current doubleris also discussed. The evolution of the forward converter is first reviewed in a tutorialfashion. Performance parameters are discussed including operating principle, voltageconversion ratio, efficiency, device stress, small-signal dynamics, noise and EMI. Itscircuit operation and its performance characteristics of the forward converter with RCDsnubber and double forward converter are described and the simulation results arepresented

Induction of somatic embryogenesis in different varieties of sugarcane (Saccharam officinarum L.)

This investigation for the first time highlights TDZ induced callus formation, somatic embryogenesis and plant regeneration using leaf explants of different varieties (Co94032,CoC671, Co86032, SNK754, SNK61 and SNK44) of sugarcane (Saccharam officinarum). Leaf explants cultured on the full strength inorganic salts Murashige and Skoog (1962) basal medium supplemented with 4.52 μM 2, 4-D and 4.54 μM TDZ induced embryogenic tissue after 3-4 weeks. The percentage of somatic embryogenesis was not similar in all the tested varieties of sugarcane. This study indicates a high embryogenic potential of leaf explants of tested sugarcane varieties, and also opened up the possibility for large-scale clonal propagation of sugarcane for the genetic improvement programmes

Crystallographic Stability of Metastable Phase Formed by Containerless Processing in REFeO3 (RE: Rare-Earth Element)

Undercooling a melt often facilitates a metastable phase to nucleate preferentially. Although the classical nucleation theory shows that the most critical factor for forming a metastable phase is the interface free energy, the crystallographic stability is also indispensable for the phase to be frozen at ambient temperature. In compound materials such as oxides, authors have suggested that the decisive factors for forming a critical nucleus are not only the free energy difference but also the difference of the entropy of fusion between stable and metastable phases. In the present study, using REFeO3 (RE: rare-earth element) as a model material, we investigate the formation of a metastable phase from undercooled melts with respect to the competitive nucleation and crystallographical stabilities of both phases

Laboratory Column flotation studies for reduction of alumina and silica in iron ore slimes of an operating plant

A typical iron ore washing plant for treating iron ore fines (<10 mm) consist of sizing of the ore by dry / wet screening, washing, classification by screw classifiers followed by single or multi-stage hydrocycloning of screw classifiers overflow. The underflow of the hydrocyclones forms the concentrate which is suitable for pellets making. Since the cut-point of hydrocyclones is usually at 20 µm or less, relatively lower diameter cyclones in a cluster with parallel feeding are used. This is found to, often, result in choking of the spigots, at times, by extraneous material reporting along with the slurry. It is observed to lead to sub-optimum performance of the cyclones with loss of iron values into cyclone overflow and thereafter into tailings. Analysis of the data of an operating beneficiation plant (Beneficiation plant - 1) of M/s Jindal South West (JSW) Steel Limited, Karnataka, India over a period of one year indicated that weight recovery of the concentrate from two-stage hydrocycloning was 45.9% (with respect to feed to the cyclones) and assaying 63.43% Fe, 4.43% SiO2 and 2.23% Al2O3. Considering the fineness of the slimes (d80: 40.5 µm), generated as screw classifier overflow, flotation is thought to be better alternative vis-à-vis hydrocyclones to recover iron values from it. The present study aims at improving the recovery of the iron values from the screw classifier overflow by adopting reverse cationic column flotation technology. After selecting a suitable collector, process parameters like collector and depressant dosages are optimized by statistically designed experiments on a Denver D12 flotation cell. Later, the effect of important operating parameters of flotation column like air flow-rate, froth depth and wash water on the separation process is studied and optimized. It was established that a typical screw classifier overflow analyzing 60.43% Fe, 6.88% SiO2 and 3.26% Al2O3 could be improved to 63.30% Fe, 4.04% SiO2 and 2.32% Al2O3 with 59.10% weight and 61.70% Fe recovery. This is an improvement of 29% in weight recovery of the concentrate at equivalent metallurgy compared to what is being obtained, by two-stage cycloning

Inhibition of free radical activity by dual PPAR α and PPAR γ agonist using analytical assay methods

Background: Overproduction of free radicals involved in the pathology of a wide variety of clinical disorders. Poor glycaemic control in diabetic people leads to free radical production responsible for diabetic related complications. Antioxidants produces resistance against the oxidative stress by scavenging free radicals may useful in treating diabetic related complications. Saroglitazar is a newer antidiabetic drug act on dual Peroxisome Proliferator Receptor Agonist α (PPAR α) and PPAR γ agonist with protection effect on Diabetes mellitus induced lipid dystrophy. Our study was done to evaluate the in vitro antioxidant effect Saroglitazar by 1, 1 Diphenyl 2 Picryl hydrazide (DPPH) and Nitric Oxide (NO) method.Methods: In this study, we demonstrated invitro antioxidant activity by using 10 mg/dl stock solutions of Saroglitazar. DPPH and NO free radical scavenging test were done for different concentration of Saroglitazar.Results: Saroglitazar showed concentration dependent free radical scavenging activity in DPPH assay. In DPPH assay at higher concentration 1000ug concentration showed 49.18% free radical scavenging activity. At lower concentration 10ug showed 17.18% free radical scavenging activity. NO scavenging activity at lower concentration 100ug showed 55.15% activity. But the higher concentration (1000ug) only slight increase in 60.15% activity.Conclusions: Thus Saroglitazar invitro antioxidant analysis proved that it is a potent antioxidant

Antipsoriatic activity of Cassia auriculata L. flowers in Freund’s adjuvantformaldehyde induced animal model

The plant Cassia auriculata L. belonging to the family Caesalpiniaceae (Leguminosae) used in the Ayurvedic system of medicine for the treatment of diabetes, ulcers, leprosy, conjunctivitis, liver and skin diseases. The present study aimed to evaluate the antipsoriatic effect of the ointments 0.5 and 1.0% (w/w) containing ethanol extract of the flowers of C. auriculata using complete Freund's adjuvant (CFA) and induced animal model and also evaluated for its physical parameters. Antipsoriatic effect of 0.5 and 1.0% (w/w) ointments was evaluated by the phenotypic features (redness, erythema, and scales) in terms of psoriasis severity index (PSI) and histological features (epidermal thickness and degree of orthokeratosis). Evaluation of physical parameters for the prepared ointments showed satisfactory results with an acceptable condition of consistency for application. 0.5 and 1.0% (w/w) ointments treated animals showed a significant (*P &lt;0.05) increase in the orthokeratinocyte layer and a significant (**P &lt;0.01) reduction in the epidermal layer of skin treated with 1.0% (w/w) ointment with a progressive reduction (**P &lt;0.01) in the severity of psoriatic lesions (erythema, redness, and scales) from day 7 to 21st day. The present investigations revealed that the flowers of Cassia auriculata possess antipsoriatic activity, confirming their traditional use in skin disorders