El sector conservero y semiconservero de pescados y de mariscos: claves de futuro

Texto dispoñible en galego e españolS

Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer

Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in LC translates into the clinic. First, the mRNA expression of 518 non-small cell LC (NSCLC) cases from The Cancer Genome Atlas (TCGA) database was evaluated. Patients with PFDN1 overexpression had lower overall survival (OS; 45 vs. 86 months; p = 0.034). We then assessed the impact of PFDN expression on outcome in 58 NSCLC patients with available tumor tissue samples. PFDN1, 3, and 5 overexpression were found in 38% (n = 22), 53% (n = 31), and 41% (n = 24) of tumor samples. PFDN1, 3, and 5 overexpression were significantly associated with lower OS, lower disease-free survival (DFS), and lower distant metastasis-free survival (DMFS) for PFDN1 and 3 with a trend for PFDN5. In multivariate analysis, PFDN5 retained significance for OS (hazard ratio (HR) 2.56; p = 0.007) and PFDN1 for DFS (HR 2.53; p = 0.010) and marginally for DMFS (HR 2.32; p = 0.053). Our results indicate that protein response markers, such as PFDN1, 3, and 5, may complement mRNA signatures and be useful for determining the most appropriate therapy for NSCLC patients

Brain atrophy and clinical characterization of adults with mild cognitive impairment and different cerebrospinal fluid biomarker profiles according to the AT(N) research framework of Alzheimer’s disease

Introduction: This study aimed to evaluate, in adults with mild cognitive impairment (MCI), the brain atrophy that may distinguish between three AT(N) biomarker-based profiles, and to determine its clinical value. Methods: Structural MRI (sMRI) was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT(N) profiles, namely, A−T−(N)−: normal AD biomarkers; A+T−(N)−: AD pathologic change; and A+T+(N)+: prodromal AD. Sensitivity and specificity of these changes were also estimated. Results: An initial atrophy in medial temporal lobe (MTL) areas was found in the A+T−(N)− and A+T+(N)+ groups, spreading toward the parietal and frontal regions in A+T+(N)+ patients. These structural changes allowed distinguishing AT(N) profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status. Conclusion: sMRI is useful in the determination of the specific brain structural changes of AT(N) profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkersThis study was supported by grants from the Spanish Government, Ministerio de Ciencia e Innovación (PSI2017- 89389-C2-R and PID2020-114521RB-C21/C22); the Galician Government, Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807- USC); Refs: ED431-2017/27 and ED431C-2021/04; all with ERDF/FEDER fundsS

Measurement of forward Z → e+e− production s√s=8 TeV

A measurement of the cross-section for Z-boson production in the forward region of pp collisions at 8 TeV centre-of-mass energy is presented. The measurement is based on a sample of Z → e+e− decays reconstructed using the LHCb detector, corresponding to an integrated luminosity of 2.0 fb−1. The acceptance is defined by the requirements 2.0 20 GeV for the pseudorapidities and transverse momenta of the leptons. Their invariant mass is required to lie in the range 60-120 GeV. The cross-section is determined to beS

Measurement of indirect CP asymmetries in D0 → K−K+ and D0 → π−π+ decays using semileptonic B decays

Time-dependent CP asymmetries in the decay rates of the singly Cabibbo-suppressed decays D0 → K−K+ and D0 → π−π+ are measured in pp collision data corresponding to an integrated luminosity of 3.0 fb−1 collected by the LHCb experiment. The D0 mesons are produced in semileptonic b-hadron decays, where the charge of the accompanying muon is used to determine the initial state as D0 or D¯0. The asymmetries in effective lifetimes between D0 and D¯0 decays, which are sensitive to indirect CP violation, are determined to be AΓ(K−K+)=(−0.134±0.077−0.026−0.034)%,AΓ(π−π+)=(−0.092±0.145−0.025−0.033)%, where the first uncertainties are statistical and the second systematic. This result is in agreement with previous measurements and with the hypothesis of no indirect CP violation in D0 decays.S

Precise measurements of the properties of the B1(5721)0,+ and B *2(5747)0,+ states and observation of B+,0π−,+ mass structures

Invariant mass distributions of B+π− and B0π+ combinations are investigated in order to study excited B mesons. The analysis is based on a data sample corresponding to 3.0 fb−1 of pp collision data, recorded by the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Precise measurements of the masses and widths of the B1(5721)0,+ and B2(5747)0,+ states are reported. Clear enhancements, particularly prominent at high pion transverse momentum, are seen over background in the mass range 5850-6000 MeV in both B+π− and B0π+ combinations. The structures are consistent with the presence of four excited B mesons, labelled B J (5840)0,+ and B J (5960)0,+, whose masses and widths are obtained under different hypotheses for their quantum numbersS

Measurement of CP asymmetries and polarisation fractions in B0s→K∗0K¯∗0 decays

An angular analysis of the decay B0s→K∗0K¯∗0 is performed using pp collisions corresponding to an integrated luminosity of 1.0 fb−1 collected by the LHCb experiment at a centre-of-mass energy s√=7 TeV. A combined angular and mass analysis separates six helicity amplitudes and allows the measurement of the longitudinal polarisation fraction f L = 0.201 ± 0.057 (stat.) ± 0.040 (syst.) for the B0s→K∗(892)0K¯∗(892)0 decay. A large scalar contribution from the K ∗0(1430) and K ∗0(800) resonances is found, allowing the determination of additional CP asymmetries. Triple product and direct CP asymmetries are determined to be compatible with the Standard Model expectations. The branching fraction B(Bs→K∗(892)0K¯∗(892)0) is measured to be (10.8 ± 2.1 (stat.) ± 1.4 (syst.) ± 0.6 (f d /f s )) × 10−6.S

Observation of the B0→ρ0ρ0 decay from an amplitude analysis of B0→(π+π−)(π+π−)decays

Proton–proton collision data recorded in 2011 and 2012 by the LHCb experiment, corresponding to an integrated luminosity of 3.0fb−1, are analysed to search for the charmless B0→ρ0ρ0decay. More than 600 B0→(π+π−)(π+π−)signal decays are selected and used to perform an amplitude analysis, under the assumption of no CP violation in the decay, from which the B0→ρ0ρ0decay is observed for the first time with 7.1 standard deviations significance. The fraction of B0→ρ0ρ0decays yielding a longitudinally polarised final state is measured to be fL=0.745+0.048−0.058(stat) ±0.034(syst). The B0→ρ0ρ0branching fraction, using the B0→φK∗(892)0decay as reference, is also reported as B(B0→ρ0ρ0)=(0.94±0.17(stat)±0.09(syst)±0.06(BF))×10−6S

Study of the rare B0s and B0s decays into the π+π−μ+μ−final state

A search for the rare decays B0s→π+π−μ+μ−and B0→π+π−μ+μ−is performed in a data set corresponding to an integrated luminosity of 3.0fb−1collected by the LHCb detector in proton–proton collisions at centre-of-mass energies of 7 and 8TeV. Decay candidates with pion pairs that have invariant mass in the range 0.5–1.3GeV/c2and with muon pairs that do not originate from a resonance are considered. The first observation of the decay B0s→π+π−μ+μ−and the first evidence of the decay B0→π+π−μ+μ−are obtained and the branching fractions, restricted to the dipion-mass range considered, are measured to be B(B0s→π+π−μ+μ−) =(8.6 ±1.5(stat) ±0.7(syst) ±0.7 (norm)) ×10−8and B(B0→π+π−μ+μ−) =(2.11±0.51(stat)±0.15(syst)±0.16(norm))×10−8, where the third uncertainty is due to the branching fraction of the decay B0→J/ψ(→μ+μ−)K∗(892)0(→K+π−), used as a normalisation.S

Measurement of the CP-violating phase βin B0→J/ψπ+π−decays and limits on penguin effects

Time-dependent CPviolation is measured in the (—)B0→J/ψπ+π−channel for each π+π−resonant final state using data collected with an integrated luminosity of 3.0fb−1in ppcollisions using the LHCb detector. The final state with the largest rate, J/ψρ0(770), is used to measure the CP-violating angle 2βeffto be (41.7 ±9.6+2.8−6.3)◦.This result can be used to limit the size of penguin amplitude contributions to CPviolation measurements in, for example, (—)B0s→J/ψφdecays. Assuming approximate SU(3) flavour symmetry and neglecting higher order diagrams, the shift in the CP-violating phase φsis limited to be within the interval [−1.05◦, +1.18◦] at 95% confidence level. Changes to the limit due to SU(3) symmetry breaking effects are also discussed.S