Love songs and serenades: a theoretical review of music and romantic relationships

In this theoretical review, we examine how the roles of music in mate choice and social bonding are expressed in romantic relationships. Darwin’s Descent of Man originally proposed the idea that musicality might have evolved as a sexually selected trait. This proposition, coupled with the portrayal of popular musicians as sex symbols and the prevalence of love-themed lyrics in music, suggests a possible link between music and attraction. However, recent scientific exploration of the evolutionary functions of music has predominantly focused on theories of social bonding and group signaling, with limited research addressing the sexual selection hypothesis. We identify two distinct types of music-making for these different functions: music for attraction, which would be virtuosic in nature to display physical and cognitive fitness to potential mates; and music for connection, which would facilitate synchrony between partners and likely engage the same reward mechanisms seen in the general synchrony-bonding effect, enhancing perceived interpersonal intimacy as a facet of love. Linking these two musical functions to social psychological theories of relationship development and the components of love, we present a model that outlines the potential roles of music in romantic relationships, from initial attraction to ongoing relationship maintenance. In addition to synthesizing the existing literature, our model serves as a roadmap for empirical research aimed at rigorously investigating the possible functions of music for romantic relationships

Harmonising regulatory information on wine protected designation of origin in Europe

Wine Protected Designation of Origin (PDO) products are strictly regulated and therefore highly susceptible to changes in climatic, environmental and socioeconomic conditions. Analysing the impacts of such changes has so far been challenging, because the legal specifications of wine PDOs in Europe have never been summarised in a harmonised dataset. Here, we present how we created the first inventory of regulatory information for the 1177 wine PDO in Europe, based on the geographical indication register of the European Union

A geospatial inventory of regulatory information for wine protected designations of origin in Europe

The Wine Protected Designation of Origin (PDO) label is a European quality scheme that protects high quality wines by linking them to legally defined geographic areas and a set of specific production practices. Because of the tight relation between PDO wines and the specifications defined in the official regulatory documents, these products are highly susceptible to changes in climatic, environmental, or socioeconomic conditions. However, the content of these regulatory documents has never been systematically analysed and summarized in a single dataset. Here, we present the first geospatial inventory that organizes regulatory information about the 1177 wine PDO in Europe based on the documents from the official EU geographical indication register. It includes essential legal information that defines the wine PDO such as the geographic boundaries, authorized cultivars and maximum yields. This inventory opens new possibilities for researchers to accurately assess, compare and map the regulatory information in each wine region at an unprecedented level of detail, supporting decision makers in developing adaptation strategies for the preservation of PDO wine regions

An ecosystem service approach to the study of vineyard landscapes in the context of climate change: a review

Vineyard landscapes significantly contribute to the economy, identity, culture, and biodiversity of many regions worldwide. Climate change, however, is increasingly threatening the resilience of vineyard landscapes and of their ecological conditions, undermining the provision of multiple ecosystem services. Previous research has often focused on climate change impacts, ecosystem conditions and ecosystem services without systematically reviewing how they have been studied in the literature on viticulture. Here, we systematically review the literature on vineyard landscapes to identify how ecosystem conditions and services have been investigated, and whether an integrative approach to investigate the effects of climate change was adopted. Our results indicate that there are still very few studies that explicitly address multiple ecosystem conditions and services together. Only 28 and 18% of the reviewed studies considered more than two ecosystem conditions or services, respectively. Moreover, while more than 97% of the relationships between ecosystem conditions and services studied were addressing provisioning and regulating services, only 3% examined cultural services. Finally, this review found that there is a lack of integrative studies that address simultaneously the relationships between ecosystem condition, ecosystem services and climate change (only 15 out of 112 studies). To overcome these gaps and to better understand the functioning of vineyard socio-ecological systems under climate change, multidisciplinary, integrative, and comprehensive approaches should be adopted by future studies. A holistic understanding of vineyard landscapes will indeed be crucial to support researchers and decision makers in developing sustainable adaptation strategies that enhance the ecological condition of vineyards and ensure the provision of multiple ecosystem services under future climate scenarios

A multi-pressure analysis of ecosystem services for conservation planning in the Alps

Increasing anthropogenic pressures such as pollution, climate change or invasive species can have multiple impacts on ecosystems and the services (ES) they provide. To address the potential effects on ES provision, we propose a geospatial framework to identify and analyze the cumulative effects on terrestrial and freshwater ES. The framework includs an impact chain analysis based on ten pressures grouped into six categories (pollution, climate change, land-use change, overexploitation, land fragmentation, invasive species) and their single or multiple effects on five key ES of the Alpine environment (recreation, forest protection, CO2 sequestration, habitat maintenance, grassland biomass). Results show that the areas most affected by cumulative effects were located in major urban centers, in the Po Valley, Germany, Slovenia, and in coastal areas of the Adriatic Sea. The spatial coincidence analysis of pressure P-ES on IUCN protected sites showed that protection categories IV and V mostly had high P/high ES scores. Our approach will help in management and planning for mountain conservation aimed at reducing multi-pressure occurrences in transboundary environments. The framework can be used to identify areas with the highest ES provision, characterize areas with high stress from anthropogenic pressures, and examine the effects of pressures on protected areas

Love songs and serenades: a theoretical review of music and romantic relationships

In this theoretical review, we examine how the roles of music in mate choice and social bonding are expressed in romantic relationships. Darwin’s Descent of Man originally proposed the idea that musicality might have evolved as a sexually selected trait. This proposition, coupled with the portrayal of popular musicians as sex symbols and the prevalence of love-themed lyrics in music, suggests a possible link between music and attraction. However, recent scientific exploration of the evolutionary functions of music has predominantly focused on theories of social bonding and group signaling, with limited research addressing the sexual selection hypothesis. We identify two distinct types of music-making for these different functions: music for attraction, which would be virtuosic in nature to display physical and cognitive fitness to potential mates; and music for connection, which would facilitate synchrony between partners and likely engage the same reward mechanisms seen in the general synchrony-bonding effect, enhancing perceived interpersonal intimacy as a facet of love. Linking these two musical functions to social psychological theories of relationship development and the components of love, we present a model that outlines the potential roles of music in romantic relationships, from initial attraction to ongoing relationship maintenance. In addition to synthesizing the existing literature, our model serves as a roadmap for empirical research aimed at rigorously investigating the possible functions of music for romantic relationships

Objective measurement of physical activity in a random sample of Saint-Petersburg inhabitants

Background: World Health Organization (WHO) experts listed physical inactivity in leading risk factors for global mortality. Current research shows that only objective measurement of physical activity may provide accurate information on this parameter. The aim of our study was to assess the 7-day physical activity monitoring using triaxial accelerometers in a random sample of Saint-Petersburg inhabitants. Material and methods: As a part of all-Russian epidemiology survey ESSE-RF there was involved random sampling of 1600 Saint-Petersburg inhabitants (25–65 years) stratified by age and sex. After that a random sub-population of 100 subjects was selected. All subjects filled in questionnaire regarding physical activity, occupation, education and nutrition. Anthropometry (weight, height with body-mass index calculation, waist circumference) was performed. Actigraph GT3X+ (Actigraph LLC, USA) accelerometer and physical activity diary were used in order to evaluate physical activity monitoring for 7 days. Adequate levels of physical activity (PA) were defined as more than 10 000 steps/day and at least 150 minutes/week of moderate and vigorous physical activity (MVPA) in bouts of 10 minutes or more. Results: 1/2 of subjects were physically active according to steps, and 1/3 according to MVPA time criteria. No gender, occupation or body composition differences were revealed in physically active and inactive subjects. Almost 50% of physically active subjects had balanced workweek-weekend PA profile, and the same criterion is true only for 13% of subjects in inactive group. In both groups the same peaks of MVPA were revealed — at 8.00–9.00 and 18.00–19.00, which are typical transportation time, but in active group these peaks were significantly higher. According to PA diaries, in most of cases physical inactivity was related to the usage of private or public transport. Conclusion: Triaxial PA-monitoring shows, that 40–60% of subjects were physically inactive, and 150-min MVPA goal can easily be achieved by only increasing walking time during transportation peaks. The physical inactivity was not determined by the type of occupation, sex or age, instead it was mainly influenced by the usage of cars in the morning and evening transportation time, rather than walking

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile

<p>Background: Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both pathologies. Gene therapy may provide a successful approach to improve the clinical outcome of these conditions, but would benefit from the development of more efficient vectors for vascular gene delivery. The aim of this study was to assess whether a novel genetically engineered Adenovirus could be utilised to produce enhanced levels of vascular gene expression.</p> <p>Methods: Vascular transduction capacity was assessed in primary human saphenous vein smooth muscle and endothelial cells using vectors expressing the LacZ reporter gene. The therapeutic capacity of the vectors was compared by measuring smooth muscle cell metabolic activity and migration following infection with vectors that over-express the candidate therapeutic gene tissue inhibitor of matrix metalloproteinase-3 (TIMP-3).</p> <p>Results: Compared to Adenovirus serotype 5 (Ad5), the novel vector Ad5T*F35++ demonstrated improved binding and transduction of human vascular cells. Ad5T*F35++ mediated expression of TIMP-3 reduced smooth muscle cell metabolic activity and migration in vitro. We also demonstrated that in human serum samples pre-existing neutralising antibodies to Ad5T*F35++ were less prevalent than Ad5 neutralising antibodies.</p> <p>Conclusions: We have developed a novel vector with improved vascular transduction and improved resistance to human serum neutralisation. This may provide a novel vector platform for human vascular gene transfer.</p&gt

Intralymphatic CCL21 promotes tissue egress of dendritic cells through afferent lymphatic vessels

To induce adaptive immunity, dendritic cells (DCs) migrate through afferent lymphatic vessels (LVs) to draining lymph nodes (dLNs). This process occurs in several consecutive steps. Upon entry into lymphatic capillaries, DCs first actively crawl into downstream collecting vessels. From there, they are next passively and rapidly transported to the dLN by lymph flow. Here, we describe a role for the chemokine CCL21 in intralymphatic DC crawling. Performing time-lapse imaging in murine skin, we found that blockade of CCL21-but not the absence of lymph flow-completely abolished DC migration from capillaries toward collecting vessels and reduced the ability of intralymphatic DCs to emigrate from skin. Moreover, we found that in vitro low laminar flow established a CCL21 gradient along lymphatic endothelial monolayers, thereby inducing downstream-directed DC migration. These findings reveal a role for intralymphatic CCL21 in promoting DC trafficking to dLNs, through the formation of a flow-induced gradient