Connexin-Based Channels and RhoA/ROCK Pathway in Angiotensin II-Induced Kidney Damage

The incidence of chronic kidney diseases is increasing worldwide, and there is no efficient therapy to reduce this phenomenon. The main therapies currently available focus on the control of blood pressure and the optimization of the blockade of the renin-angiotensin system (RAS). In addition, it is known that in several models of kidney damage, the amounts of connexins are altered. On the other hand, fasudil, a selective ROCK blocker, has shown renoprotective effects. The beneficial effects of blocking the RhoA/ROCK pathway in renal function may be related to its action of reducing macrophage infiltration, inflammation, and oxidative stress (OS), its expression of extracellular matrix genes and proteinuria, or to its effects on connexin abundance. Even though a correlation has been found between renal damage, caused by an increase in the RAS activity, connexins, and the RhoA/ROCK signaling pathway, it has not yet been possible to clearly determine its functional significance. Moreover, it has not been possible to identify the preponderance of this signaling pathway in the development of chronic kidney diseases. Here, we describe the advances in this subject

Estrategias de marketing y exportación de las mypes productoras de chirimoya de San Mateo de Otao hacia Alemania, 2017

En la investigación titulada estrategias de marketing y la exportación de las mypes productoras de la chirimoya de San Mateo de Otao hacia Alemania, 2017, tuvo como objetivo principal determinar la relación que existe entre las estrategias de marketing y la exportación de las mypes productoras de chirimoya de San Mateo de Otao hacia Alemania, 2017. El tipo de investigación fue aplicada, donde el nivel de investigación es correlacional de un diseño de investigación no experimental. Se utilizó como población a 20 mypes productoras de chirimoya del distrito de San Mateo de Otao, teniendo como muestra 20. La validez del instrumento se obtuvo mediante juicio de expertos y la confiabilidad con el coeficiente Alfa de Cronbach. La recolección de datos se obtuvo a través de 2 cuestionarios con 38 ítems con escala de 5 categorías. El análisis de los datos se hizo utilizando el programa estadístico SPSS versión 25 llegando a evidenciar que existe relación significativa entre las estrategias de marketing y la exportación de las mypes productoras de chirimoya de San Mateo de Otao hacia Alemania, 2017

Desafíos e ideas en la endocarditis por Aggregatibacter aphrophilus: una revisión de la literatura

Infective endocarditis is a serious disease associated with high mortality despite recent advances in diagnosis and treatment. Aggregatibacter aphrophilus is a fastidious Gram-negative member of the HACEK organisms (Haemophilus spp., Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae). A. aphrophilus is associated with dental infections but has also been implicated in cases of infective endocarditis. We highlight the importance of a high index of suspicion in symptomatic patients with an initial negative blood culture, particularly in high-risk groups such as patients with congenital valve disease and prosthetic valve. The knowledge of this rare entity may lead to early diagnosis and appropriate management. We review the main characteristics of Aggregatibacter aphrophilus endocarditis reported in the medical literature.La endocarditis infecciosa es una enfermedad grave que está asociada con una alta mortalidad a pesar de los avances recientes en el diagnóstico y tratamiento. Aggregatibacter aphrophilus es un miembro Gram-negativo de los organismos HACEK (Haemophilus spp., Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens y Kingella kingae). A. aphrophilus está relacionado con infecciones dentales, pero también ha estado implicado en casos de endocarditis infecciosa. Se destaca la importancia de tener un alto índice de sospecha en pacientes sintomáticos con un cultivo sanguíneo inicial negativo, especialmente en grupos de alto riesgo como pacientes con enfermedad valvular congénita y válvula protésica. El conocimiento de esta entidad poco común puede llevar a un diagnóstico temprano y un manejo adecuado. Revisamos las principales características de la endocarditis por Aggregatibacter aphrophilus reportadas en la literatura médica

Challenges and Insights in Aggregatibacter aphrophilus endocarditis: a review of literature

Infective endocarditis is a serious disease associated with high mortality despite recent advances in diagnosis and treatment. Aggregatibacter aphrophilus is a fastidious Gram-negative member of the HACEK organisms (Haemophilus spp., Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae). A. aphrophilus is associated with dental infections but has also been implicated in cases of infective endocarditis. We highlight the importance of a high index of suspicion in symptomatic patients with an initial negative blood culture, particularly in high-risk groups such as patients with congenital valve disease and prosthetic valve. The knowledge of this rare entity may lead to early diagnosis and appropriate management. We review the main characteristics of Aggregatibacter aphrophilus endocarditis reported in the medical literature.Infective endocarditis is a serious disease associated with high mortality despite recent advances in diagnosis and treatment. Aggregatibacter aphrophilus is a fastidious Gram-negative member of the HACEK organisms (Haemophilus spp., Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae). A. aphrophilus is associated with dental infections but has also been implicated in cases of infective endocarditis. We highlight the importance of a high index of suspicion in symptomatic patients with an initial negative blood culture, particularly in high-risk groups such as patients with congenital valve disease and prosthetic valve. The knowledge of this rare entity may lead to early diagnosis and appropriate management. We review the main characteristics of Aggregatibacter aphrophilus endocarditis reported in the medical literature

An unusual case of Candida parapsilosis endocarditis of the native tricuspid valve secondary to a tunneled dialysis catheter

Candida endocarditis is a severe disease associated with high mortality rates. Candida parapsilosis is frequently identified as the causative pathogen in intravenous drug users and is commonly associated with nosocomial infections, primarily due to its ability to form biofilms on catheters or other foreign bodies. Here, we present a rare case of Candida parapsilosis endocarditis affecting the native tricuspid valve in a 35-year-old male patient with end-stage chronic kidney disease (Stage V), who had a suspected fungal infection related to the left cervical catheter. The patient received treatment with caspofungin and underwent excision of a verrucous tumor on the tricuspid valve. Despite encountering postoperative complications, the patient was discharged on fluconazole treatment and scheduled for follow-up. Candida endocarditis poses a clinical challenge that necessitates a multidisciplinary approach and tailored management due to its infrequent occurrence and higher mortality rate compared to bacterial endocarditis.Candida endocarditis is a severe disease associated with high mortality rates. Candida parapsilosis is frequently identified as the causative pathogen in intravenous drug users and is commonly associated with nosocomial infections, primarily due to its ability to form biofilms on catheters or other foreign bodies. Here, we present a rare case of Candida parapsilosis endocarditis affecting the native tricuspid valve in a 35-year-old male patient with end-stage chronic kidney disease (Stage V), who had a suspected fungal infection related to the left cervical catheter. The patient received treatment with caspofungin and underwent excision of a verrucous tumor on the tricuspid valve. Despite encountering postoperative complications, the patient was discharged on fluconazole treatment and scheduled for follow-up. Candida endocarditis poses a clinical challenge that necessitates a multidisciplinary approach and tailored management due to its infrequent occurrence and higher mortality rate compared to bacterial endocarditis

Dysfunction endothelial evaluation in type 2 diabetes patients

El objetivo de este trabajo fue estudiar moléculas involucradas en la activación endotelial, tales como la molécula de adhesión sE-Selectina (sE-S) y el péptido vasoconstrictor Endotelina-1 (ET-1) en individuos diabéticos tipo 2 y su asociación con otros factores de riesgo cardiovascular. Se estudiaron 62 pacientes diabéticos que se compararon con un grupo control. Las concentraciones de sE-S y ET-1 fueron significativamente mayores en los diabéticos que en los controles (sE-S: 90,6±26,2 ng/mL vs. 49,5±9,2 ng/mL, p7%), siendo significativamente mayores los niveles de ET-1 en este grupo (p7%) and in these patients, ET-1 plasma levels were significantly increased (p<0.01), but not sE-S (p=0.74). These results show that obesity and a poor glycemic control increase the endothelial dysfunction in type 2 diabetes patients.Fil: Velarde, María Susana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Prado, María Mercedes. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Carrizo, Teresita del Rosariio. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Abregu, Adela Victoria. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentin

Amaranth protein improves lipid profile and insulin resistance in a diet-induced obese mice model

"Amaranth has been claimed as functional food, but its function on obesity-related disorder is not fully known. The aim of this study was to analyse the effect of amaranth protein intake on blood lipids profile and insulin resistance in diet-induced obese mice. The effect of soybean protein was also analysed for comparative purposes. C57BL-6 mice were fed for eight weeks with regular or high fat diet. Amaranth or soybean protein isolates (10 mg/kg) were supplied via oral administration. Changes in body weight, adipose tissue, total cholesterol, triglycerides, insulin, a glucose tolerance test, as well as the expression of lipid metabolism-related genes were measured. Our results have shown that amaranth protein induces a decrease in plasma insulin in mice fed with a regular diet, whereas a decrease in triglycerides was observed in mice fed with high fat diet. Furthermore, down-regulation of Tnf-? and Res, suggested the inhibition of inflammation state. The present study demonstrates that amaranth protein, but not soybean protein, improves the obese mice health, and the hormonal modulation (Lep, Fasn, Lpl) could lead to new mechanism of action by which amaranth consumption exerts its beneficial health effect.

Un caso inusual de endocarditis de válvula tricúspide nativa por Candida parapsilosis secundario al uso de catéter de diálisis tunelizado

Candida endocarditis is a severe disease associated with high mortality rates. Candida parapsilosis is frequently identified as the causative pathogen in intravenous drug users and is commonly associated with nosocomial infections, primarily due to its ability to form biofilms on catheters or other foreign bodies. Here, we present a rare case of Candida parapsilosis endocarditis affecting the native tricuspid valve in a 35-year-old male patient with end-stage chronic kidney disease (Stage V), who had a suspected fungal infection related to the left cervical catheter. The patient received treatment with caspofungin and underwent excision of a verrucous tumor on the tricuspid valve. Despite encountering postoperative complications, the patient was discharged on fluconazole treatment and scheduled for follow-up. Candida endocarditis poses a clinical challenge that necessitates a multidisciplinary approach and tailored management due to its infrequent occurrence and higher mortality rate compared to bacterial endocarditis.La endocarditis por Candida es una enfermedad grave asociada con tasas de mortalidad elevadas. Candida parapsilosis se identifica con frecuencia como un patógeno que afecta usuarios de drogas intravenosas y está comúnmente relacionada con infecciones nosocomiales, principalmente debido a su capacidad para formar biopelículas en catéteres u otros cuerpos extraños. Se presenta un caso inusual de endocarditis por Candida parapsilosis que afecta la válvula tricúspide nativa en un paciente masculino de 35 años con enfermedad renal crónica en etapa terminal (Etapa V), quien tenía una sospecha de infección fúngica relacionada con el catéter cervical izquierdo. El paciente recibió tratamiento con caspofungina y se sometió a la extirpación de un tumor verrugoso en la válvula tricúspide. A pesar de enfrentar complicaciones posoperatorias, el paciente fue dado de alta con tratamiento de fluconazol y se programó un seguimiento. La endocarditis por Candida presenta un desafío clínico que requiere un enfoque multidisciplinario y un manejo personalizado debido a su ocurrencia infrecuente y una tasa de mortalidad más alta en comparación con la endocarditis bacteriana

Plataforma de servicios especializada en la orientación financiera de trabajadores independientes urbanos

El presente trabajo de tesis desarrolla la creación e implementación de la plataforma virtual DecideMejor.pe, que brindará a los trabajadores independientes urbanos de Lima las herramientas necesarias para mejorar la administración y toma de decisiones de sus finanzas personales. Así, se fomentará la obtención de una adecuada calidad de vida futura al comparar y conocer mejor los productos financieros actuales a fin de garantizar sus objetivos de crecimiento económico. Este proyecto, nace en un contexto donde la economía de los trabajadores independientes ha mostrado un crecimiento sostenido en los últimos años. Sin embargo, producto de la reciente crisis de incertidumbre de la COVID 19, se experimentó un escenario económico complejo donde ejercer un mejor control y conocimiento financiero personal, se convirtió en una necesidad. La investigación realizada para la creación de la solución, abarca un análisis sobre el perfil de trabajadores independientes, su comportamiento frente al ahorro y productos de inversión, y el impacto positivo y contribución de la solución a los objetivos de desarrollo sostenible. Además, muestra hallazgos relevantes como la necesidad de fuentes de información integradas, confiables, accesibles y de fácil comprensión para la toma de decisiones en la administración de sus recursos económicos. Se determinó un modelo de negocio de generación de leads o potenciales clientes para las entidades financieras o de seguros, a través del cual la plataforma se convierte en un canal para que estos aliados estratégicos, logren captar clientes perfilados, con un interés en particular, sobre los productos y servicios que se ofrecen. Como resultado final se logró diseñar un producto rentable y sostenible enfocado a brindar información sobre productos financieros.This thesis work develops the creation and implementation of the virtual platform DecideMejor.pe, which will provide urban independent workers in Lima with the necessary tools to improve the administration and decision-making of their personal finances. Thus, obtaining an adequate quality of future life will be promoted by comparing and learning more about current financial products in order to guarantee their economic growth objectives. This project was born in a context where the economy of independent workers has shown sustained growth in recent years. However, as a result of the recent COVID 19 uncertainty crisis, a complex economic scenario was experienced where exercising better control and personal financial knowledge became a necessity. The research carried out for the creation of the solution includes an analysis of the profile of independent workers, their behavior towards savings and investment products, and the positive impact and contribution of the solution to the sustainable development objectives. In addition, it shows relevant findings such as the need for integrated, reliable, accessible and easily understood sources of information for decision-making in the administration of its economic resources. A business model to generate leads or potential clients was determined for financial or insurance entities, through which the platform becomes a channel for these strategic allies to attract profiled clients, with a particular interest, on the products and services offered. As a final result, it was possible to design a profitable and sustainable product focused on providing information on financial products