THE CONTINUITY OF THE ANTIQUE COMPOSITIONAL PRINCIPLES IN THE ARCHITECTURE OF THE EUFRASIAN BASILICA

El artículo aborda la supervivencia de los modos de construcción más allá de la caída del Imperio Romano, en particular se discuten las medidas de la basílica eufrasiana desde el punto de vista de la metodología, el ritmo modular, proporción y simbolismo numérico

THE CONTINUITY OF THE ANTIQUE COMPOSITIONAL PRINCIPLES IN THE ARCHITECTURE OF THE EUFRASIAN BASILICA

This article studies the remains of the ways of building after the Fa11 of the Roman Empire and discusses, in particular, the size of the eufrasian basilique from the methodological point of view, the modular rythm, the proportion and numerical symbolism.El artículo aborda la supervivencia de los modos de construcción más allá de la caída del Imperio Romano, en particular se discuten las medidas de la basílica eufrasiana desde el punto de vista de la metodología, el ritmo modular, proporción y simbolismo numérico

The continuity of the antique compositional principles in the architecture of Eufrasian basilica

Vidmar, Aleksander El artículo aborda la supervivencia de los modos de construcción más allá de la caída del Imperio Romano, en particular se discuten las medidas de la basílica eufrasiana desde el punto de vista de la metodología, el ritmo modular, proporción y simbolismo numéric

Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells

Cysteine cathepsins are proteases that, in addition to their important physiological functions, have been associated with multiple pathologies, including cancer. Cystatin C (CstC) is a major endogenous inhibitor that regulates the extracellular activity of cysteine cathepsins. We investigated the role of cystatin C in mammary cancer using CstC knockout mice and a mouse model of breast cancer induced by expression of the polyoma middle T oncoprotein (PyMT) in the mammary epithelium. We showed that the ablation of CstC reduced the rate of mammary tumor growth. Notably, a decrease in the proliferation of CstC knockout PyMT tumor cells was demonstrated ex vivo and in vitro, indicating a role for this protease inhibitor in signaling pathways that control cell proliferation. An increase in phosphorylated p-38 was observed in CstC knockout tumors, suggesting a novel function for cystatin C in cancer development, independent of the TGF-β pathway. Moreover, proteomic analysis of the CstC wild-type and knockout PyMT primary cell secretomes revealed a decrease in the levels of 14-3-3 proteins in the secretome of knock-out cells, suggesting a novel link between cysteine cathepsins, cystatin C and 14-3-3 proteins in tumorigenesis, calling for further investigations

Antibacterial evaluation of different prosthetic liner textiles coated by CuO nanoparticles

Prosthetic liners are mainly used as an interface between residual limbs and prosthetic sockets to minimize physical and biological damage to soft tissue. However, the closed and moist conditions within liners and the amputee\u27s skin provide a suitable environment for bacterial growth to cause infections. This study aimed to coat a comprehensive variant material with copper oxide nanoparticles (CuO NPs) and compare their surface analysis and antibacterial properties. These materials were covered with CuO NPs solution at a concentration of 70 μg mL−1 to achieve this purpose. After drying, their surface characteristics were analyzed by measuring zeta potential, contact angle, surface roughness, and fiber arrangement. Cu-released concentration from the coatings into the acetate buffer solution by inductively coupled plasma mass spectrometry indicated that lycra and nylon quickly released Cu ions to concentrations up to ∼0.2 μg mL−1 after 24 h, causing low metabolic activity of human bone–marrow mesenchymal stem cells (bMSC) in the indirect assay. Antibacterial activity of the coated specimens was evaluated by infecting their surfaces with the Gram-positive bacteria Staphylococcus epidermidis, reporting a significant ∼40 % reduction of metabolic activity for x-dry after 24 hin addition, the number of viable bacterial colonies adhered to the surface of this material was reduced by ∼23 times in comparison with non-treated x-dry that were visually confirmed by scanning electron microscope. In conclusion, CuO NPs x-dry shows optimistic results to pursue further experiments due to its slow speed of Cu release and prolonged antibacterial activity, as well as its compatibility with human cells