2-Point Moments in Cosmological Large Scale Structure: I. Theory and Comparison with Simulations

We present new perturbation theory (PT) predictions in the Spherical Collapse (SC) model for the 2-point moments of the large-scale distribution of dark matter density in the universe. We assume that these fluctuations grow under gravity from small Gaussian initial conditions. These predictions are compared with numerical simulations and with previous PT results to assess their domain of validity. We find that the SC model provides in practice a more accurate description of 2-point moments than previous tree-level PT calculations. The agreement with simulations is excellent for a wide range of scales (5-50 Mpc/h) and fluctuations amplitudes (0.02-2 variance). When normalized to unit variance these results are independent of the cosmological parameters and of the initial amplitude of fluctuations. The 2-point moments provide a convenient tool to study the statistical properties of gravitational clustering for fairly non-linear scales and complicated survey geometries, such as those probing the clustering of the Ly-alpha forest. In this context, the perturbative SC predictions presented here, provide a simple and novel way to test the gravitational instability paradigm.Comment: 10 LaTeX pages, 9 figs, submitted to MNRA

Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas.

The high-affinity folate-binding protein (FBP) is primarily involved in the uptake of the 5-methyltetrahydrofolate, and its expression may be physiologically regulated by the intracellular folate content. The overexpression of FBP on the cell surface of ovarian carcinoma cells may be responsible for an increased folate uptake. We tested the hypothesis of the existence of a defect in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) in ovarian tumours that could cause reduced intracellular regeneration of the 5-methyltetrahydrofolate and induce increased FBP expression. No sequence mutations were found in the MTHFR gene, but allelic deletions of this gene were frequently detected in ovarian tumours (59%). Chromosomal losses appeared to be confined to the 1p36.3 region to which the MTHFR gene maps. Although it cannot be stated that MTHFR is the target gene of the chromosomal loss involving the 1p36.3 region, a correlation between loss of heterozygosity at this locus and decrease in MTHFR activity was shown, suggesting a role of these allelic deletions in generating a biochemical defect in folate metabolism. Further studies are needed to assess further the relationship between MTHFR and FBP overexpression, but the demonstration of the alteration of a key metabolic enzyme of the folate cycle in a subset of human ovarian tumours is in accordance with the hypothesis of an altered folate metabolism in these neoplasias and might be exploited for therapeutic purposes

From Espresso to Codex

CODEX and ESPRESSO are concepts for ultra-stable, high-resolution spectrographs at the E-ELT and VLT, respectively. Both instruments are well motivated by distinct sets of science drivers. However, ESPRESSO will also be a stepping stone towards CODEX both in a scientific as well as in a technical sense. Here we discuss this role of ESPRESSO with respect to one of the most exciting CODEX science cases, i.e. the dynamical determination of the cosmic expansion history.Comment: To appear in the Proceedings of the Workshop "Science with the VLT in the ELT era", 8-12 October 2007, Garching, A. Moorwood, e

Constraining Primordial Non-Gaussianity with High-Redshift Probes

We present an analysis of the constraints on the amplitude of primordial non-Gaussianity of local type described by the dimensionless parameter $f_{\rm NL}$. These constraints are set by the auto-correlation functions (ACFs) of two large scale structure probes, the radio sources from NRAO VLA Sky Survey (NVSS) and the quasar catalogue of Sloan Digital Sky Survey Release Six (SDSS DR6 QSOs), as well as by their cross-correlation functions (CCFs) with the cosmic microwave background (CMB) temperature map (Integrated Sachs-Wolfe effect). Several systematic effects that may affect the observational estimates of the ACFs and of the CCFs are investigated and conservatively accounted for. Our approach exploits the large-scale scale-dependence of the non-Gaussian halo bias. The derived constraints on {$f_{\rm NL}$} coming from the NVSS CCF and from the QSO ACF and CCF are weaker than those previously obtained from the NVSS ACF, but still consistent with them. Finally, we obtain the constraints on $f_{\rm NL}=53\pm25$ ($1\,\sigma$) and $f_{\rm NL}=58\pm24$ ($1\,\sigma$) from NVSS data and SDSS DR6 QSO data, respectively.Comment: 16 pages, 8 figures, 1 table, Accepted for publication on JCA

Neutrino masses and cosmic radiation density: Combined analysis

We determine the range of neutrino masses and cosmic radiation content allowed by the most recent CMB and large-scale structure data. In contrast to other recent works, we vary these parameters simultaneously and provide likelihood contours in the two-dimensional parameter space of N_eff}, the usual effective number of neutrino species measuring the radiation density, and \sum m_nu. The allowed range of \sum m_nu and N_eff has shrunk significantly compared to previous studies. The previous degeneracy between these parameters has disappeared, largely thanks to the baryon acoustic oscillation data. The likelihood contours differ significantly if \sum m_nu resides in a single species instead of the standard case of being equally distributed among all flavors. For \sum m_nu=0 we find 2.7 < N_eff < 4.6 at 95% CL while \sum m_nu < 0.62 eV at 95% CL for the standard radiation content.Comment: 8 pages, 2 figure

ESPRESSO: The next European exoplanet hunter

The acronym ESPRESSO stems for Echelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observations; this instrument will be the next VLT high resolution spectrograph. The spectrograph will be installed at the Combined-Coud\'e Laboratory of the VLT and linked to the four 8.2 m Unit Telescopes (UT) through four optical Coud\'e trains. ESPRESSO will combine efficiency and extreme spectroscopic precision. ESPRESSO is foreseen to achieve a gain of two magnitudes with respect to its predecessor HARPS, and to improve the instrumental radial-velocity precision to reach the 10 cm/s level. It can be operated either with a single UT or with up to four UTs, enabling an additional gain in the latter mode. The incoherent combination of four telescopes and the extreme precision requirements called for many innovative design solutions while ensuring the technical heritage of the successful HARPS experience. ESPRESSO will allow to explore new frontiers in most domains of astrophysics that require precision and sensitivity. The main scientific drivers are the search and characterization of rocky exoplanets in the habitable zone of quiet, nearby G to M-dwarfs and the analysis of the variability of fundamental physical constants. The project passed the final design review in May 2013 and entered the manufacturing phase. ESPRESSO will be installed at the Paranal Observatory in 2016 and its operation is planned to start by the end of the same year.Comment: 12 pages, figures included, accepted for publication in Astron. Nach

The importance of sex as a risk factor for hospital readmissions due to pulmonary diseases

BACKGROUND: Pulmonary diseases are a common and costly cause of 30-day readmissions. Few studies have focused on the difference in risk for rehospitalization between men and women in older patients. In this study we analyzed the association between sex and the risk of readmission in a cohort of patients admitted to the hospital for chronic obstructive pulmonary disease (COPD) exacerbation and other major pulmonary diseases. METHODS: This was a retrospective cohort study based on administrative data collected in the Veneto Region in 2016. We included 14,869 hospital admissions among residents aged 6565\u2009years for diagnosis related groups (DRGs) of the most common disorders of the respiratory system: bronchitis and asthma, pneumonia, pulmonary edema, respiratory failure, and COPD. Multilevel logistic regressions were performed to test the association between 30-day hospital readmission and sex, adjusting for confounding factors. RESULTS: For bronchitis and asthma, male patients had significantly higher odds of 30-day readmission than female patients (adjusted odds ratio (aOR), 2.07; 95% confidence interval (CI), 1.11-3.87). The odds of readmission for men were also significantly higher for pneumonia (aOR, 1.40; 95% CI, 1.13-1.72), for pulmonary edema and respiratory failure (aOR, 1.28; 95% CI, 1.05-1.55), and for COPD (aOR, 1.34; 95% CI, 1.00-1.81). CONCLUSIONS: This study found that male sex is a major risk factors for readmission in patients aged more than 65\u2009years with a primary pulmonary diagnosis. More studies are needed to understand the underlying determinants of this phenomena and to provide targets for future interventions