Evidence of Planetesimal infall on to the very young Herbig Be star LkHα_\alpha234

We report here the first evidence for planetesimal infall onto the very young Herbig Be star LkH$_\alpha$234. These results are based on observations acquired over 31 days using spectroscopy of the sodium D lines, the He I 5876\AA, and hydrogen H$_\alpha$ lines. We find Redshifted Absorption Components (RAC) with velocities up to 200 km/s and very mild Blueshifted Absorption Components (BEC) up to 100 km/s in the Na I lines. No correlation is observed between the appearance of the Na I RAC & BEC and the H$_\alpha$ and He I line variability, which suggests that these (Na I RAC & BEC) are formed in a process unrelated to the circumstellar gas accretion. We interpret the Na I RAC as evidence for an infalling evaporating body, greater than 100 km in diameter, which is able to survive at distances between 2.0 to 0.1 AU from the star. The dramatic appearance of the sodium RAC and mild BEC is readily explained by the dynamics of this infalling body making LkH$_\alpha$234 the youngest (age $\sim$ 0.1 Myr) system with evidence for the presence of planetesimals.Comment: Accepted for publications in ApJLetter

Review of methods used by chiropractors to determine the site for applying manipulation

Background: With the development of increasing evidence for the use of manipulation in the management of musculoskeletal conditions, there is growing interest in identifying the appropriate indications for care. Recently, attempts have been made to develop clinical prediction rules, however the validity of these clinical prediction rules remains unclear and their impact on care delivery has yet to be established. The current study was designed to evaluate the literature on the validity and reliability of the more common methods used by doctors of chiropractic to inform the choice of the site at which to apply spinal manipulation. Methods: Structured searches were conducted in Medline, PubMed, CINAHL and ICL, supported by hand searches of archives, to identify studies of the diagnostic reliability and validity of common methods used to identify the site of treatment application. To be included, studies were to present original data from studies of human subjects and be designed to address the region or location of care delivery. Only English language manuscripts from peer-reviewed journals were included. The quality of evidence was ranked using QUADAS for validity and QAREL for reliability, as appropriate. Data were extracted and synthesized, and were evaluated in terms of strength of evidence and the degree to which the evidence was favourable for clinical use of the method under investigation. Results: A total of 2594 titles were screened from which 201 articles met all inclusion criteria. The spectrum of manuscript quality was quite broad, as was the degree to which the evidence favoured clinical application of the diagnostic methods reviewed. The most convincing favourable evidence was for methods which confirmed or provoked pain at a specific spinal segmental level or region. There was also high quality evidence supporting the use, with limitations, of static and motion palpation, and measures of leg length inequality. Evidence of mixed quality supported the use, with limitations, of postural evaluation. The evidence was unclear on the applicability of measures of stiffness and the use of spinal x-rays. The evidence was of mixed quality, but unfavourable for the use of manual muscle testing, skin conductance, surface electromyography and skin temperature measurement. Conclusions: A considerable range of methods is in use for determining where in the spine to administer spinal manipulation. The currently published evidence falls across a spectrum ranging from strongly favourable to strongly unfavourable in regard to using these methods. In general, the stronger and more favourable evidence is for those procedures which take a direct measure of the presumptive site of care– methods involving pain provocation upon palpation or localized tissue examination. Procedures which involve some indirect assessment for identifying the manipulable lesion of the spine–such as skin conductance or thermography–tend not to be supported by the available evidence.https://doi.org/10.1186/2045-709X-21-3

A SOY-PROTEIN-BASED DIET DOES NOT ALTER SERUM MARKERS OF BONE FORMATION AND RESORPTION IN OVARIECTOMIZED, LOW-FIT RATS

Matthew W. Richard, Laura C. Ortinau, Terese Z. Zidon, Pamela S. Hinton and Victoria Viera-Potter. University of Missouri, Columbia, MO; e-mail: [email protected] Osteoporosis and the associated increased risk of fracture are serious health concerns for postmenopausal women. In addition to a significant decline in estrogen post-menopause, decreased physical activity may further predispose women to osteoporosis. The soy isoflavones genistein and daidzein are phytoestrogens, and, therefore, might reduce the negative effects of estrogen loss on bone. Low-capacity runner (LCR) rats are selectively bred for intrinsically low aerobic fitness and might serve as an effective model of menopause, following ovariectomy. Purpose: Therefore, the purpose of this study was to examine the effects of a soy-protein-based diet or a corn-based-diet on serum bone markers of formation and resorption in ovariectomized, low-capacity runner (LCR) rats. Methods: LCR rats were either ovariectomized or sham operated and fed a soy-protein-based diet (600 ppm genistein+daidzein; SOY) or a corn-gluten-meal-based protein diet (\u3c15 ppm genistein+daidzein; CORN) for 23 weeks. Bone formation (osteocalcin, OC; propeptide type I procollagen, P1NP) and resorption (tartrate-resistant acid phosphatase, TRAP5b; C-terminal telopeptide of type I collagen, CTx) serum markers in LCR rats were measured following ovariectomy (OVX) or sham (SHAM) surgery at 28 weeks of age. Results: Final body weight was significantly increased by OVX vs. SHAM (p=0.002), but not by diet. P1NP, OC, TRAP5b, and CTx were measured in plasma using ELISAs. A two-factor (OVX, diet) ANOVA was used to test for significant main and interactive effects. There was a trend for OC and CTx to be higher and TRAP5b lower in OVX vs. SHAM (main effects: p=0.098, p=0.083, and p=0.099, respectively). In OVX, P1NP/CTx was significantly less than SHAM (p=0.003). Conclusion: There were no effects of diet on serum bone markers. In conclusion, serum markers of bone formation and resorption are affected by OVX, but not by a soy-protein-based diet, in LCR rats

ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016.

Meeting abstrac