New and Significant Bird Records from Bintan Island, Riau Archipelago, Indonesia in 2018

Pulau Bintan is the largest island in the Riau Archipelago, Indonesia. During two brief visits in 2018, a total of eight species new to the island were recorded, increasing the island’s bird checklist to 189 species. These new records are Grey Heron Ardea cinerea, Intermediate Egret Ardea intermedia, Red-wattled Lapwing Vanellus indicus, Horsfield's Bronze-cuckoo Chalcites basalis, Tiger Shrike Lanius tigrinus, White-headed Munia Lonchura maja, Sooty-headed Bulbul Pycnonotus aurigaster and Javan Myna Acridotheres javanicus. Three of our new records appear to be new for the Riau Archipelago, increasing the avifaunal checklist for the archipelago to 232 species. Following years of development, little primary vegetation remains on Bintan Island, and our failure to detect any woodpeckers by sight or sound during our visits is worrying in terms of the importance of these birds to ecosystem sustainability. Nonetheless, the island retains sizeable area of natural forests, including some swamp forest patches, and our new and significant records suggest its avifaunal diversity is still understudied and underestimated. We call for relevant Indonesian government agencies and the Bintan Resorts, which manage the northern portion of the island for tourism development, to strengthen efforts in biodiversity research and conservation, as well as habitat restoration, so as to attain the development goal of making Bintan a true “eco-island” for international tourism

The variable relationship between arm and hand use: a rationale for using finger magnetometry to complement wrist accelerometry when measuring daily use of the upper extremity.

Wrist-worn accelerometers are becoming more prevalent as a means to assess use of the impaired upper extremity in daily life after stroke. However, wrist accelerometry does not measure joint movements of the hand, which are integral to functional use of the upper extremity. In this study, we used a custom-built, non-obtrusive device called the manumeter to measure both arm use (via wrist accelerometry) and hand use (via finger magnetometry) of a group of unimpaired subjects while they performed twelve motor tasks at three intensities. We also gave the devices to four stroke subjects and asked them to wear them for six hours a day for one month. From the in-lab testing we found that arm use was a strong predictor of hand use for individual tasks, but that the slope of the relationship varied by up to a factor of ~12 depending on the task being performed. Consistent with this, in the daily use data collected from stroke subjects we found a broad spread in the relationship between arm and hand use. These results suggest that analyzing the spread of the relationship between daily hand and arm use will give more insight into upper extremity recovery than wrist accelerometry or finger magnetometry alone, because the spread reflects the nature of the daily tasks performed as well as the amount of upper extremity use

The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA

BACKGROUND Retention of a subset of introns in spliced polyadenylated mRNA is emerging as a frequent, unexplained finding from RNA deep sequencing in mammalian cells. RESULTS Here we analyze intron retention in T lymphocytes by deep sequencing polyadenylated RNA. We show a developmentally regulated RNA-binding protein, hnRNPLL, induces retention of specific introns by sequencing RNA from T cells with an inactivating Hnrpll mutation and from B lymphocytes that physiologically downregulate Hnrpll during their differentiation. In Ptprc mRNA encoding the tyrosine phosphatase CD45, hnRNPLL induces selective retention of introns flanking exons 4 to 6; these correspond to the cassette exons containing hnRNPLL binding sites that are skipped in cells with normal, but not mutant or low, hnRNPLL. We identify similar patterns of hnRNPLL-induced differential intron retention flanking alternative exons in 14 other genes, representing novel elements of the hnRNPLL-induced splicing program in T cells. Retroviral expression of a normally spliced cDNA for one of these targets, Senp2, partially corrects the survival defect of Hnrpll-mutant T cells. We find that integrating a number of computational methods to detect genes with differentially retained introns provides a strategy to enrich for alternatively spliced exons in mammalian RNA-seq data, when complemented by RNA-seq analysis of purified cells with experimentally perturbed RNA-binding proteins. CONCLUSIONS Our findings demonstrate that intron retention in mRNA is induced by specific RNA-binding proteins and suggest a biological significance for this process in marking exons that are poised for alternative splicing.This work has been supported by grants from the National Health and Medical Research Council (Australia), the Wellcome Trust, the National Institutes of Health (USA) and the Biomedical Research Council (BMRC) of the Agency for Science, Technology and Research (A*STAR), Singapore

Anchor View Allocation for Collaborative Free Viewpoint Video Streaming

In free viewpoint video, a viewer can choose at will any camera angle or the so-called "virtual view" to observe a dynamic 3-D scene, enhancing his/her depth perception. The virtual view is synthesized using texture and depth videos of two anchor camera views via depth-image-based rendering (DIBR). We consider, for the first time, collaborative live streaming of a free viewpoint video, where a group of users may interactively pull and cooperatively share streams of different anchor views. There is a cost to access the anchor views from the live source, a cost to "reconfigure" the peer network due to a change in selected anchors during view switching, and a distortion cost due to the distance of the virtual views to the received anchor views at users. We optimize the anchor views allocated to users so as to minimize the overall streaming cost given by the access cost, reconfiguration cost, and view distortion cost. We first show that, if the reconfiguration cost due to view switching is negligible, the view allocation problem can be optimally and efficiently solved in polynomial time using dynamic programming. For the case of non-negligible reconfiguration cost, the problem becomes NP-hard. We thus present a locally optimal and centralized algorithm inspired by Lloyd's algorithm used in non-uniform scalar quantization. We further propose a distributed algorithm with convergence guarantee, where each peer group independently makes merge-and-split decisions with a well-defined fairness criteria. Simulation results show that our algorithms achieve low streaming cost due to its excellent anchor view allocation

Do robotic and non-robotic arm movement training drive motor recovery after stroke by a common neural mechanism? Experimental evidence and a computational model.

Different dose-matched, upper extremity rehabilitation training techniques, including robotic and non-robotic techniques, can result in similar improvement in movement ability after stroke, suggesting they may elicit a common drive for recovery. Here we report experimental results that support the hypothesis of a common drive, and develop a computational model of a putative neural mechanism for the common drive. We compared weekly motor control recovery during robotic and unassisted movement training techniques after chronic stroke (n = 27), as assessed with quantitative measures of strength, speed, and coordination. The results showed that recovery in both groups followed an exponential time course with a time constant of about 4-5 weeks. Despite the greater range and speed of movement practiced by the robot group, motor recovery was very similar between the groups. The premise of the computational model is that improvements in motor control are caused by improvements in the ability to activate spared portions of the damaged corticospinal system, as learned by a biologically plausible search algorithm. Robot-assisted and unassisted training would in theory equally drive this search process

Effects of Psychological Benefits of Greenness on Airlines’ Customer Experiential Satisfaction, Service Fairness, Alternative Attractiveness, and Switching Intention

In the context of climate change, this study uncovers the role of green airlines’ social responsibility in conjunction with the consumers’ switching behavior while considering the effects of latent variables, including green psychology, airline corporate image, green experimental behavior, green service fairness, green alternative attractiveness and switching intention, were examined in the study

Identifying gaps in HIV service delivery across the diagnosis-to-treatment cascade: findings from health facility surveys in six sub-Saharan countries.

INTRODUCTION: Despite the rollout of antiretroviral therapy (ART), challenges remain in ensuring timely access to care and treatment for people living with HIV. As part of a multi-country study to investigate HIV mortality, we conducted health facility surveys within 10 health and demographic surveillance system sites across six countries in Eastern and Southern Africa to investigate clinic-level factors influencing (i) use of HIV testing services, (ii) use of HIV care and treatment and (iii) patient retention on ART. METHODS: Health facilities (n = 156) were sampled within 10 surveillance sites: Nairobi and Kisumu (Kenya), Karonga (Malawi), Agincourt and uMkhanyakude (South Africa), Ifakara and Kisesa (Tanzania), Kyamulibwa and Rakai (Uganda) and Manicaland (Zimbabwe). Structured questionnaires were administered to in-charge staff members of HIV testing, prevention of mother-to-child transmission (PMTCT) and ART units within the facilities. Forty-one indicators influencing uptake and patient retention along the continuum of HIV care were compared across sites using descriptive statistics. RESULTS: The number of facilities surveyed ranged from six in Malawi to 36 in Zimbabwe. Eighty percent were government-run; 73% were lower-level facilities and 17% were district/referral hospitals. Client load varied widely, from less than one up to 65 HIV testing clients per provider per week. Most facilities (>80%) delivered services or interventions that would support patient retention in care such as delivering free services, offering PMTCT within antenatal care, pre-ART monitoring and adherence counselling. Many facilities under-delivered in several areas, however, such as targeted testing for high-risk groups (21%) and mobile testing (36%). There were also intra-site and inter-site differences, including in the delivery of Option B+ (ranging from 6% in Kisumu to 93% in Kyamulibwa), and nurse-led ART initiation (ranging from 50% in Kisesa to 100% in Karonga and Agincourt). Only facilities in Malawi did not require additional lab tests for ART initiation. Stock-outs of HIV test kits and antiretroviral drugs were particularly common in Tanzania. CONCLUSION: We identified a high standard of health facility performance in delivering strategies that may support progression through the continuum of HIV care. HIV testing policy and practice was particularly weak. Inter- and intra-country differences in quality and coverage represent opportunities to improve the delivery of comprehensive services to people living with HIV