792 research outputs found
Delay in maturation of the submandibular gland in Chagas disease correlates with lower DNA synthesis
Persistence of magnetic field driven by relativistic electrons in a plasma
The onset and evolution of magnetic fields in laboratory and astrophysical
plasmas is determined by several mechanisms, including instabilities, dynamo
effects and ultra-high energy particle flows through gas, plasma and
interstellar-media. These processes are relevant over a wide range of
conditions, from cosmic ray acceleration and gamma ray bursts to nuclear fusion
in stars. The disparate temporal and spatial scales where each operates can be
reconciled by scaling parameters that enable to recreate astrophysical
conditions in the laboratory. Here we unveil a new mechanism by which the flow
of ultra-energetic particles can strongly magnetize the boundary between the
plasma and the non-ionized gas to magnetic fields up to 10-100 Tesla (micro
Tesla in astrophysical conditions). The physics is observed from the first
time-resolved large scale magnetic field measurements obtained in a laser
wakefield accelerator. Particle-in-cell simulations capturing the global plasma
and field dynamics over the full plasma length confirm the experimental
measurements. These results open new paths for the exploration and modelling of
ultra high energy particle driven magnetic field generation in the laboratory
Expression and trans-specific polymorphism of self-incompatibility RNases in Coffea (Rubiaceae)
Self-incompatibility (SI) is widespread in the angiosperms, but identifying the biochemical components of SI mechanisms has proven to be difficult in most lineages. Coffea (coffee; Rubiaceae) is a genus of old-world tropical understory trees in which the vast majority of diploid species utilize a mechanism of gametophytic self-incompatibility (GSI). The S-RNase GSI system was one of the first SI mechanisms to be biochemically characterized, and likely represents the ancestral Eudicot condition as evidenced by its functional characterization in both asterid (Solanaceae, Plantaginaceae) and rosid (Rosaceae) lineages. The S-RNase GSI mechanism employs the activity of class III RNase T2 proteins to terminate the growth of "self" pollen tubes. Here, we investigate the mechanism of Coffea GSI and specifically examine the potential for homology to S-RNase GSI by sequencing class III RNase T2 genes in populations of 14 African and Madagascan Coffea species and the closely related self-compatible species Psilanthus ebracteolatus. Phylogenetic analyses of these sequences aligned to a diverse sample of plant RNase T2 genes show that the Coffea genome contains at least three class III RNase T2 genes. Patterns of tissue-specific gene expression identify one of these RNase T2 genes as the putative Coffea S-RNase gene. We show that populations of SI Coffea are remarkably polymorphic for putative S-RNase alleles, and exhibit a persistent pattern of trans-specific polymorphism characteristic of all S-RNase genes previously isolated from GSI Eudicot lineages. We thus conclude that Coffea GSI is most likely homologous to the classic Eudicot S-RNase system, which was retained since the divergence of the Rubiaceae lineage from an ancient SI Eudicot ancestor, nearly 90 million years ago.United States National Science Foundation [0849186]; Society of Systematic Biologists; American Society of Plant Taxonomists; Duke University Graduate Schoolinfo:eu-repo/semantics/publishedVersio
Stage at presentation of breast cancer in Luanda, Angola - a retrospective study
Background: It is expected that, by 2020, 15 million new cases of cancer will occur every year in the world, one
million of them in Africa. Knowledge of cancer trends in African countries is far from adequate, and improvements in cancer prevention efforts are urgently needed. The aim of this study was to characterize breast cancer clinically and pathologically at presentation in Luanda, Angola; we additionally provide quality information that will be useful for breast cancer care planning in the country.
Methods:
Data on breast cancer cases were retrieved from the Angolan Institute of Cancer Control, from 2006 to 2014. For women diagnosed in 2009 (5-years of follow-up), demographic, clinical and pathological information, at presentation, was collected, namely age at diagnosis, parity, methods used for pathological diagnoses, tumor
pathological characteristics, stage of disease and treatment. Descriptive statistics were performed.
Results:
The median age of women diagnosed with breast cancer in 2009 was 47 years old (range 25–89). The most frequent clinical presentation was breast swelling with axillary lymph nodes metastasis (44.9 %), followed by a mass
larger than 5 cm (14.2 %) and lump (12.9 %). Invasive ductal carcinoma was the main histologic type (81.8 %). Only 10.1 % of cancer cases had a well differentiated histological grade. Cancers were diagnosed mostly at advanced stages
(66.7 % in stage III and 11.1 % in stage IV).
Discussion:
In this study, breast cancer was diagnosed at a very advanced stage. Although it reports data from a single cancer center in Luanda, Angola it reinforces the need for early diagnosis and increasing awareness. According to the
main challenges related to breast cancer diagnosis and treatment herein presented, we propose a realistic framework that would allow for the implementation of a breast cancer care program, built under a strong network based on cooperation, teaching, audit, good practices and the organization of health services.
Conclusion:
Angola needs urgently a program for early diagnosis of breast cancer.We thank Susana Santos for correction of the article in English language, and a Cancer Registry Staff from IACC, particularly Pedro Luis Hernandez Gonzalez, Paulo Ernesto Alves, Xacu Parica and Alberto Sivi Lutumba for their support in data acquisition. We also thank SEMED -Portugal in support for publication
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