Adult-onset Still’s disease with secondary hemophagocytic lymphohistiocytosis: a case report

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation causing multi-organ dysfunction. HLH can be inherited genetically, but can also be secondary to infections, malignancy, immunosuppression, and autoimmune conditions. Adult-onset Still’s disease (AOSD) is an autoimmune disorder characterized by fevers, arthritis, and an evanescent rash. It can rarely predispose patients to HLH. Herein, we report a case of a 20-year-old male patient who presented with fever, joint pain, and rash for 1 month. On evaluation, he was diagnosed as a case of AOSD complicated with secondary HLH. A 23-year-old male, with no significant past medical history and family history, presented to our emergency department with complaints of fever with rash for the last 1 month. He had intermittent high-grade fever with chills, which was associated with evanescent rash involving the trunk and proximal upper limbs. There was no history of joint pain, cough, sore throat, burning micturition, or weight loss. On examination, the patient was conscious and oriented with a temperature of 101 °F, pulse rate of 100/min, blood pressure of 120/84 mmHg, and SpO2 of 98% on room air. Physical examination revealed salmon-colored maculopapular rash, cervical lymphadenopathy, and mild splenomegaly. The rest of the physical examination was unremarkable. Lab investigations revealed pancytopenia, transaminitis, elevated CRP with low ESR, highly elevated ferritin, elevated LDH, hypofibrinogenemia, and sterile blood and urine cultures. ANA by ELISA, rheumatoid factor, IGRA, dengue IgM, rapid malaria Ag, typhoid IgM, Leptospira IgM and scrub IgM were reported negative. The patient met the diagnostic criteria for AOSD and HLH, and a diagnosis of HLH secondary to AOSD was made. He was given pulse iv methylprednisolone for 5 days, His general condition improved over the week. Then he was switched to oral prednisolone 60 mg once daily. There were no more episodes of fever, and he was discharged after one week on a tapering dose of steroids. AOSD is a rare autoinflammatory condition which often presents as a diagnostic challenge. A high index of suspicion is important for the diagnosis of HLH, and prompt initiation of treatment is of utmost importance, as it is a rapidly progressive life-threatening condition

Sustainable Agroecosystems for Livelihood Security in Indian Himalayas

Agroforestry systems are an age-old practice in the Indian Himalayan region. Agroforestry deals with the combination of tree species with crop plants, fisheries, animals, bee keeping, and so on, and it is based on the principle of optimum utilization of land. Agrihorticulture, silvihorticulture, hortipastoral, and silvipastoral systems are diversified land use options for agroforestry in the hill region. The study was conducted at experimental farm Hawalbagh (29o36′N and 79o 40′ E, 1250 m amsl) of Vivekananda Parvatiya Krishi Anusandhan Sansthan, Almora, India. Study in an agri-horti system revealed that ragi (Eluesine coracana) and soybean (Glysine max) during kharif (rainy season) and wheat (Triticum estivum) and lentil (Lens esculenta) during rabi (winter season) can be grown successfully with pecan nut (Carya illinoinensis) tree without significant reduction in the yield of the crop. However, grain yield of these crops was numerically higher in the field without pecan nut tree. In fruit-based agri-horti system four fruit crops, hill lemon (Citrus limon), pear (Pyrus communis), plum (Prunus domestica), and apricot (Prunus armeniaca) were planted with soybean in kharif and dual purpose wheat during rabi season. During initial years, no significant effect on grain yield was observed with the presence of different fruit trees. Green forage yield varied from 4600 to 5900 kg/ha in different treatments. In different treatments, ginger (Zingiber officinale) and turmeric (Curcuma longa), turmeric and taro (Colocasia esculenta), and two varieties of turmeric (Pant Pitabh and Swarna) were grown under Grewia optiva, Quercus leucotrichophora, Bauhinia variegata, and Celtis australis. Turmeric and ginger produced significantly higher yield (12.04 and 7.99 t/ha) under oak. The highest rhizome yield was obtained under Quercus leucotrichophora (11,738 kg/ha) followed by Bauhinia variegata. Pant Pitabh gave significantly higher yield (10,860 kg/ha) than swarna. Improved systems with five tree species, that is, Grewia optiva, Quercus leucotrichophora, Bauhinia retusa, Melia azedarach, and Morus alba and four grasses, that is, Setaria kazugulla, Setaria nandi, Congo signal, and Broad leaf paspalum (Paspalum spp.) were tested under the silvipastoral system. Quercus leucotrichophora yielded (10,675 kg/ha) significantly higher green biomass than others, and the lowest green biomass was harvested from Grewia optiva. Among grasses, Setaria nandi produced the highest green forage (6234 kg/ha). Thus, in hilly terrain, planting of interspatial woody perennials, with least negative influences on the agronomic crops, seems productive in agroforestry system for settled farming. Therefore, agroforestry is a set of land use alternative, which if developed for resource poor farmers, can provide increased values and reduced risks and it should be made more popular in the rural areas

A study of neonatal and maternal outcomes of asthma during pregnancy

Background: Asthma is a common problem all around the world with variable prevalence ranging from 1%–18% in different age and geographical distribution. There are proximately 300 million affected individuals. There are growing prevalence and morbidity, due to asthma associated with pregnancy. The course of asthma in pregnancy is unpredictable.Methods: 2400 consecutive pregnant women attending the antenatal clinic of S.P. Medical College and AG of Hospitals, Bikaner, were screened using asthma questionnaire translated in Hindi based on the questionnaire developed for International Union against Tuberculosis and Lung Disease. 52 patients diagnosed as asthma were subjected for PFT and classified according to clinical severity as per GINA guidelines, 2006. All subjects were followed till delivery and postpartum charts reviewed to see neonate and maternal outcome.Results: The prevalence of asthma during pregnancy was 2.1%, among them, 25 (48.1%) were categorized as having intermittent asthma, 6 (11.5%) with mild persistent asthma, 10 (19.2%) with moderate persistent asthma and 11 (21.2%) having severe persistent asthma. During the course of pregnancy, 36% had no change in the symptomatology, while (32.5%) experienced improvement and (32.5%) of worsening of asthma. 22 (42.31%) women were newly diagnosed during our study. There was no significant adverse maternal and fetal outcome in asthmatic group compared to control.Conclusions: Asthma is an under diagnosed and under treated disorder, especially during pregnancy and overall morbidity of asthma among women & neonates does not change during pregnancy.

Integrated effect of bio-organics with chemical fertilizer on growth, yield and quality of cabbage (Brassica oleracea var capitata)

This experiment focused on the effects of Pseudomonas fluorescens and humic acid in combination with three different levels of fertilizers on growth, yield and quality traits of Brassica oleracea L. Results indicated that treatments comprising 100% recommended fertilizers package coupled with seedling treated with Pseudomonas fluorescens and humic acid caused significantly higher plant height, dry matter in leaves (head), higher number of non-wrapper leaves and head yield (54.38 tonnes/ha) over 50% recommended dose of fertilizer with Pseudomonas fluorescens applied. Treatment 50% recommended dose of fertilizer applied with Pseudomonas fluorescens and humic acid was at par with 100% recommended dose of fertilizer alone. Total carbohydrate content in head (40.46%) was significantly higher with use of 100% recommended dose of fertilizer with Pseudomonas fluorescens and humic acid. Maximum protein content (18.54%) was noticed with application of 100% recommended dose of fertilizer with Pseudomonas fluorescens and humic acid that was 10.90% higher than recommended dose of fertilizer alone. Fibre content in head was improved remarkably with the use of Pseudomonas fluorescens and humic acid. Significantly higher content of ascorbic acid (34.51 mg/100 g) in head was also registered with application of 100% recommended dose of fertilizer with Pseudomonas fluorescens and humic acid

Evaluation of digital elevation model in hilly region of Uttarakhand: A case study of experimental farm Hawalbagh

Not AvailableDigital Elevation Model (DEM) is used to display terrestrial information on map. Moreover, DEMs are often used in geographic information systems (GIS), and serve as a basis for generation of relief map. The present study was conducted to evaluate the google earth (GE) derived DEM with three established open source DEMs such as, shuttle radar topographic mission (SRTM) DEM, advanced space borne thermal emission and reflection radiometer (ASTER) DEM and advanced land observing satellite phased array type l−band synthetic aperture radar (ALOS PALSAR) DEM. The study area of present research is experimental farm, Hawalbagh of the ICAR− Vivekananda Parvatiya Krishi Anusandhan Sansthan (VPKAS), Almora, India which lies in middle Himalayas using online tool (GPS visualizer). The accuracy statistics were evaluated using 100 points in the study area having varying topography with three DEMs such as, SRTM DEM, ASTER DEM and ALOS PALSAR DEM. The result showed that google earth data was positively correlated with all established 2 DEM with r value of 0.88 for SRTM, 0.92 for ALOS PALSAR Dem and 0.83 for ASTER DEM. The result showed that the accuracies for the google earth derived DEM is suitable for hydrological and other water resources modelling.Not Availabl

Do Human Resources have more Value than the Cost incurred on them by the Organisation? An Empirical Analysis of Infosys Ltd. using Contribution-Based Model

Employees always play an important role in the service sector. For this study, we have selected Infosys Ltd. as a leading company in the IT sector. The study’s objective is to analyze the expenditure incurred by Infosys Ltd. on their employees and the value of employees’ contribution to Infosys Ltd. using the Human Resources Information System (HRIS), a contribution-based model that consists of 13 variables. Out of the 13 variables, 09 variables are monetary. We have collected data from the latest financial reports of Infosys Ltd. and the Reserve Bank of India’s database for eight monetary variables. Four out of 13 variables are non-monetary for which data have been collected with the help of a standardized questionnaire using 5 points Likert scale. Based on the responses received from 119 employees of Infosys Ltd. and by analyzing data we conclude at both the individual and organization levels that there is a difference between the expenditure incurred by Infosys Ltd. on their employees in total and the Value of all employees’ contribution as an individual and as a group towards Infosys Ltd. This means that the employees’ contributions both individually and collectively are much more than the cost incurred by the organization

Response surface optimization for development of Dragon fruit based ready to serve drink

Dragon fruit based ready to serve drink (RTS) was formulated using dragon fruit (60-80% v/v), grape juice (0-10% v/v) and sugar syrup (2-6% v/v). The juice concentrations were optimized using response surface methodology (RSM) following box-behnken design (BBD) for obtaining blended RTS drink with higher functional and nutritional characteristics like total soluble solid (TSS), titratable acidity, ascorbic acid content, total phenol content, colour and sensory evaluation. Results showed that there was significant (P<0.01) effect of incorporating grape juice and sugar syrup which further improved the organoleptic properties of the blended RTS.Optimum juice percentages obtained for the best blend formulation were,dragon fruit (70%), grape juice (5%) and sugar syrup (3%), respectively. The beverage was observed to be acceptable in terms of its nutritional value and overall acceptability

Climatic Variation and Its Impacts on Yield and Water Requirement of Crops in Indian Central Himalaya

Climate is most important factor affecting agriculture, and issues related to climate and its implications have attracted attention of policy makers globally. The farm sector, particularly marginal ecosystems in mountains are vulnerable because of unpredictable variation and severe sink limitations. Efforts to impart resilience to farm and its allied sector are an urgent need. The climatic parameters play very important role to determine type of crops, cattle rearing and the life style adopted by the people. Moreover, weather has a significant impact on crop growth and development. Weather plays a vital role and affects the production and productivity of the crops. According to an estimate, weather contributes 67% variation in productivity and rest of the factors (soil, nutrient and management practices etc.) accounts for 33%. Therefore, there is a need of in-depth analysis of each meteorological parameters and identification of their trend over the years in order to identify and adapt suitable agriculture practices, better adaptable crops, varieties and their duration, time of field preparation, sowing time and irrigation as per the climatic conditions of the region. This will lead farming community to plan strategies of agriculture operation to obtain optimum yield. The climatic data from the meteorological observatory of ICAR-VPKAS, Hawalbagh located at mid hill condition (1250 m amsl) were analyzed for different periods (annual, seasonal, monthly, weekly). It was revealed that rainfall is decreasing over the years but significant (P < 0.05) decrease was recorded at mid hills. The maximum temperature is increasing significantly (P < 0.05) during post-monsoon and winter season however decreasing in monsoon season whereas minimum temperature is decreasing round the year. These changes in rainfall and temperatures are affecting production and productivity of the crops, as hills are largely rainfed. In terms of crop water demand, there is no need to apply irrigation during the rainy season except the transplanted rice. However, during the winter season as there is more than 60% of water deficit to irrigate the crops. The proper understanding of climate is necessary to bring sustainability in hill agriculture by adjusting crop sowing window and other operations as per suitability of the climate

Potential Role of Plant Growth Regulators in Administering Crucial Processes Against Abiotic Stresses

Plant growth regulators are naturally biosynthesized chemicals in plants that influence physiological processes. Their synthetic analogous trigger numerous biochemical and physiological processes involved in the growth and development of plants. Nowadays, due to changing climatic scenario, numerous biotic and abiotic stresses hamper seed germination, seedling growth, and plant development leading to a decline in biological and economic yields. However, plant growth regulators (PGRs) can potentially play a fundamental role in regulating plant responses to various abiotic stresses and hence, contribute to plant adaptation under adverse environments. The major effects of abiotic stresses are growth and yield disturbance, and both these effects are directly overseen by the PGRs. Different types of PGRs such as abscisic acid (ABA), salicylic acid (SA), ethylene (ET), and jasmonates (JAs) are connected to boosting the response of plants to multiple stresses. In contrast, PGRs including cytokinins (CKs), gibberellins (GAs), auxin, and relatively novel PGRs such as strigolactones (SLs), and brassinosteroids (BRs) are involved in plant growth and development under normal and stressful environmental conditions. Besides, polyamines and nitric oxide (NO), although not considered as phytohormones, have been included in the current review due to their involvement in the regulation of several plant processes and stress responses. These PGRs are crucial for regulating stress adaptation through the modulates physiological, biochemical, and molecular processes and activation of the defense system, upregulating of transcript levels, transcription factors, metabolism genes, and stress proteins at cellular levels. The current review presents an acumen of the recent progress made on different PGRs to improve plant tolerance to abiotic stress such as heat, drought, salinity, and flood. Moreover, it highlights the research gaps on underlying mechanisms of PGRs biosynthesis under stressed conditions and their potential roles in imparting tolerance against adverse effects of suboptimal growth conditions.Fil: Sabagh, Ayman EL. Kafrelsheikh University; EgiptoFil: Mbarki, Sonia. National Institute Of Research In Rural Engineering; TúnezFil: Hossain, Akbar. Bangladesh Agricultural Research Institute; BangladeshFil: Iqbal, Muhammad Aamir. University Of Poonch Rawalakot; PakistánFil: Islam, Mohammad Sohidul. Hajee Mohammad Danesh And Technology University; BangladeshFil: Raza, Ali. Fujian Agriculture And Forestry University; ChinaFil: Llanes, Analia Susana. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Investigaciones Agrobiotecnologicas. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Investigaciones Agrobiotecnologicas.; ArgentinaFil: Reginato, Mariana Andrea. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Investigaciones Agrobiotecnologicas. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Investigaciones Agrobiotecnologicas.; ArgentinaFil: Rahman, Md Atikur. Grassland And Forage Division National Institute; Corea del SurFil: Mahboob, Wajid. Nuclear Institute Of Agriculture,; PakistánFil: Singhal, Rajesh Kumar. Indian Council Of Agricultural Research; IndiaFil: Kumari, Arpna. Guru Nanak Dev University; IndiaFil: Rajendran, Arvind. Vellore Institute Of Technology; IndiaFil: Wasaya, Allah. Bahauddin Zakariya University; PakistánFil: Javed, Talha. Fujian Agriculture And Forestry University; JapónFil: Shabbir, Rubab. University Of Poonch Rawalakot; PakistánFil: Rahim, Junaid. University Of Çukurova; PakistánFil: Barutçular, Celaleddin. Institute Of Crop Science And Resource Conservation; AlemaniaFil: Habib Ur Rahman, Muhammad. Sichuan Agricultural University; ChinaFil: Raza, Muhammad Ali. Sichuan Agricultural University; ChinaFil: Ratnasekera, Disna. University Of Ruhuna; Sri LankaFil: Konuskan l, Ömer. Mustafa Kemal University; TurquíaFil: Hossain, Mohammad Anwar. Bangladesh Agricultural Research Institute; BangladeshFil: Meena, Vijay Singh. Indian Council Of Agricultural Research; IndiaFil: Ahmed, Sharif. Bangladesh Agricultural Research Institute; BangladeshFil: Ahmad, Zahoor. Bangladesh Wheat And Maize Research Institute; BangladeshFil: Mubeen, Muhammad. Sichuan Agricultural University; ChinaFil: Singh, Kulvir. Punjab Agricultural University; IndiaFil: Skalicky, Milan. Czech University Of Life Sciences Prague; República ChecaFil: Brestic, Marian. Slovak University Of Agriculture; EslovaquiaFil: Sytar, Oksana. Slovak University Of Agriculture; EsloveniaFil: Karademir, Emine. Siirt University; TurquíaFil: Karademir, Cetin. Siirt University; TurquíaFil: Erman, Murat. Siirt University; TurquíaFil: Farooq, Muhammad. College Of Agricultural And Marine Sciences Sultan; Omá