Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are important factors modulating these pathways. In addition, live reporters reveal that Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process

On the Effective Action of Noncommutative Yang-Mills Theory

We compute here the Yang-Mills effective action on Moyal space by integrating over the scalar fields in a noncommutative scalar field theory with harmonic term, minimally coupled to an external gauge potential. We also explain the special regularisation scheme chosen here and give some links to the Schwinger parametric representation. Finally, we discuss the results obtained: a noncommutative possibly renormalisable Yang-Mills theory.Comment: 19 pages, 6 figures. At the occasion of the "International Conference on Noncommutative Geometry and Physics", April 2007, Orsay (France). To appear in J. Phys. Conf. Se

Overview of the parametric representation of renormalizable non-commutative field theory

We review here the parametric representation of Feynman amplitudes of renormalizable non-commutative quantum field models.Comment: 10 pages, 3 figures, to be published in "Journal of Physics: Conference Series

Construction of chromosome segmen substitution lines in peanut (Arachis hypogaea L.) using a wild synthetic and QTL mapping for plant morphology.

Made available in DSpace on 2018-07-01T01:24:40Z (GMT). No. of bitstreams: 1 journal.pone.0048642.PDF: 1048747 bytes, checksum: 027bf011c3b68a926d1012744b0ec4b3 (MD5) Previous issue date: 2013-02-27bitstream/item/179310/1/journal.pone.0048642.PD

Comparative efficacy of two fipronil spot-on formulations against experimental tick infestations (Ixodes ricinus) in dogs

A parallel-group-design, randomized, unicentre and blinded controlled study was undertaken to assess the efficacy of a new fipronil-based spot-on formulation applied once to dogs against experimental Ixodes ricinus infestations. Six dogs served as negative controls (group 1), six dogs served as positive controls (group 2) receiving the original fipronil spot-on (Frontline® spot-on Dog, Merial) at a dosage of 0.67 mL for a dog weighing from 2 to 10 kg and 1.34 mL for a dog weighing from 10.1 to 20 kg and six dogs were treated with a 10% w/v fipronil-based spot-on solution (Effipro® Spot-on, Virbac SA) at an identical dosage (group 3, 0.67 mL for a dog weighing from 2 to 10 kg and 1.34 mL for a dog weighing from 10.1 to 20 kg). Each dog was sedated and subsequently infested with 50 unfed adult I. ricinus on days −7, −2, 7, 14, 21, 28 and 35. Forty-eight hours after the treatment and 48 h after each challenge (days −5, 2, 9, 16, 23, 30 and 37), the population of the remaining ticks was assessed for each animal. Geometric mean tick counts obtained were reduced by 99% and 94% on day 2 in groups 2 and 3, respectively, compared to the negative control group. Dogs were protected from re-infestations with an efficacy of >90% for 3 weeks in group 2 and for 5 weeks in group 3. Both 10% w/v fipronil-based spot-on solutions, despite different vehicles, were equally able to eradicate tick infestation, to prevent new infestations and were equally well tolerated

Star-spot activity, orbital obliquity, transmission spectrum, physical properties, and TTVs of the HATS-2 planetary system

Our aim in this paper is to refine the orbital and physical parameters of the HATS-2 planetary system and study transit timing variations and atmospheric composition thanks to transit observations that span more than ten years and that were collected using different instruments and pass-band filters. We also investigate the orbital alignment of the system by studying the anomalies in the transit light curves induced by starspots on the photosphere of the parent star. We analysed new transit events from both ground-based telescopes and NASA's TESS mission. Anomalies were detected in most of the light curves and modelled as starspots occulted by the planet during transit events. We fitted the clean and symmetric light curves with the JKTEBOP code and those affected by anomalies with the PRISM+GEMC codes to simultaneously model the photometric parameters of the transits and the position, size, and contrast of each starspot. We found consistency between the values we found for the physical and orbital parameters and those from the discovery paper and ATLAS9 stellar atmospherical models. We identified different sets of consecutive starspot-crossing events that temporally occurred in less than five days. Under the hypothesis that we are dealing with the same starspots, occulted twice by the planet during two consecutive transits, we estimated the rotational period of the parent star and, in turn the projected and the true orbital obliquity of the planet. We find that the system is well aligned. We identified the possible presence of transit timing variations in the system, which can be caused by tidal orbital decay, and we derived a low-resolution transmission spectrum.Comment: 23 pages, 21 figures, Accepted for publication in Astronomy & Astrophysic

Climate change mitigation and adaptation in the land use sector: from complementarity to synergy

Currently, mitigation and adaptation measures are handled separately, due to differences in priorities for the measures and segregated planning and implementation policies at international and national levels. There is a growing argument that synergistic approaches to adaptation and mitigation could bring substantial benefits at multiple scales in the land use sector. Nonetheless, efforts to implement synergies between adaptation and mitigation measures are rare due to the weak conceptual framing of the approach and constraining policy issues. In this paper, we explore the attributes of synergy and the necessary enabling conditions and discuss, as an example, experience with the Ngitili system in Tanzania that serves both adaptation and mitigation functions. An in-depth look into the current practices suggests that more emphasis is laid on complementarity—i.e., mitigation projects providing adaptation co-benefits and vice versa rather than on synergy. Unlike complementarity, synergy should emphasize functionally sustainable landscape systems in which adaptation and mitigation are optimized as part of multiple functions. We argue that the current practice of seeking co-benefits (complementarity) is a necessary but insufficient step toward addressing synergy. Moving forward from complementarity will require a paradigm shift from current compartmentalization between mitigation and adaptation to systems thinking at landscape scale. However, enabling policy, institutional, and investment conditions need to be developed at global, national, and local levels to achieve synergistic goals