Habiter les pentes de la colonie de Lugdunum : relecture des vestiges du Clos de la Solitude (Lyon 5e, 2013)

International audienc

Habiter les pentes de la colonie de Lugdunum : relecture des vestiges du Clos de la Solitude (Lyon 5e, 2013)

International audienc

« Le site du Clos de la Solitude – Lyon 5e ». Archeothema, 34, 2014, p. 78-79.

International audienc

« Le site du Clos de la Solitude – Lyon 5e ». Archeothema, 34, 2014, p. 78-79.

International audienc

Controlled Access to C 1 ‐Symmetrical Cyclotriveratrylenes (CTVs) by Using a Sequential Barluenga Boronic Coupling (BBC) Approach

International audienc

On-line capillary electrophoresis-based enzymatic methodology for the study of polymer-drug conjugates

International audienceThis work aims at studying the potentialities of an on-line capillary electrophoresis (CE)-based digestion methodology for evaluating polymer–drug conjugates degradability in the presence of free trypsin (in-solution digestion). A sandwich plugs injection scheme with transverse diffusion of laminar profile (TDLFP) mode was used to achieve on-line digestions. Electrophoretic separation conditions were established using poly-l-Lysine (PLL) as reference substrate. Comparison with off-line digestion was carried out to demonstrate the feasibility of the proposed methodology. The applicability of the on-line CE-based digestion methodology was evaluated for two PLL-drug conjugates and for the four first generations of dendrigraft of lysine (DGL). Different electrophoretic profiles presenting the formation of di, tri, and tetralysine were observed for PLL-drug and DGL. These findings are in good agreement with the nature of the linker used to link the drug to PLL structure and the predicted degradability of DGL. The present on-line methodology applicability was also successfully proven for protein conjugates hydrolysis. In summary, the described methodology provides a powerful tool for the rapid study of biodegradable polymers

Beta-nerve growth factor participates in an auto/paracine pathway of regulation of the meiotic differentiation of rat spermatocytes

International audienc

Synthesis and Physicochemical Properties of Cryptophazane—A Soluble and Functionalizable C 1 ‐Symmetrical Cryptophane

International audienc